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Research Article

Cutaneous Pharmacokinetics: 10 Steps to Percutaneous Absorption

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Pages 169-205 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (27)

Jordan L. Bormann & Howard I. Maibach. (2020) Effects of anatomical location on in vivo percutaneous penetration in man. Cutaneous and Ocular Toxicology 39:3, pages 213-222.
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Becky S. Li, John Havens Cary & Howard I. Maibach. (2019) Should we instruct patients to rub topical agents into skin? The evidence. Journal of Dermatological Treatment 30:4, pages 328-332.
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Kit Frederiksen, Richard H. Guy & Karsten Petersson. (2016) The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs. Expert Opinion on Drug Delivery 13:3, pages 349-360.
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Tina Bhutani, John Koo & Howard I. Maibach. (2012) Efficacy of clobetasol spray: Factors beyond patient compliance. Journal of Dermatological Treatment 23:1, pages 11-15.
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Yue Zheng, Aline Vieille-Petit, Stephanie Chodoutaud & Howard I. Maibach. (2011) Dislodgeable stratum corneum exfoliation: role in percutaneous penetration?. Cutaneous and Ocular Toxicology 30:3, pages 198-204.
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E. Dika, A. Tosti, M. Goldovsky, R. Wester & H. I. Maibach. (2006) Percutaneous Absorption of Crotamiton in Man Following Single and Multiple Dosing. Cutaneous and Ocular Toxicology 25:3, pages 211-216.
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Somnath Singh, Kaidi Zhao & Jagdish Singh. (2003) In Vivo Percutaneous Absorption, Skin Barrier Perturbation, and Irritation from JP-8 Jet Fuel Components. Drug and Chemical Toxicology 26:2, pages 135-146.
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Somnath Singh, Kaidi Zhao & Jagdish Singh. (2002) IN VITRO PERMEABILITY AND BINDING OF HYDROCARBONS IN PIG EAR AND HUMAN ABDOMINAL SKIN. Drug and Chemical Toxicology 25:1, pages 83-92.
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Ronald C. Wester & Howard I. Maibach. (2001) In vivo methods for percutaneous absorption measurements. Journal of Toxicology: Cutaneous and Ocular Toxicology 20:4, pages 411-422.
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Ronald C. Wester & Howard I. Maibach. (2001) Skin contamination and absorption of chemicals from water and soil. Journal of Toxicology: Cutaneous and Ocular Toxicology 20:2-3, pages 319-333.
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Ronald C. Wester & Howard I. Maibach. (2000) Understanding Percutaneous Absorption for Occupational Health and Safety. International Journal of Occupational and Environmental Health 6:2, pages 86-92.
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Yedidia Bentur, Oren Shoshani, Arek Tabak, Alon Binnun, Yitzhak Ramon, Yehuda Ulman, Yosef Berger, Tal Nachlieli & Yitzhak J. Peled. (1998) Prolonged Elimination Half-Life of Phenol After Dermal Exposure. Journal of Toxicology: Clinical Toxicology 36:7, pages 707-711.
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J.G.M. VanRooij, J.H.C. De Roos, M.M. Bodelier‐Bade & F.J. Jongeneelen. (1993) Absorption of polycyclic aromatic hydrocarbons through human skin: Differences between anatomical sites and individuals. Journal of Toxicology and Environmental Health 38:4, pages 355-368.
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RonaldC. Wester, HowardI. Maibach, Lena Sedik, Joseph Melendres, ChengL. Liao & Stephen DiZio. (1992) Percutaneous absorption of [14C]chlordane from soil. Journal of Toxicology and Environmental Health 35:4, pages 269-277.
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RichardP. Moody, ClaireA. Franklin, Leonard Ritter & HowardI. Maibach. (1990) Dermal absorption of the phenoxy herbicides 2,4‐D, 2,4‐D amine, 2,4‐D isooctyl, and 2,4,5‐T in rabbits, rats, rhesus monkeys, and humans: A cross‐species comparison. Journal of Toxicology and Environmental Health 29:3, pages 237-245.
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GloriaA. Skowronski, RitaM. Turkall & MohamedS. Abdel‐Rahman. (1989) Effects of soil on percutaneous absorption of toluene in male rats. Journal of Toxicology and Environmental Health 26:3, pages 373-384.
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RichardP. Moody, FrankM. Benoit, Dieter Riedel & Leonard Ritter. (1989) Dermal absorption of the insect repellent deet (N,N‐diethyl‐m‐toluamide) in rats and monkeys: Effect of anatomical site and multiple exposure. Journal of Toxicology and Environmental Health 26:2, pages 137-147.
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G. Nicolau & A. Yacobi. (1989) Transdermal Absorption and Skin Metabolism of Viprostol, A Synthetic Prostaglandin E2 Analogue. Drug Metabolism Reviews 21:3, pages 401-425.
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EdwardW. Sidon, RichardP. Moody & ClaireA. Franklin. (1988) Percutaneous absorption of cis‐and trans‐permethrin in rhesus monkeys and rats: Anatomic site and interspecies variation. Journal of Toxicology and Environmental Health 23:2, pages 207-216.
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RichardP. Moody, Dieter Riedel, Leonard Ritter & ClaireA. Franklin. (1987) The effect of DEET (N,N‐diethyl‐m‐toluamide) on dermal persistence and absorption of the insecticide fenitrothion in rats and monkeys. Journal of Toxicology and Environmental Health 22:4, pages 471-479.
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RonaldC. Wester, Mohammad Mobayen & HowardI. Maibach. (1987) In vivo and in vitro absorption and binding to powdered stratum corneum as methods to evaluate skin absorption of environmental chemical contaminants from ground and surface water. Journal of Toxicology and Environmental Health 21:3, pages 367-374.
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C. Richard Cothern & FrankJ. Letkiewicz. (1986) Techniques for the assessment of carcinogenic risk due to drinking water contaminants. Critical Reviews in Environmental Control 16:4, pages 357-399.
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RonaldC. Wester & HowardI. Maibach. (1985) In vivo percutaneous absorption and decontamination of pesticides in humans. Journal of Toxicology and Environmental Health 16:1, pages 25-37.
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RonaldC. Wester, HowardI. Maibach, DanielA. W. Bucks & MichaelB. Aufrere. (1984) In vivo percutaneous absorption of paraquat from hand, leg, and forearm of humans. Journal of Toxicology and Environmental Health 14:5-6, pages 759-762.
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R. C. Wester, D. A. W. Bucks, H. I. Maibach & J. Anderson. (1983) Polychlorinated biphenyls (PCBs): Dermal absorption, systemic elimination, and dermal wash efficiency. Journal of Toxicology and Environmental Health 12:4-6, pages 511-519.
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Esther Patrick & Howard I. Maibach. 1995. Textbook of Contact Dermatitis. Textbook of Contact Dermatitis 703 747 .
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I. Choonara. (1994) Percutaneous drug absorption and administration. Archives of Disease in Childhood - Fetal and Neonatal Edition 71:2, pages F73-F74.
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