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Research Article

The Metabolic Disposition of Etodolac in Rats, Dogs, and Man

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Pages 339-362 | Published online: 22 Sep 2008

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Takako Furukawa, Yoichi Naritomi, Kazuhiro Tetsuka, Fumihiro Nakamori, Hiroyuki Moriguchi, Katsuhiro Yamano, Shigeyuki Terashita, Kenji Tabata & Toshio Teramura. (2014) Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys. Xenobiotica 44:3, pages 205-216.
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K. Tougou, H. Gotou, Y. Ohno & A. Nakamura. (2004) Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man. Xenobiotica 34:5, pages 449-461.
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J. A. Scatina, D. R. Hicks, M. Kraml & M. N. Cayen. (1989) Disposition of a new tetrahydrocarbazole analgesic drug in laboratory animals and man. Xenobiotica 19:9, pages 991-1002.
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M. N. Cayen, R. Gonzalez, E. S. Ferdinandi, E. Greselin, D. R. Hicks, M. Kraml & D. Dvornik. (1986) The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs. Xenobiotica 16:3, pages 251-263.
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E. S. Ferdinandi, S. N. Sehgal, C. A. Demerson, J. Dubuc, J. Zilber, D. Dvornik & M. N. Cayenf. (1986) Disposition and biotransformation of 14C-etodolac in man. Xenobiotica 16:2, pages 153-166.
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Articles from other publishers (46)

Lon V. Kendall, Vanessa L. Oliver & Trinka W. Adamson. 2023. Anesthesia and Analgesia in Laboratory Animals. Anesthesia and Analgesia in Laboratory Animals 139 185 .
Yannan Zhu & You Huang. (2020) Construction of CF 3 -Containing Tetrahydropyrano[3,2- b ]indoles through DMAP-Catalyzed [4+1]/[3+3] Domino Sequential Annulation . Organic Letters 22:17, pages 6750-6755.
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Shayne Gad, Mark Morse & Christopher Kemper. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 567 670 .
Radica M. Stepanovi?-Petrovi?Maja A. Tomi?Sonja M. Vu?kovi?Goran Poznanovi?Nenad D. Ugre?i?Milica ?. Prostran & Bogdan Bo?kovi?. (2011) Pharmacological interaction between oxcarbazepine and two COX inhibitors in a rat model of inflammatory hyperalgesia. Pharmacology Biochemistry and Behavior 97:3, pages 611-618.
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Gia Klauss, Elizabeth A. Giuliano, Cecil P. Moore, Charles M. Stuhr, Stacy L. Martin, Jeff W. Tyler, Kelsie E. Fitzgerald & Debra A. Crawford. (2007) Keratoconjunctivitis sicca associated with administration of etodolac in dogs: 211 cases (1992–2002). Journal of the American Veterinary Medical Association 230:4, pages 541-547.
Crossref
J. L. DAVIS, M. G. PAPICH, A. J. MORTON, J. GAYLE, A. T. BLIKSLAGER & N. B. CAMPBELL. (2007) Pharmacokinetics of etodolac in the horse following oral and intravenous administration. Journal of Veterinary Pharmacology and Therapeutics 30:1, pages 43-48.
Crossref
Sarah Miles. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 5 .
Stephen L. Curry, Steven M. Cogar & James L. Cook. (2005) Nonsteroidal Antiinflammatory Drugs: A Review. Journal of the American Animal Hospital Association 41:5, pages 298-309.
Crossref
Naomi Morita, Hiroyuki Kusuhara, Yoshitane Nozaki, Hitoshi Endou & Yuichi Sugiyama. (2005) FUNCTIONAL INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 2 ( SLC22A7 ) IN THE HEPATIC UPTAKE OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG KETOPROFEN . Drug Metabolism and Disposition 33:8, pages 1151-1157.
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Julia E. Tomlinson, B. Osbone Wilder, Karen M. Young & Anthony T. Blikslager. (2004) Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia. American Journal of Veterinary Research 65:6, pages 761-769.
Crossref
Luc R. Borer, John E. Peel, Wolfgang Seewald, Peter Schawalder & David E. Spreng. (2003) Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. American Journal of Veterinary Research 64:11, pages 1429-1437.
Crossref
David L. Panciera & Spencer A. Johnston. (2002) Results of thyroid function tests and concentrations of plasma proteins in dogs administered etodolac. American Journal of Veterinary Research 63:11, pages 1492-1495.
Crossref
Jay C Albretsen. (2002) Oral medications. Veterinary Clinics of North America: Small Animal Practice 32:2, pages 421-442.
Crossref
Ketan P. Shah, Kavita Gumbhir-Shah & Harry G. Brittain. 2002. 105 147 .
Shive M.S. CHAUHAN, Srinivas A. KANDADAI & Bishwabhusan SAHOO. (2001) Regioselective Biomimetic Oxidation of Etodolac with Iodosylbenzene Catalyzed by Halogenated and Perhalogenated Metalloporphyrins in Dichloromethane.. CHEMICAL & PHARMACEUTICAL BULLETIN 49:10, pages 1375-1376.
Crossref
Ashley E. Fenwick. 2001. 319 329 .
Karol A. Mathews. (2000) Nonsteroidal Anti-Inflammatory Analgesics. Veterinary Clinics of North America: Small Animal Practice 30:4, pages 783-804.
Crossref
Joseph P. Boni, Joan M. Korth-Bradley, Patrick Martin, Donna K. Simcoe, Lyette S. Richards, Robert Rennebohm & Philip D. Walson. (1999) Pharmacokinetics of etodolac in patients with stable juvenile rheumatoid arthritis. Clinical Therapeutics 21:10, pages 1715-1724.
Crossref
Michele E. Reimer, Spencer A. Johnston, Michael S. Leib, Robert B. DuncanJrJr, David C. Reimer, Michele Marini & Kimberly Gimbert. (1999) The Gastroduodenal Effects of Buffered Aspirin, Carprofen, and Etodolac in Healthy Dogs. Journal of Veterinary Internal Medicine 13:5, pages 472-477.
Crossref
Joseph Boni, Joan Korth‐Bradley, Karen McGoldrick, Alan Appel & Stephen Cooper. (2013) Pharmacokinetic and Pharmacodynamic Action of Etodolac in Patients after Oral Surgery. The Journal of Clinical Pharmacology 39:7, pages 729-737.
Crossref
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. Goppelt­Strübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Mes­singer, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst & D. Youssef. 1999. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 403 481 .
Spencer A. Johnston & Steven C. Budsberg. (1997) Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids for The Management of Canine Osteoarthritis. Veterinary Clinics of North America: Small Animal Practice 27:4, pages 841-862.
Crossref
Richard Fruncillo, Steven Troy, Vernon Parker, Michael Mayersohn, David Hicks, Michael Kraml, Michele Battle & Soong Chiang. (1996) Pharmacokinetics of the aldose reductase inhibitor tolrestat: Studies in healthy young and elderly male and female subjects and in subjects with diabetes. Clinical Pharmacology & Therapeutics 59:6, pages 603-612.
Crossref
R. Melarange, C. Gentry, P. R. Blower, C. D. N. Toseland & R. Spangler. (1995) Nabumetone, in contrast to etodolac, lacks gastrointestinal irritancy in the rat: Assessment by the inflammatory marker, haptoglobin, and blood loss. Inflammopharmacology 3:3, pages 259-270.
Crossref
Claudio Giachetti, Alessandro Assandri, Giovanni Zanolo & Emilio Brembilla. (2005) Gas chromatography–mass spectrometry determination of etodolac in human plasma following single epicutaneous administration. Biomedical Chromatography 8:4, pages 180-183.
Crossref
Richard Melarange, Clive Gentry, Michael Durie, Caroline O'Connell & Peter R. Blower. (1994) Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Digestive Diseases and Sciences 39:3, pages 601-608.
Crossref
Dion R. Brocks, Fakhreddin Jamali, Anthony S. Russell & Kenneth J. Skeith. (2013) The Stereoselective Pharmacokinetics of Etodolac in Young and Elderly Subjects, and After Cholecystectomy. The Journal of Clinical Pharmacology 32:11, pages 982-989.
Crossref
Dion R. Brocks & Fakhreddin Jamali. (1991) Enantioselective Pharmacokinetics of Etodolac in the Rat: Tissue Distribution, Tissue Binding, and In Vitro Metabolism. Journal of Pharmaceutical Sciences 80:11, pages 1058-1061.
Crossref
J. A. Scatina, H. B. Kimmel, V. Weinstein, S. M. Troy, S. F. Sisenwine & M. N. Cayen. (2006) Species differences in the pharmacokinetics of recainam, a new anti‐arrhythmic drug. Biopharmaceutics & Drug Disposition 11:5, pages 445-461.
Crossref
J. A. Scattna, D. R. Hicks, M. Kraml & M. N. Cayen. (1990) Metabolic disposition and pharmacokinetics of pelrinone, a new cardiotonic drug, in laboratory animals and man. European Journal of Drug Metabolism and Pharmacokinetics 15:1, pages 37-48.
Crossref
D. C. Brater & K. C. Lasseter. (1989) Profile of etodolac: Pharmacokinetic evaluation in special populations. Clinical Rheumatology 8:S1, pages 25-35.
Crossref
D. Dvornik & D. K. H. Lee. (1989) Theoretical mechanism for the gastrointestinal safety of etodolac: Selective sparing of cytoprotective prostaglandins. Clinical Rheumatology 8:S1, pages 16-24.
Crossref
M. Dey, R. Enever, M. Marino, J. Michelucci, D. Smith, R. Warner & R. Weierstall. (1989) Sustained-release etodolac bioavailability and dose proportionality: correlation between in vivo and in vitro performance. International Journal of Pharmaceutics 49:2, pages 121-128.
Crossref
Leslie G. Humber. (2006) Etodolac: The chemistry, pharmacology, metabolic disposition, and clinical profile of a novel anti‐inflammatory pyranocarboxylic acid. Medicinal Research Reviews 7:1, pages 1-28.
Crossref
David K.H. Lee. (2008) Effect of etodolac on the prostaglandin concentrations in the kidney of the normal rat. Drug Development Research 9:4, pages 305-311.
Crossref
G. A. Balint & V. Varró. (1986) The effect of cigarette smoke on gastroduodenal mucosal endogenous prostacyclin level (Experimental and clinical observations). Agents and Actions 19:3-4, pages 224-232.
Crossref
Gerald W. Gaston, Richard D. Mallow & Judith E. Frank. (2012) Comparison of Etodolac, Aspirin and Placebo for Pain After Oral Surgery. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 6:5, pages 199-205.
Crossref
Ginette Jacob, Marianne Messina, Jacqueline Kennedy, Carol Epstein, Marie Sanda & John Mullane MD. (2013) Minimum Effective Dose of Etodolac for the Treatment of Rheumatoid Arthritis. The Journal of Clinical Pharmacology 26:3, pages 195-202.
Crossref
Charles C. Marsh, Arthur A. Schuna & Walter R. Sundstrom. (2012) A Review of Selected Investigational Nonsteroidal Antiinflammatory Drugs of the 1980s. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 6:1, pages 10-25.
Crossref
N.N. Singh, F. Jamali, F.M. Pasutto, R.T. Coutts & A.S. Russell. (1986) Stereoselective gas chromatographic analysis of etodolac enantiomers in human plasma and urine. Journal of Chromatography B: Biomedical Sciences and Applications 382, pages 331-337.
Crossref
Mitchell N. Cayen. (1985) Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man. Pharmacology & Therapeutics 29:2, pages 157-204.
Crossref
Gerald W. Gaston, Richard D. Mallow & Judith E. Frank. (1984) The efficacy of etodolac for patients with pain following oral surgery. Journal of Oral and Maxillofacial Surgery 42:6, pages 362-366.
Crossref
M. Kraml, L. Cosyns, D. R. Hicks, J. Simon, J. F. Mullane & D. Dvornik. (2006) Bioavailability studies with etodolac in dogs and man. Biopharmaceutics & Drug Disposition 5:1, pages 63-74.
Crossref
Charles E. Hutton. (1983) The effectiveness of 100 and 200 mg etodolac (Ultradol), aspirin, and placebo in patients with pain following oral surgery. Oral Surgery, Oral Medicine, Oral Pathology 56:6, pages 575-580.
Crossref
M. Spain, L. Cosyns & M. Kraml. (1983) Sensitive High-Performance Liquid Chromatographie Method for the Determination of Etodolac in Serum. Journal of Pharmaceutical Sciences 72:3, pages 275-277.
Crossref
O. William LeverJr.Jr., Kwen-Jen Chang & John D. McDermed. 1983. 51 60 .

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