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Research Article

The Effect of Intercellular Distribution of Drug-Metabolizing Enzymes on the Kinetics of Stable Metabolite Formation and Elimination by Liver: First-Pass Effects

Pages 61-76 | Published online: 22 Sep 2008

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Qi Joy Yang & K. Sandy Pang. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 83 101 .
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K. S. Pang & M. Chiba. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 101 187 .
A. N. Lutsevich & V. F. Kirichuk. (1993) Pharmacokinetic modeling of the elimination of drugs by the liver. II. Influence of the localization and activity of metabolizing enzymes and the rate of blood flow in the liver on the clearance of drugs (review). Pharmaceutical Chemistry Journal 26:11-12, pages 813-819.
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Magdy H. Abdelhameed, Tien-Mien Chen & Win L. Chiou. (1993) Intrahepatic Distribution of Hydrochlorothiazide and Quinidine in Rats: Implications in Pharmacokinetics. Journal of Pharmaceutical Sciences 82:10, pages 992-996.
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Berend Mets, Rosemary Hickman, Rosemary Allin, Jean van Dyk & Zoe Lotz. (1993) Effect of hypoxia on the hepatic metabolism of lidocaine in the isolated perfused pig liver. Hepatology 17:4, pages 668-676.
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Hye J. Lee & Win L. Chiou. (1990) Marked Heterogeneity in the Intrahepatic Distribution of Quinidine in Rats: Implications in Pharmacokinetics. Journal of Pharmaceutical Sciences 79:9, pages 778-781.
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Xin Xu & K. Sandy Pang. (1989) Hepatic modeling of metabolite kinetics in sequential and parallel pathways: Salicylamide and gentisamide metabolism in perfused rat liver. Journal of Pharmacokinetics and Biopharmaceutics 17:6, pages 645-671.
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Dirk K. F. Meijer. 2011. Comprehensive Physiology. Comprehensive Physiology 717 758 .
K. Sandy Pang, Wai-Fong Lee, Wendy F. Cherry, Vincent Yuen, Josephine Accaputo, Shirin Fayz, Andreas J. Schwab & Carl A. Goresky. (1988) Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: Characterization by the multiple indicator dilution technique. Journal of Pharmacokinetics and Biopharmaceutics 16:6, pages 595-632.
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Barbara L. Harper & Marvin S. Legator. (1987) Pyridine prevents the clastogenicity of benzene but not of benzo[a]pyrene or cyclophosphamide. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 179:1, pages 23-31.
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K. Sandy Pang. (1985) A review of metabolite kinetics. Journal of Pharmacokinetics and Biopharmaceutics 13:6, pages 633-662.
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Toshihiko Fujii, Hisashi Miyazaki & Masahisa Hashimoto. (1984) Autoradiographic and biochemical studies of drug distribution in the liver III. [14C] Aminotriazole. European Journal of Drug Metabolism and Pharmacokinetics 9:3, pages 257-265.
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Win L. Chiou. (1983) Mean Hepatic Transit Time in the Determination of Mean Absorption Time. Journal of Pharmaceutical Sciences 72:11, pages 1365-1368.
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