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Drug Metabolism Reviews Volume 13, 1982 - Issue 5
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Research Article

Differentiation of Genetic Versus Epigenetic Mechanisms of Toxicity and Its Application to Risk Assessment

W. T. Stott Dow Chemical, Midland, Michigan, 48640, USA
&
P. G. Watanabe Dow Chemical, Midland, Michigan, 48640, USA
Pages 853-873 | Published online: 22 Sep 2008

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Lora E. Rikans. (1989) Influence of Aging on Chemically Induced Hepato-Toxicity: Role of Age-Related Changes in Metabolism. Drug Metabolism Reviews 20:1, pages 87-110.
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Wolfgang Dekant, Spyridon Vamvakas & M. W. Anders. (1989) Bioactivation of Nephrotoxic Haloalkenes by Glutathione Conjugation: Formation of Toxic and Mutagenic Intermediates by Cysteine Conjugate β-Lyase. Drug Metabolism Reviews 20:1, pages 43-83.
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D. J. Doolittle, G. Muller & H. E. Scribner. (1987) Relationship between hepatotoxicity and induction of replicative DNA synthesis following single or multiple doses of carbon tetrachloride. Journal of Toxicology and Environmental Health 22:1, pages 63-78.
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ClarkS. Olson & DavidJ. Schaeffer. (1986) Application of the “filter model” to a risk assessment for vinyl chloride. Journal of Toxicology and Environmental Health 17:1, pages 1-22.
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Charles Hurst & William Smith. 2000. Chemical Warfare Agents. Chemical Warfare Agents.
Takeshi Morita & Makoto Hayashi. (1998) 1,4-Dioxane is not mutagenic in five in vitro assays and mouse peripheral blood micronucleus assay, but is in mouse liver micronucleus assay. Environmental and Molecular Mutagenesis 32:3, pages 269-280.
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. (1994) Chapter 5: Polychlorinated biphenyls. Regulatory Toxicology and Pharmacology 20:1, pages S187-S307.
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. (1994) Chapter 1: Introduction and Methods. Regulatory Toxicology and Pharmacology 20:1, pages S1-S68.
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Wolfgang Dekant & Spyridon Vamvakas. 1992. 297 337 .
Dietrich Henschler & Wolfgang Dekant. (1990) Nephrocarcinogenic xenobiotics. Toxicology Letters 53:1-2, pages 105-110.
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K.T. Kitchin & J.L. Brown. (1990) Is 1,4-dioxane a genotoxic carcinogen?. Cancer Letters 53:1, pages 67-71.
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Leung Hon-Wing & Dennis J. Paustenbach. (1990) Cancer risk assessment for dioxane based upon a physiologically-based pharmacokinetic approach. Toxicology Letters 51:2, pages 147-162.
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Kirk T. Kitchin, Janice L. Brown & William Lijinsky. (1989) Biochemical studies of six nitrogen-containing heterocycles in rat tissues. Biochemical Pharmacology 38:16, pages 2733-2738.
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W.T. Stott. (1988) Chemically induced proliferation of peroxisomes: Implications for risk assessment. Regulatory Toxicology and Pharmacology 8:2, pages 125-159.
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. (1986) Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens.. Environmental Health Perspectives 67, pages 201-282.
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Eric H. Von Hofe, Paul C. Billings, Charles Heidelberger & Joseph R. Landolph. (1986) In vitro genotoxicity studies using complex hydrophobic mixtures: Efficient delivery of a petroleum sample to cultured C3H/10T1/2 cells via lipid vesicle incorporation. Environmental Mutagenesis 8:4, pages 589-609.
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Kathryn M. Milam & James L. Byard. (1985) Acetaminophen metabolism, cytotoxicity, and genotoxicity in rat primary hepatocyte cultures. Toxicology and Applied Pharmacology 79:2, pages 342-347.
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G. M. Williams & J. H. Weisburger. 1985. Progress in Drug Research. Progress in Drug Research 155 213 .
S. Ved Brat & G.M. Williams. (1984) Nitrilotriacetic acid does not induce sister-chromatid exchanges in hamster or human cells. Food and Chemical Toxicology 22:3, pages 211-215.
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Barbara L. Harper & Debra L. Morris. (2005) Implications of multiple mechanisms of carcinogenesis for short‐term testing. Teratogenesis, Carcinogenesis, and Mutagenesis 4:6, pages 483-503.
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Keizo Furuya, Hideki Mori & Gary M. Williams. (1983) An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide. Toxicology and Applied Pharmacology 70:1, pages 49-56.
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G. M. Williams & J. H. Weisburger. (1983) Carcinogen Risk Assessment. Science 221:4605, pages 6-6.
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