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Research Article

Metabolic Activation of Aflatoxin B1: Patterns of DNA Adduct Formation, Removal, and Excretion in Relation to Carcinogenesis

John M. Essigmann Laboratory of Toxicology Department of Nutrition and Food Science, Massachusetts Institute of Technology Cambridge, Massachusetts, 02139
,
Robert G. Croy Sidney Farber Cancer Institute Harvard Medical School Boston, Massachusetts, 02144
,
Richard A. Bennett Milton S. Hershey Medical Center Hershey, Pennsylvania, 17033
&
Gerald N. Wogan Massachusetts Institute of Technology
Pages 581-602 | Published online: 22 Sep 2008

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Jean-Baptiste Aholia Adépo, Pierre Manda, Jean Verdier Ngbé, Aïssata Diakité, Béatrice Tigori Sangaré & Sébastien Djédjé Dano. (2019) Study of aflatoxicosis reduction: effect of Alchornea cordifolia on biomarkers in an aflatoxin B1 exposed rats. Drug and Chemical Toxicology 42:3, pages 243-251.
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Nina Bilandžić, Ivana Varenina, Božica Solomun Kolanović, Đurđica Božić Luburić, Ines Varga, Blaženka Želježić, Luka Cvetnić, Miroslav Benić, Sanin Tanković & Željko Cvetnić. (2017) Occurrence of aflatoxin M1 in raw cow, goat and sheep milk during spring and autumn in Croatia during 2016. Toxin Reviews 36:4, pages 290-296.
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Magda Carvajal, Jaime Berumen & Mariano Guardado-Estrada. (2012) The presence of aflatoxin B1-FAPY adduct and human papilloma virus in cervical smears from cancer patients in Mexico. Food Additives & Contaminants: Part A 29:2, pages 258-268.
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P. Galtier. (1999) Biotransformation and Fate of Mycotoxins. Journal of Toxicology: Toxin Reviews 18:3-4, pages 295-312.
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S. K. Nigam, S. K. Ghosh & Ravi Malaviya. (1994) Aflatoxin, Its Metabolism and Carcinogenesis - A Historical Review. Journal of Toxicology: Toxin Reviews 13:2, pages 179-203.
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Shehla Hashim, V. S. Aboobaker, R. Madhubala, R. K. Bhattacharya & A. R. Rao. (1994) Modulatory effects of essential oils from spices on the formation of DNA adduct by aflatoxin B1 in vitro . Nutrition and Cancer 21:2, pages 169-175.
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Catherine Billaud. (1991) Effects of harmane on growth and in vivo metabolism of aflatoxin B1 in male and female rats. Food Additives & Contaminants 8:6, pages 713-722.
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RobertW. Teel. (1991) Effects of capsaicin on rat liver S9‐mediated metabolism and DNA binding of aflatoxin. Nutrition and Cancer 15:1, pages 27-32.
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P. D. Lotlikar. (1989) Metabolic Basis for Susceptibility and Resistance to Aflatoxin B1 Hepatocarcinogenesis in Rodents. Journal of Toxicology: Toxin Reviews 8:1-2, pages 97-109.
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HowardS. Ramsdell & DavidL. Eaton. (1988) Modification of aflatoxin B1 biotransformation in vitro and DNA binding in vivo by dietary broccoli in rats. Journal of Toxicology and Environmental Health 25:3, pages 269-284.
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GregoryA. Reed. (1988) Oxidation of environmental carcinogens by prostaglandin H synthase. Environmental Carcinogenesis Reviews 6:2, pages 223-259.
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C. J. Holeski, D. L. Eaton, D. H. Monroe & G. M. Bellamy. (1987) Effects of phenobarbital on the biliary excretion of aflatoxin P 1-glucuronide and aflatoxin B1-S-glutathione in the rat. Xenobiotica 17:2, pages 139-153.
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Herman A. J. Schut & Andre Castonguay. (1984) Metabolism of Carcinogenic Amino Derivatives in Various Species and DNA Alkylation by Their Metabolites. Drug Metabolism Reviews 15:4, pages 753-839.
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E. J. Ariëns. (1984) Domestication of Chemistry by Design of Safer Chemicals: Structure-Activity Relationships. Drug Metabolism Reviews 15:3, pages 425-504.
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