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Drug Metabolism Reviews Volume 13, 1982 - Issue 6
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Research Article

Pharmacokinetic Considerations in Toxicity Testing

David J. Jollow Department of Pharmacology, Medical University of South Carolina Charleston, South Carolina, 29425
,
Stanley Roberts Department of Pharmacology, Medical University of South Carolina Charleston, South Carolina, 29425
,
Veronica Price Department of Pharmacology, Medical University of South Carolina Charleston, South Carolina, 29425
,
Stephen Longacre Department of Pharmacology, Medical University of South Carolina Charleston, South Carolina, 29425
&
Carole Smith Department of Pharmacology, Medical University of South Carolina Charleston, South Carolina, 29425
Pages 983-1007 | Published online: 22 Sep 2008

Citations (13)

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Read on this site (3)

Veronica F. Price & D. J. Jollow. (1984) Role of UDPGA flux in acetaminophen clearance and hepatotoxicity. Xenobiotica 14:7, pages 553-559.
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Gerhard Levy, Raymond E. Galinsky & Jiunn Huei Lin. (1982) Pharmacokinetic Consequences and Toxicologic Implications of Endogenous Cosubstrate Depletion. Drug Metabolism Reviews 13:6, pages 1009-1020.
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James R. Gillette. (1982) The Problem of Chemically Reactive Metabolites. Drug Metabolism Reviews 13:6, pages 941-961.
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Articles from other publishers (10)

Shayne Gad & Samantha Gad-McDonald. 2015. Biomaterials, Medical Devices, and Combination Products. Biomaterials, Medical Devices, and Combination Products 469 502 .
D. Gwyn Morgan, Alan S. Kelvin, Lewis B. Kinter, Colin J. Fish, William D. Kerns & Gerald Rhodes. (2016) The Application of Toxicokinetic Data to Dosage Selection in Toxicology Studies. Toxicologic Pathology 22:2, pages 112-123.
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Alastair Monro. (1992) What is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents?. Toxicology and Applied Pharmacology 112:2, pages 171-181.
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A.M. Monro. (1990) Interspecies comparisons in toxicology: The utility and futility of plasma concentrations of the test substance. Regulatory Toxicology and Pharmacology 12:2, pages 137-160.
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Stephen M. Spaethe & David J. Jollow. (1989) Effect of cobalt protoporphyrin on hepatic drug-metabolizing enzymes. Biochemical Pharmacology 38:12, pages 2027-2038.
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Veronica F. Price & David J. Jollow. (1988) Mechanism of decreased acetaminophen glucuronidation in the fasted rat. Biochemical Pharmacology 37:6, pages 1067-1075.
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Veronica F. Price, Marion G. Miller & David J. Jollow. (1987) Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat. Biochemical Pharmacology 36:4, pages 427-433.
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Marion G. Miller, Veronica F. Price & David J. Jollow. (1986) Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity. Biochemical Pharmacology 35:5, pages 817-825.
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Veronica F. Price & David J. Jollow. (1986) Strain differences in susceptibility of normal and diabetic rats to acetaminophen hepatotoxicity. Biochemical Pharmacology 35:4, pages 687-695.
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Rehan H. Naqvi, Satya B. Mitra & Marjorie C. Lindberg. (1984) Effect of dose on the pharmacokinetics of levonorgestrel in the rat during the rapid elimination phase following subcutaneous administration. Contraception 30:6, pages 599-605.
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