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Drug Metabolism Reviews Volume 13, 1982 - Issue 2
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Research Article

Selectivity of Alkylation and Aralkylation of Nucleic Acid Components

A. Dipple Chemical Carcinogenesis Program, NCI-Frederick Cancer Research Facility, Frederick, Maryland, 21701
,
R. C. Moschel Chemical Carcinogenesis Program, NCI-Frederick Cancer Research Facility, Frederick, Maryland, 21701
&
W. R. Hudgins Chemical Carcinogenesis Program, NCI-Frederick Cancer Research Facility, Frederick, Maryland, 21701
Pages 249-268 | Published online: 22 Sep 2008

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Yanhe Huang & Francis Johnson. (2002) REGIOSELECTIVE 1-ALKYLATION OF 2′-DEOXYGUANOSINE. Nucleosides, Nucleotides & Nucleic Acids 21:6-7, pages 435-447.
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Ki-Young Moon & Yeong Shik Kim. (2000) A One-Pot Preparation of 1-Benzyl-2′-deoxyinosine from ionized 2′-Deoxyinosine. Nucleosides, Nucleotides & Nucleic Acids 19:7, pages 1135-1143.
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E. J. Ariëns. (1984) Domestication of Chemistry by Design of Safer Chemicals: Structure-Activity Relationships. Drug Metabolism Reviews 15:3, pages 425-504.
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Brian Coles. (1984) Effects of Modifying Structure on Electrophilic Reactions with Biological Nucleophiles. Drug Metabolism Reviews 15:7, pages 1307-1334.
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A. Luch & W.M. Baird. 2010. Comprehensive Toxicology. Comprehensive Toxicology 85 123 .
Ki-Young Moon, Young Jong Lee & Yeong Shik Kim. (2003) Upregulation of Cellular NF-.KAPPA.B Activity by Alkylating Carcinogens in Human Epidermal Keratinocytes. Biological and Pharmaceutical Bulletin 26:8, pages 1195-1197.
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Jerry M. Parks, George P. Ford & Christopher J. Cramer. (2001) Quantum Chemical Characterization of the Reactions of Guanine with the Phenylnitrenium Ion. The Journal of Organic Chemistry 66:26, pages 8997-9004.
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Ki-Young Moon & Yeong Shik Kim. (2000) Synthesis and characterization of oligonucleotides containing site-specific bulky N2-aralkylated guanines and N6-aralkylated adenines. Archives of Pharmacal Research 23:2, pages 139-146.
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Philip C Burcham. (1999) Internal hazards: baseline DNA damage by endogenous products of normal metabolism. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 443:1-2, pages 11-36.
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Thomas Barlow & Anthony Dipple. (1998) Aralkylation of Guanosine with Para-Substituted Styrene Oxides. Chemical Research in Toxicology 11:1, pages 44-53.
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George P. Ford. (1997) Semiempirical molecular orbital theory in carcinogenesis research. Journal of Molecular Structure: THEOCHEM 401:3, pages 253-266.
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Rosalie K. Elespuru. (1996) Future approaches to genetic toxicology risk assessment. Mutation Research/Reviews in Genetic Toxicology 365:1-3, pages 191-204.
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Lynnette R. Ferguson & William A. Denny. (1995) Anticancer drugs: an underestimated risk or an underutilised resource in mutagenesis?. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 331:1, pages 1-26.
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Rajivinder S. Brar & Arthur W. Bull. (1993) Effect of alkyl sulfides on diazomethane-induced methylation of DNA in vitro. Cancer Letters 73:2-3, pages 121-125.
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Mieczysław Zieliński & Marianna Kańska. 1993. Hydroxyl, Ether and Peroxide Groups (1993). Hydroxyl, Ether and Peroxide Groups (1993) 473 585 .
Anthony Dipple, C. Anita & H. Bigger. (1991) Mechanism of action of food-associated polycyclic aromatic hydrocarbon carcinogens. Mutation Research/Genetic Toxicology 259:3-4, pages 263-276.
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Nrusingha C. Mishra & Barry Gold. (2006) Synthesis of 13 C‐ and 14 C‐labeled ellagic acid . Journal of Labelled Compounds and Radiopharmaceuticals 28:8, pages 927-941.
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George P. Ford & Christopher T. Smith. (2004) An MNDO molecular orbital study of the reactions of protonated oxirane derivatives (XCHCH 2 OH + , X = CN, Cl, CH 3 , Ph) with simple nucleophiles. Implications for regioselectivity in the reactions of electrophiles with nucleic acid bases . Journal of Computational Chemistry 10:4, pages 568-592.
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Anders Brunmark & Enrique Cadenas. (1989) Redox and addition chemistry of quinoid compounds and its biological implications. Free Radical Biology and Medicine 7:4, pages 435-477.
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George P. Ford & Christopher T. Smith. (1987) An MNDO molecular orbital study of the reactions of protonated oxirane with guanine. International Journal of Quantum Chemistry 32:S14, pages 57-64.
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George P. Ford & Christopher T. Smith. (2009) An MNDO molecular orbital study of the reactions of protonated oxirane with simple nucleophiles. International Journal of Quantum Chemistry 30:S13, pages 107-119.
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