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Drug Metabolism Reviews Volume 13, 1982 - Issue 6
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Research Article

Pharmacokinetic Consequences and Toxicologic Implications of Endogenous Cosubstrate Depletion

Gerhard Levy Department of Pharmaceutics, School of Pharmacy-State University of New York at Buffalo Amherst, New York, 14260
,
Raymond E. Galinsky Department of Pharmaceutics, School of Pharmacy-State University of New York at Buffalo Amherst, New York, 14260
&
Jiunn Huei Lin Department of Pharmaceutics, School of Pharmacy-State University of New York at Buffalo Amherst, New York, 14260
Pages 1009-1020 | Published online: 22 Sep 2008

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Read on this site (5)

David E. C. Cole & Jovan Evrovski. (2000) The Clinical Chemistry of Inorganic Sulfate. Critical Reviews in Clinical Laboratory Sciences 37:4, pages 299-344.
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James Gillette, Elizabeth K. Weisburger, Herman Kraybill & Morris Kelsey. (1985) Strategies for Determining the Mechanisms of Toxicity. Journal of Toxicology: Clinical Toxicology 23:1, pages 1-78.
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Raymond E. Galinsky, D Pharm, Gerhard Levy & D Pharm. (1984) Evaluation Of Activated Charcoal-Sodium Sulfate Combination For Inhibition Of Acetaminophen Absorption And Repletion Of Inorganic Sulfate. Journal of Toxicology: Clinical Toxicology 22:1, pages 21-30.
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Marilyn E. Morris & Gerhard Levy. (1983) Absorption of Sulfate from Orally Administered Magnesium Sulfate in Man. Journal of Toxicology: Clinical Toxicology 20:2, pages 107-114.
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James R. Gillette. (1982) The Problem of Chemically Reactive Metabolites. Drug Metabolism Reviews 13:6, pages 941-961.
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Articles from other publishers (20)

Jingyun Li, Angela L. Chiew, Geoffrey K. Isbister & Stephen B. Duffull. (2020) Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose. British Journal of Clinical Pharmacology 87:5, pages 2392-2396.
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Ho-Leung Fung & William J. Jusko. (2015) Perspectives on the history and scientific contributions of Gerhard Levy. Journal of Pharmacokinetics and Pharmacodynamics 42:5, pages 429-446.
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Hartley C. Atkinson, Ioana Stanescu, Isam I. Salem, Amanda L. Potts & Brian J. Anderson. (2014) Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. European Journal of Clinical Pharmacology 71:2, pages 151-158.
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Alexander V. LyubimovBennett Ma & Michael L. Schrag. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 29 .
Pavan Vajjah, Geoffrey K. Isbister & Stephen B. Duffull. 2012. Computational Toxicology. Computational Toxicology 289 312 .
C K Gelotte, J F Auiler, J M Lynch, A R Temple & J T Slattery. (2007) Disposition of Acetaminophen at 4, 6, and 8 g/day for 3 Days in Healthy Young Adults. Clinical Pharmacology & Therapeutics 81:6, pages 840-848.
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Ruediger Kock, Heike Schneider, Bert Delvoux & Helmut Greiling. (1997) The Determination of Inorganic Sulphate in Serum and Synovial Fluid by High Performance Ion Chromatography. Clinical Chemistry and Laboratory Medicine 35:9.
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J. H. K. Yeung, L. C. M. Chiu & V. E. C. Ooi. (1995) Effect of polysaccharide peptide (PSP) on in vivo sulphation and glucuronidation of paracetamol in the rat. European Journal of Drug Metabolism and Pharmacokinetics 20:4, pages 287-292.
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D. J. Back & M. L’E. Orme. 1994. Steroid Contraceptives and Women’s Response. Steroid Contraceptives and Women’s Response 103 123 .
Shahrzad Bakhtian, Robert E. Kimura & Raymond E. Galinsky. (1993) Age-related changes in homeostasis on inorganic sulfate in male F-344 rats. Mechanisms of Ageing and Development 66:3, pages 257-267.
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N. R. Campbell & B. Baylis. (1992) Renal impairment associated with an acute paracetamol overdose in the absence of hepatotoxicity.. Postgraduate Medical Journal 68:796, pages 116-118.
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R. A. Willson, J. Hart & T. Hall. (2009) The Concentration and Temporal Relationships of Acetaminophen‐Induced Changes in Intracellular and Extracellular Total Glutathione in Freshly Isolated Hepatocytes from Untreated and 3‐Methylcholanthrene Pretreated Sprague‐Dawley and Fischer Rats*. Pharmacology & Toxicology 69:3, pages 205-212.
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T.J. Maziasz, J. Liu, C. Madhu & C.D. Klaassen. (1991) The differential effects of hepatotoxicants on the sulfation pathway in rats. Toxicology and Applied Pharmacology 110:3, pages 365-373.
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H.M. Blackledge, J. O'Farrell, N.A. Minton & A.E.M. McLean. (2016) The Effect of Therapeutic Doses of Paracetamol on Sulphur Metabolism in Man. Human & Experimental Toxicology 10:3, pages 159-165.
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GR Loewen, RJ Herman, SG Ross & RK Verbeeck. (2012) Effect of dose on the glucuronidation and sulphation kinetics of diflunisal in man: single dose studies.. British Journal of Clinical Pharmacology 26:1, pages 31-39.
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D. J. BACK & S. M. ROGERS. (2007) Review: first‐pass metabolism by the gastrointestinal mucosa. Alimentary Pharmacology & Therapeutics 1:5, pages 339-357.
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SM Rogers, DJ Back, PJ Stevenson, SF Grimmer & ML Orme. (1987) Paracetamol interaction with oral contraceptive steroids: increased plasma concentrations of ethinyloestradiol.. British Journal of Clinical Pharmacology 23:6, pages 721-725.
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Marilyn E. Morris, Francis M. Gengo, William R. Kinkel, Daniel A. Castellani & Gerhard Levy. (1986) Effect of Acetaminophen on Inorganic Sulfate Concentrations in Human Cerebrospinal Fluid. Journal of Pharmaceutical Sciences 75:7, pages 722-723.
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S. Hendrix-Treacy, S. M. Wallace, K. W. Hindmarsh, G. M. Wyant & A. Danilkewich. (1986) The effect of acetaminophen administration on its disposition and body stores of sulphate. European Journal of Clinical Pharmacology 30:3, pages 273-278.
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G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1986. Introduction to Drug Metabolism. Introduction to Drug Metabolism 39 81 .

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