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Drug Metabolism Reviews Volume 14, 1983 - Issue 1
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Research Article

The Use of Theoretical Pharmacokinetic Concepts in Studies of the Mechanisms of Formation of Chemically Reactive Metabolites in Vitro and in Vivo

James R. Gillette Laboratory of Chemical Pharmacology National Heart, Lung, and Blood Institute National Institutes of Health Bethesda, Maryland, 20205
Pages 9-33 | Published online: 22 Sep 2008

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James R. Gillette. (1995) Keynote Address: Man, Mice, Microsomes, Metabolites, and Mathematics 40 Years after the Revolution. Drug Metabolism Reviews 27:1-2, pages 1-44.
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F. Peter Guengerich, Daniel C. Liebler & Donald L. Reed. (1985) Enzymatic activation of chemicals to toxic metabolites. CRC Critical Reviews in Toxicology 14:3, pages 259-307.
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Ellen M. Faed. (1984) Properties of Acyl Glucuronides: Implications for Studies of the Pharmacokinetics and Metabolism of Acidic Drugs. Drug Metabolism Reviews 15:5-6, pages 1213-1249.
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Articles from other publishers (8)

Desmond O. Agwunobi, Mengxue Li, Ningmei Wang, Guomin Chang, Xiaojing Zhang, Xiaomin Xue, Zhijun Yu, Hui Wang & Jingze Liu. (2022) Proteomic analysis suggests that monoterpenes in lemongrass disrupt Ca 2+ homeostasis in Haemaphysalis longicornis leading to mitochondrial depolarization and cytotoxicity . PROTEOMICS 22:13-14, pages 2100156.
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Desmond O. Agwunobi, Meng Zhang, Xiaojing Zhang, Tongxuan Wang, Zhijun Yu & Jingze Liu. (2021) Transcriptome profile of Haemaphysalis longicornis (Acari: Ixodidae) exposed to Cymbopogon citratus essential oil and citronellal suggest a cytotoxic mode of action involving mitochondrial Ca2+ overload and depolarization. Pesticide Biochemistry and Physiology 179, pages 104971.
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Kirstin Thelen & Jennifer B Dressman. (2009) Cytochrome P450-mediated metabolism in the human gut wall. Journal of Pharmacy and Pharmacology 61:5, pages 541-558.
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Bernard Testa & Stefanie D. Krämer. (2006) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 3:10, pages 1053-1101.
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Donald J. AbrahamBernard Testa & William Soine. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 431 498 .
Jack A. Hinson & Poh-Gek Forkert. (1995) Phase II enzymes and bioactivation. Canadian Journal of Physiology and Pharmacology 73:10, pages 1407-1413.
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J.L. Maggs, N.R. Kitteringham, P.S. Grabowski & B.K. Park. (1986) Drug-protein conjugates—X. Biochemical Pharmacology 35:3, pages 505-513.
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Kenji Shiromizu & Donald R. Mattison. (2005) Murine oocyte destruction following intraovarian treatment with 3‐methylcholanthrene or 7,12‐dimethylbenz(a)anthracene: Protection by alpha‐naphthoflavone. Teratogenesis, Carcinogenesis, and Mutagenesis 5:6, pages 463-472.
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