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Research Article

Dose-Dependent Metabolism, Therapeutic Effect, and Toxicity of Anticancer Drugs in Man

Pages 1145-1163 | Published online: 22 Sep 2008

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Tonika Bohnert & Liang‐Shang Gan. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 91 176 .
Toshiyuki Sakaeda, Motohiro Yamamori, Akiko Kuwahara & Kohshi Nishiguchi. (2009) Pharmacokinetics and pharmacogenomics in esophageal cancer chemoradiotherapy. Advanced Drug Delivery Reviews 61:5, pages 388-401.
Crossref
Jaya Chilakapati, Midhun C. Korrapati, Kartik Shankar, Ronald A. Hill, Alan Warbritton, John R. Latendresse & Harihara M. Mehendale. (2007) Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital. Toxicology and Applied Pharmacology 219:1, pages 72-84.
Crossref
R. L. Capizzi & J. C. White. 1992. Acute Leukemias. Acute Leukemias 266 274 .
R. L. Capizzi & K. Agrawal. 1992. Biochemical Pharmacology of Blood and Bloodforming Organs. Biochemical Pharmacology of Blood and Bloodforming Organs 523 564 .
Pierluigi Benedetti Panici, Stefano Greggi, Giovanni Scambia, Guglielmo Ragusa, Gabriela Baiocchi, Francesco Battaglia, Ferdinando Coronetta & Salvatore Mancuso. (1991) High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma: A preliminary report. Gynecologic Oncology 41:3, pages 212-216.
Crossref
Robert L. Capizzi, J. Courtland White & Daniel J. Fernandes. (1991) Antimetabolites. Bailli?re's Clinical Haematology 4:1, pages 15-45.
Crossref
Gurpreet S. Ahluwalia, Jean L. Grem, Zhang Hao & David A. Cooney. (1990) Metabolism and action of amino acid analog anti-cancer agents. Pharmacology & Therapeutics 46:2, pages 243-271.
Crossref
Hsiu‐Ying Yu, Yu‐Zen Shen, Yuichi Sugiyama & Manabu Hanano. (2007) Dose‐Dependent Pharmacokinetics of Valproate in Guinea Pigs of Different Ages. Epilepsia 28:6, pages 680-687.
Crossref
Robert L. Capizzi, Bayard L. Powell, M. Robert Cooper, James P. Rathmell, J. Courtland White, Hyman B. Muss, Frederick Richards II, Don V. Jackson, John J. Stuart, Douglas R. White, Patricia J. Zekan, Julia M. Cruz & Charles L. Spurr. (2009) DOSE-RELATED PHARMACOLOGIC EFFECTS OF HIGH DOSE ARA-C AND ITS USE IN COMBINATION WITH ASPARAGINASE FOR THE TREATMENT OF PATIENTS WITH ACUTE NON-LYHPHOCYTIC LEUKEMIA*. Scandinavian Journal of Haematology 36:S44, pages 17-39.
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