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Drug Metabolism Reviews Volume 12, 1981 - Issue 2
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Research Article

Sulindac: Therapeutic Implications of the Prodrug/Pharmacophore Equilibrium

Daniel E. Duggan Merck Institute for Therapeutic Research Merck Sharp & Dohme Research Laboratories West Point, Pennsylvania, 19486
Pages 325-337 | Published online: 22 Sep 2008

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J.T. Archibald. (1984) A Case Report of Suspected Sulindac Poisoning. Canadian Society of Forensic Science Journal 17:2, pages 71-76.
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Articles from other publishers (37)

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Pei Jiang, Yuanjie Ma, Yu Gao, Zhixiong Li, Shan Lian, Zhou Xu, Weixin Jiang, Xiaoting Tian & Chenggang Huang. (2016) Comprehensive Evaluation of the Metabolism of Genipin-1-β- d -gentiobioside in Vitro and in Vivo by Using HPLC-Q-TOF . Journal of Agricultural and Food Chemistry 64:27, pages 5490-5498.
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Jérémy Rocca, Sylvie Manin, Anne Hulin, Abdel Aissat, Wilfried Verbecq‐Morlot, Virginie Prulière‐Escabasse, Adeline Wohlhuter‐Haddad, Ralph Epaud, Pascale Fanen & Agathe Tarze. (2016) New use for an old drug: COX‐independent anti‐inflammatory effects of sulindac in models of cystic fibrosis. British Journal of Pharmacology 173:11, pages 1728-1741.
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Stephanie T. Dance-Barnes, Nancy D. Kock, Joseph E. Moore, Elaine Y. Lin, Libyadda J. Mosley, Ralph B. D'AgostinoJrJr, Thomas P. McCoy, Alan J. Townsend & Mark Steven Miller. (2009) Lung tumor promotion by curcumin. Carcinogenesis 30:6, pages 1016-1023.
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Maria Leuschner, Julia Holtmeier, Hanns Ackermann & Ulrich Leuschner. (2002) The influence of sulindac on patients with primary biliary cirrhosis that responds incompletely to ursodeoxycholic acid. European Journal of Gastroenterology & Hepatology 14:12, pages 1369-1376.
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Zhong-Yue Sun, Emad Botros, Ai-Duen Su, Yu Kim, Enju Wang, Nesrine Z. Baturay & Chul-Hoon Kwon. (2000) Sulfoxide-Containing Aromatic Nitrogen Mustards as Hypoxia-Directed Bioreductive Cytotoxins. Journal of Medicinal Chemistry 43:22, pages 4160-4168.
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Michael P. Hay, William R. Wilson & William A. Denny. (2000) Design, Synthesis and Evaluation of Imidazolylmethyl Carbamate Prodrugs of Alkylating Agents. Tetrahedron 56:4, pages 645-657.
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Giulia Caron, Patrick Gaillard, Pierre‐Alain Carrupt & Bernard Testa. (2004) Lipophilicity Behavior of Model and Medicinal Compounds containing a suilfide, sulfoxide, or sulfone moiety. Helvetica Chimica Acta 80:2, pages 449-462.
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S.C. Lee & A.G. Renwick. (1995) Sulphoxide reduction by rat and rabbit tissues in vitro. Biochemical Pharmacology 49:11, pages 1557-1565.
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William R. Ravis, Charles J. Diskin, Keith D. Campagna, C. Randall Clark & Carl L. McMillian. (2013) Pharmacokinetics and Dialyzability of Sulindac and Metabolites in Patients with End‐Stage Renal Failure. The Journal of Clinical Pharmacology 33:6, pages 527-534.
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DG Waller & CF George. (2012) Prodrugs.. British Journal of Clinical Pharmacology 28:5, pages 497-507.
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David K. Klassen, Robert L. Stout, Patricia S. Spilman & Andrew Whelton. (2013) Sulindac Kinetics and Effects on Renal Function and Prostaglandin Excretion in Renal Insufficiency. The Journal of Clinical Pharmacology 29:11, pages 1037-1042.
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L.-O. Eriksson & H. Boström. (1988) Deactivation of Sulindac-Sulphide by Human Renal Microsomes. Pharmacology & Toxicology 62:4, pages 177-183.
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M. Sato, K. Abe, K. Takeuchi, M. Yasujima, T. Hagino, S. Fang, M. Kohzuki & K. Yoshinaga. 1987. Vasodepressor Hormones in Hypertension: Prostaglandins and Kallikrein-Kinins. Vasodepressor Hormones in Hypertension: Prostaglandins and Kallikrein-Kinins 37 42 .
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William L. Henrich, D. Craig Brater & William B. Campbell. (1986) Renal hemodynamic effects of therapeutic plasma levels of sulindac sulfide during hemorrhage. Kidney International 29:2, pages 484-489.
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D. Craig Brater. (1986) Drug-drug and drug-disease interactions with nonsteroidal anti-inflammatory drugs. The American Journal of Medicine 80:1, pages 62-77.
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Don Kau, Joseph H. Krushinski & David W. Robertson. (2006) Preparation of 14 C‐ and 18 O‐labeled 2‐[2‐methoxy‐4‐(methylsulfinyl)phenyl]‐1H‐imidazo[4,5‐c]‐pyridine hydrochloride (LY175326), a cardiotonic with inotropic and vasodilator activities . Journal of Labelled Compounds and Radiopharmaceuticals 22:10, pages 1045-1060.
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Valentino J. Stella & Kenneth J. Himmelstein. 1985. Directed Drug Delivery. Directed Drug Delivery 247 267 .
Tsuneyoshi Nakamura, Tsuneki Nagasaka & I. Jon Russell. (1982) Effects of Sulindac on in vitro immunologic function and on prostaglandin production by human peripheral blood mononuclear leukocytes. Immunopharmacology 5:2, pages 157-167.
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