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Drug Metabolism Reviews Volume 14, 1983 - Issue 2
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Research Article

Drug Metabolism in the Elderly: Confounding of Age, Smoking, and Ethanol Effects

E. M. Sellers Clinical Pharmacology Program, Clinical Institute Addiction Research Foundation, Ontario, Canada; Departments of Pharmacology and Medicine, Institute of Biomedical Engineering University of Toronto Toronto, Ontario, Canada
,
R. C. Frecker Clinical Pharmacology Program, Clinical Institute Addiction Research Foundation, Ontario, Canada; Departments of Pharmacology and Medicine, Institute of Biomedical Engineering University of Toronto Toronto, Ontario, Canada
&
M. K. Romach Clinical Pharmacology Program, Clinical Institute Addiction Research Foundation, Ontario, Canada; Departments of Pharmacology and Medicine, Institute of Biomedical Engineering University of Toronto Toronto, Ontario, Canada
Pages 225-250 | Published online: 22 Sep 2008

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Lisa L. von Moltke, David J. Greenblatt, Myroslava K. Romach & Edward M. Sellers. (2001) Cognitive toxicity of drugs used in the elderly. Dialogues in Clinical Neuroscience 3:3, pages 181-190.
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K. Taeger. 1991. Der geriatrische Patient in der Anaesthesie. Der geriatrische Patient in der Anaesthesie 23 30 .
Timothy A. Roehrs & Thomas Roth. (1989) Drugs, Sleep Disorders, and Aging. Clinics in Geriatric Medicine 5:2, pages 395-404.
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T. Colombo, M.G. Donelli, R. Urso, S. Dallarda, I. Bartosek & A. Guaitani. (1989) Doxorubicin toxicity and pharmacokinetics in old and young rats. Experimental Gerontology 24:2, pages 159-171.
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HOWARD D. CAPPELL. (2010) The Addiction Research Foundation of Ontario. British Journal of Addiction 82:10, pages 1081-1089.
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J Posner, M Danhof, MW Teunissen, DD Breimer & PD Whiteman. (2012) The disposition of antipyrine and its metabolites in young and elderly healthy volunteers.. British Journal of Clinical Pharmacology 24:1, pages 51-55.
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P.M. Edelbroek, F.G. Zitman, E.A.M.Knoppert-van der Klein, P.M. Van Putten^ & F.A. De Wolff. (1987) Therapeutic drug monitoring of amitriptyline: Impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women. Clinica Chimica Acta 165:2-3, pages 177-187.
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D. Trenk, H. Althen, E. Jähnchen, T. Meinertz & S. Øie. (1987) Factors responsible for interindividual differences in the dose requirement of phenprocoumon. European Journal of Clinical Pharmacology 33:1, pages 49-54.
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M. Beerahee, M. R. Wilkins, D. B. Jack, D. G. Beevers & M. J. Kendall. (1987) Twelve hour (trough) plasma nifedipine concentrations during chronic treatment with nifedipine retard. European Journal of Clinical Pharmacology 32:4, pages 347-349.
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Frank Pucino, Carol L. Beck, Randall L. Seifert, Gordon L. Strommen, Peggy A. Sheldon & Inger L. Silbergleit. (2012) Pharmacogeriatrics. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 5:6, pages 314-326.
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Jeff Ray GibsonJrJr, Max Kebert Mendenhall & Neil Jeff Axel. (1985) Geriatric Anesthesia: Minimizing the Risk. Clinics in Geriatric Medicine 1:2, pages 313-321.
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David B. Jack. (2008) FACTORS CONTRIBUTING TO VARIABILITY IN DRUG PHARMACOKINETICS. III. METABOLISM. Journal of Clinical Pharmacy and Therapeutics 10:1, pages 25-43.
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JACK E. HENNINGFIELD. 1984. 131 210 .

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