Citations (83)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (6)
Dominique Pessayre, Bernard Fromenty, Alain Berson, Marie-Anne Robin, Philippe Lettéron, Richard Moreau & Abdellah Mansouri. (2012) Central role of mitochondria in drug-induced liver injury. Drug Metabolism Reviews 44:1, pages 34-87.
Read now
Read now
T. W. Schultz, R. E. Carlson, M. T. D. Cronin, J. L. M. Hermens, R. Johnson, P. J. O’Brien, D. W. Roberts, A. Siraki, K. B. Wallace & G. D. Veith. (2006) A conceptual framework for predicting the toxicity of reactive chemicals: modeling soft electrophilicity. SAR and QSAR in Environmental Research 17:4, pages 413-428.
Read now
Read now
Urs A. Boelsterli. (1993) Specific Targets of Covalent Drug-Protein Interactions in Hepatocytes and Their Toxicological Significance in Drug-Induced Liver Injury. Drug Metabolism Reviews 25:4, pages 395-451.
Read now
Read now
Ronald T. H. van Welie, Rob G. J. M. van Dijck, Nico P. E. Vermeulen & Nico J. van Sittert. (1992) Mercapturic Acids, Protein Adducts, and DNA Adducts as Biomarkers of Electrophilic Chemicals. Critical Reviews in Toxicology 22:5-6, pages 271-306.
Read now
Read now
Brian Coles, Brian Ketterer & Jack A. Hinson. (1990) The Role of Glutathione and Glutathione Transferases in Chemical Cardnogenesi. Critical Reviews in Biochemistry and Molecular Biology 25:1, pages 47-70.
Read now
Read now
B. Ketterer. (1986) Detoxication reactions of glutathione and glutathione transferases. Xenobiotica 16:10-11, pages 957-973.
Read now
Read now
Articles from other publishers (77)
Priyanka Sekar, Ricardo P. Martinho, Auke G. Talma, Hubert Gojzewski, Alexander Stücker, Bernhard Schwaiger, Jacob Podschun & Anke Blume. (2023) Horizons in Coupling of Sulfur-Bearing Silanes to Hydrothermally Treated Lignin toward Sustainable Development. ACS Sustainable Chemistry & Engineering 11:48, pages 16882-16892.
Crossref
Crossref
Namrashee V. Mehta & Mariam S. Degani. (2023) The expanding repertoire of covalent warheads for drug discovery. Drug Discovery Today 28:12, pages 103799.
Crossref
Crossref
Xin Wang, Guangyun Ran, Yufen Liao, Bowen Gong, Chutian Wu, Rong Tan, Ying Liu, Shiyu Zhang, Ying Peng, Weiwei Li & Jiang Zheng. (2023) Formation of RNA adducts resulting from metabolic activation of spice ingredient safrole mediated by P450 enzymes and sulfotransferases. Food and Chemical Toxicology 174, pages 113688.
Crossref
Crossref
Joerg Herrmann, Gagan Sahni, Andrea Gallardo, Aferdita Spahillari, Matthew Galsky, Thomas Eschenhagen, Wendy Schaffer, Tomas G. Neilan, Ghosh Ak, Teodora Donisan, Dinu Valentin Balanescu, Cezar Iliescu, Keith Stewart & Carolyn Larsen. 2023. Cardio-Oncology Practice Manual : a Companion to Braunwald 's Heart Disease. Cardio-Oncology Practice Manual : a Companion to Braunwald 's Heart Disease
451
506
.
Paola R. Campodónico, Jazmín Alarcón-Espósito & Belén Olivares. (2022) Kinetics and Reaction Mechanism of Biothiols Involved in SNAr Reactions: An Experimental Study. Frontiers in Chemistry 10.
Crossref
Crossref
Birgitte Lindeman, Ylva Johansson, Mathilda Andreassen, Trine Husøy, Hubert Dirven, Tim Hofer, Helle K. Knutsen, Ida H. Caspersen, Kristine Vejrup, Ragnhild E. Paulsen, Jan Alexander, Anna Forsby & Oddvar Myhre. (2021) Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps. Reproductive Toxicology 101, pages 93-114.
Crossref
Crossref
Ji-Yoon Lee, Sang Kyum Kim, Kiho Lee & Soo Jin Oh. 2021. Advanced Imaging and Bio Techniques for Convergence Science. Advanced Imaging and Bio Techniques for Convergence Science
533
550
.
Xiaojing Yang, Yukun Feng, Zhengyu Zhang, Hui Wang, Weiwei Li, Dan Ohtan Wang, Ying Peng & Jiang Zheng. (2020)
In Vitro
and
In Vivo
Evidence for RNA Adduction Resulting from Metabolic Activation of Methyleugenol
. Journal of Agricultural and Food Chemistry 68:51, pages 15134-15141.
Crossref
Crossref
Holly Robertson, Albena T. Dinkova-Kostova & John D. Hayes. (2020) NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. Cancers 12:12, pages 3609.
Crossref
Crossref
Virbala Sharma & Deepak Pant. (2018) Structural basis for expanding the application of bioligand in metal bioremediation: A review. Bioresource Technology 252, pages 188-197.
Crossref
Crossref
Yukun Feng, Saide Wang, Hui Wang, Ying Peng & Jiang Zheng. (2018) Urinary Methyleugenol-deoxyadenosine Adduct as a Potential Biomarker of Methyleugenol Exposure in Rats. Journal of Agricultural and Food Chemistry 66:5, pages 1258-1263.
Crossref
Crossref
Harshad Devarbhavi, Herbert L. Bonkovsky, Mark Russo & Naga Chalasani. 2018. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology
844
890.e17
.
Ye Tian & Jiang Zheng. 2017.
241
272
.
Philip G. Penketh, Krishnamurthy Shyam, Raymond P. Baumann, Rui Zhu, Kimiko Ishiguro, Alan C. Sartorelli & Elena S. Ratner. (2016) When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments. Analytical Biochemistry 508, pages 34-37.
Crossref
Crossref
J. Chan, T. Oshiro, S. Thomas, A. Higa, S. Black, A. Todorovic, F. Elbarbry & J. P. Harrelson. (2016) Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole. Drug Metabolism and Disposition 44:4, pages 534-543.
Crossref
Crossref
Krishnamurthy Shyam, Philip G. Penketh, Raymond P. Baumann, Rick A. Finch, Rui Zhu, Yong-Lian Zhu & Alan C. Sartorelli. (2015) Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility. Journal of Medicinal Chemistry 58:9, pages 3639-3671.
Crossref
Crossref
Philip G. Penketh, Eric Patridge, Krishnamurthy Shyam, Raymond P. Baumann, Rui Zhu, Kimiko Ishiguro & Alan C. Sartorelli. (2014)
Influence of Glutathione and Glutathione
S
-transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine
. Chemical Research in Toxicology 27:8, pages 1440-1449.
Crossref
Crossref
Philip G. Penketh, Krishnamurthy Shyam, Rui Zhu, Raymond P. Baumann, Kimiko Ishiguro & Alan C. Sartorelli. (2014) Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromustine, KS119, and KS119W. Chemical Research in Toxicology 27:5, pages 818-833.
Crossref
Crossref
Richard M. LoPachin & Terrence Gavin. (2012) Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry. Environmental Health Perspectives 120:12, pages 1650-1657.
Crossref
Crossref
Ji-Yoon Lee, Sang Yoon Lee, Soo Jin Oh, Ki Ho Lee, Young Suk Jung & Sang Kyum Kim. (2012) Assessment of drug–drug interactions caused by metabolism-dependent cytochrome P450 inhibition. Chemico-Biological Interactions 198:1-3, pages 49-56.
Crossref
Crossref
Amy A. Rand & Scott A. Mabury. (2012) Assessing the structure–activity relationships of fluorotelomer unsaturated acids and aldehydes with glutathione. Cell Biology and Toxicology 28:2, pages 115-124.
Crossref
Crossref
Richard M. LoPachin, Terrence Gavin, Anthony DeCaprio & David S. Barber. (2011) Application of the Hard and Soft, Acids and Bases (HSAB) Theory to Toxicant–Target Interactions. Chemical Research in Toxicology 25:2, pages 239-251.
Crossref
Crossref
Xinsheng Gu & Jose E. Manautou. (2012) Molecular mechanisms underlying chemical liver injury. Expert Reviews in Molecular Medicine 14.
Crossref
Crossref
Herbert L. Bonkovsky, Dean P. Jones, Mark W. Russo & Steven I. Shedlofsky. 2012. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology
417
461
.
Kye Sook Lee, Soo Jin Oh, Hwan Mook Kim, Ki Ho Lee & Sang Kyum Kim. (2011) Assessment of reactive metabolites in drug-induced liver injury. Archives of Pharmacal Research 34:11, pages 1879-1886.
Crossref
Crossref
Francisco J. Schopfer, Chiara Cipollina & Bruce A. Freeman. (2011) Formation and Signaling Actions of Electrophilic Lipids. Chemical Reviews 111:10, pages 5997-6021.
Crossref
Crossref
Johannes A. H. Schwöbel, Yana K. Koleva, Steven J. Enoch, Fania Bajot, Mark Hewitt, Judith C. Madden, David W. Roberts, Terry W. Schultz & Mark T. D. Cronin. (2011) Measurement and Estimation of Electrophilic Reactivity for Predictive Toxicology. Chemical Reviews 111:4, pages 2562-2596.
Crossref
Crossref
Richard M. LoPachin, Terrence Gavin, Dennis R. Petersen & David S. Barber. (2009) Molecular Mechanisms of 4-Hydroxy-2-nonenal and Acrolein Toxicity: Nucleophilic Targets and Adduct Formation. Chemical Research in Toxicology 22:9, pages 1499-1508.
Crossref
Crossref
Bernard Testa & Stefanie D. Krämer. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:5, pages 591-684.
Crossref
Crossref
Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
Crossref
Crossref
Richard M. LoPachin, David S. Barber & Terrence Gavin. (2008) Molecular Mechanisms of the Conjugated α,β-Unsaturated Carbonyl Derivatives: Relevance to Neurotoxicity and Neurodegenerative Diseases. Toxicological Sciences 104:2, pages 235-249.
Crossref
Crossref
Marijke A.E. Mol, Roland M. van den Berg & Henk P. Benschop. (2008) Proteomic assessment of sulfur mustard-induced protein adducts and other protein modifications in human epidermal keratinocytes. Toxicology and Applied Pharmacology 230:1, pages 97-108.
Crossref
Crossref
Josh T. Pearson, Jan L. Wahlstrom, Leslie J. Dickmann, Santosh Kumar, James R. Halpert, Larry C. Wienkers, Robert S. Foti & Dan A. Rock. (2007) Differential Time-Dependent Inactivation of P450 3A4 and P450 3A5 by Raloxifene: A Key Role for C239 in Quenching Reactive Intermediates. Chemical Research in Toxicology 20:12, pages 1778-1786.
Crossref
Crossref
T. Wayne Schultz, Jason W. Yarbrough, Robert S. Hunter & Aynur O. Aptula. (2007) Verification of the Structural Alerts for Michael Acceptors. Chemical Research in Toxicology 20:9, pages 1359-1363.
Crossref
Crossref
E. M. Gagan, M. W. Hull, T. W. Schultz, G. Pöch & D. A. Dawson. (2007) Time Dependence in Mixture Toxicity with Soft Electrophiles: 1. Combined Effects of Selected SN2- and SNAr-Reactive Agents with a Nonpolar Narcotic. Archives of Environmental Contamination and Toxicology 52:3, pages 283-293.
Crossref
Crossref
Richard M. LoPachin, David S. Barber, Brian C. Geohagen, Terrence Gavin, Deke He & Soma Das. (2007) Structure-Toxicity Analysis of Type-2 Alkenes: In Vitro Neurotoxicity. Toxicological Sciences 95:1, pages 136-146.
Crossref
Crossref
Douglas A. Dawson, Gerald Pöch & T. Wayne Schultz. (2006) Chemical mixture toxicity testing with Vibrio fischeri: Combined effects of binary mixtures for ten soft electrophiles. Ecotoxicology and Environmental Safety 65:2, pages 171-180.
Crossref
Crossref
Aynur O. Aptula, Grace Patlewicz, David W. Roberts & T.W. Schultz. (2006) Non-enzymatic glutathione reactivity and in vitro toxicity: A non-animal approach to skin sensitization. Toxicology in Vitro 20:2, pages 239-247.
Crossref
Crossref
Herbert L. Bonkovsky, Dean P. Jones, Douglas R. LaBrecque & Steven I. Shedlofsky. 2006. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology
503
550
.
Michael W. Lamé, A. Daniel Jones, Dennis W. Wilson & H. J. Segall. (2005) Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells. PROTEOMICS 5:17, pages 4398-4413.
Crossref
Crossref
Margaret A. Isbell, Dexter Morin, Bridget Boland, Alan Buckpitt, Michelle Salemi & Jack Presley. (2005) Identification of proteins adducted by reactive naphthalene metabolitesin vitro. PROTEOMICS 5:16, pages 4197-4204.
Crossref
Crossref
Richard M. LoPachin & Anthony P. DeCaprio. (2005) Protein Adduct Formation as a Molecular Mechanism in Neurotoxicity. Toxicological Sciences 86:2, pages 214-225.
Crossref
Crossref
Scott R. Baerson, Adela Sánchez-Moreiras, Nuria Pedrol-Bonjoch, Margot Schulz, Isabelle A. Kagan, Ameeta K. Agarwal, Manuel J. Reigosa & Stephen O. Duke. (2005) Detoxification and Transcriptome Response in Arabidopsis Seedlings Exposed to the Allelochemical Benzoxazolin-2(3H)-one. Journal of Biological Chemistry 280:23, pages 21867-21881.
Crossref
Crossref
T. W. Schultz, J. W. Yarbrough & M. Woldemeskel. (2005) Toxicity to T etrahymena and abiotic thiol reactivity of aromatic isothiocyanates. Cell Biology and Toxicology 21:3-4, pages 181-189.
Crossref
Crossref
Michael W. Lamé, A. Daniel Jones, Dennis W. Wilson, Sheryl K. Dunston & H.J. Segall. (2000) Protein Targets of Monocrotaline Pyrrole in Pulmonary Artery Endothelial Cells. Journal of Biological Chemistry 275:37, pages 29091-29099.
Crossref
Crossref
Dominique Pessayre, Delphine Haouzi, Daniel Fau, Marie Anne Robin, Abdellah Mansouri & Alain Berson. (1999) Withdrawal of life support, altruistic suicide, fratricidal killing and euthanasia by lymphocytes: different forms of drug-induced hepatic apoptosis. Journal of Hepatology 31:4, pages 760-770.
Crossref
Crossref
Maudy CMJ Stroombergen & Rosemary H Waring. (2016) Determination of glutathione S-transferase μ and τ polymorphisms in neurological disease. Human & Experimental Toxicology 18:3, pages 141-145.
Crossref
Crossref
John Tor-Agbidye, Valerie S Palmer, Peter S Spencer, A.Morrie Craig, Linda L Blythe & Mohammad I Sabri. (1999) Sodium cyanate alters glutathione homeostasis in rodent brain: relationship to neurodegenerative diseases in protein-deficient malnourished populations in Africa. Brain Research 820:1-2, pages 12-19.
Crossref
Crossref
David J. Boocock, James L. Maggs, Ian N.H. White & B. Kevin Park. (1999) α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro. Carcinogenesis 20:1, pages 153-160.
Crossref
Crossref
Chi-Rei Yang, Yen-Chuan Ou, Jehn-Hwa Kuo, Yu-Lin Kao, Chen-Li Chen, Sheau-Yun Yean, Yu-Ye Horng & Chung-Shi Yang. (1997) Intracellular glutathione content of urothelial cancer in correlation to chemotherapy response. Cancer Letters 119:2, pages 157-162.
Crossref
Crossref
Judy L Bolton, Sherri B Turnipseed & John A Thompson. (1997) Influence of quinone methide reactivity on the alkylation of thiol and amino groups in proteins: studies utilizing amino acid and peptide models. Chemico-Biological Interactions 107:3, pages 185-200.
Crossref
Crossref
Julian Coleman, Mechteld Blake-Kalff & Emyr Davies. (1997) Detoxification of xenobiotics by plants: chemical modification and vacuolar compartmentation. Trends in Plant Science 2:4, pages 144-151.
Crossref
Crossref
Mark A. Lewis, Darla Graff Yoerg, Judy L. Bolton & John A. Thompson. (1996)
Alkylation of 2‘-Deoxynucleosides and DNA by Quinone Methides Derived from 2,6-Di-
tert
-butyl-4-methylphenol
. Chemical Research in Toxicology 9:8, pages 1368-1374.
Crossref
Crossref
Philip G. Penketh, Krishnamurthy Shyam & Alan C. Sartorelli. 1996. Drug Resistance. Drug Resistance
65
81
.
Margaret R. Davis & Thomas A. Baillie. (2005)
Studies on the formation of reactive intermediates from the antineoplastic agent
N
,
N
′Bis(2‐chloroethyl)‐
N
‐nitrosourea (BCNU)
in vitro
and
in Vivo
. Characterization of novel glutathione adducts by ionspray tandem mass spectrometry
. Journal of Mass Spectrometry 30:1, pages 57-68.
Crossref
Crossref
Young-Joon Surh & James A. Miller. (1994) Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons. Chemico-Biological Interactions 92:1-3, pages 351-362.
Crossref
Crossref
Brian Ketterer & Lucia G. Christodoulides. 1994.
37
69
.
Glen R. Shaw & Des W. Connell. 1994. Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology
1
62
.
Charles N. Falany, James Wheeler, Lori Coward, Dawn Keehan, Josie L. Falany & Stephen Barnes. (2006) Bioactivation of 7‐hydroxymethyl‐12‐ methyibenz[a]anthracene by rat liver bile acid sulfotransferase I. Journal of Biochemical Toxicology 7:4, pages 241-248.
Crossref
Crossref
Laurie D. DeLeve & Neil Kaplowitz. (1991) Glutathione metabolism and its role in hepatotoxicity. Pharmacology & Therapeutics 52:3, pages 287-305.
Crossref
Crossref
Jan N. M. Commandeur, Peter J. Boogaard, Gerard J. Mulder & Nico P. E. Vermeulen. (1991) Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene. Archives of Toxicology 65:5, pages 373-380.
Crossref
Crossref
Patrick J. Hayden, Yun Yang, Anthony J. I. Ward, Deanne M. Dulik, Denis J. McCann & James L. Stevens. (2002) Formation of difluorothionoacetyl-protein adducts by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine metabolites: nucleophilic catalysis of stable lysyl adduct formation by histidine and tyrosine. Biochemistry 30:24, pages 5935-5943.
Crossref
Crossref
E.Dinant Kroese, Marco J. Zeilmaker, Georges R. Mohn & John H.N. Meerman. (1990) Preventive action of thioethers towards in vitro DNA binding and mutagenesis in E. coli K12 by alkylating agents. Mutation Research Letters 245:2, pages 67-74.
Crossref
Crossref
Kevin L. Stark, Craig Harris & Mont R. Juchau. (1989) Influence of electrophilic character and glutathione depletion on chemical dysmorphogenesis in cultured rat embryos. Biochemical Pharmacology 38:16, pages 2685-2692.
Crossref
Crossref
N. P. E. Vermeulen, J. de Jong, E. J. C. van Bergen & R. T. H. van Welie. (1989) N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies?. Archives of Toxicology 63:3, pages 173-184.
Crossref
Crossref
Margie L. Clapper & Kenneth D. Tew. 1989. Drug Resistance in Cancer Therapy. Drug Resistance in Cancer Therapy
125
150
.
Brian Ketterer. (1988) Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 202:2, pages 343-361.
Crossref
Crossref
Fred A. Reitman, Howard G. Shertzer & Marc L. Berger. (1988) Toxicity of methylating agents in isolated hepatocytes. Biochemical Pharmacology 37:16, pages 3183-3188.
Crossref
Crossref
Craig Harris, Kevin L. Stark & Mont R. Juchau. (1988) Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro. Teratology 37:6, pages 577-590.
Crossref
Crossref
D. Pessayre & D. Larrey. (1988) 8 Acute and chronic drug-induced hepatitis. Baillière's Clinical Gastroenterology 2:2, pages 385-422.
Crossref
Crossref
Marilee J. Wick, Ibrahim Bin Jantan & Patrick E. Hanna. (1988) Irreversible inhibition of rat hepatic transacetylase activity by N-Arylhydroxamic acids. Biochemical Pharmacology 37:7, pages 1225-1231.
Crossref
Crossref
Kenneth D. Tew. 1988.
265
274
.
Christopher A. Mullin, Kamal A. Rashid & Ralph O. Mumma. (1987) Mutagenic potency of some conjugated nitroaromatic compounds and its relationship to structure. Mutation Research/Genetic Toxicology 188:4, pages 267-274.
Crossref
Crossref
Jean Geneve, Claude Degott, Philippe Letteron, Marina Tinel, Veronique Descatoire, Dominique Larrey, Gilles Amouyal & Dominique Pessayre. (1987) Metabolic activation of the tricyclic antidepressant amineptine—II. Biochemical Pharmacology 36:3, pages 331-337.
Crossref
Crossref
M. Wiessler. (1986) DNA adducts by N-nitroso compounds. Journal of Cancer Research and Clinical Oncology 112:2, pages 81-84.
Crossref
Crossref
Timothy W. Gant, Mary d'Arcy Doherty, Duro Odowole, Keith D. Sales & Gerald M. Cohen. (1986) Semiquinone anion radicals formed by the reaction of quinones with glutathione or amino acids. FEBS Letters 201:2, pages 296-300.
Crossref
Crossref
Brian Ketterer, David J. Meyer, Brian Coles, John B. Taylor & Sally Pemble. 1986. Antimutagenesis and Anticarcinogenesis Mechanisms. Antimutagenesis and Anticarcinogenesis Mechanisms
103
126
.