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Research Article

Interspecies Pharmacokinetic Scaling and the Evolutionary-Comparative Paradigm

Pages 1071-1121 | Published online: 22 Sep 2008

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Iftekhar Mahmood. (2018) Misconceptions and issues regarding allometric scaling during the drug development process. Expert Opinion on Drug Metabolism & Toxicology 14:8, pages 843-854.
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Iftekhar Mahmood. (2015) Prediction of drug clearance in children: a review of different methodologies. Expert Opinion on Drug Metabolism & Toxicology 11:4, pages 573-587.
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Sherri Smith, Jennifer Hoyt, Nigel Whitebread, Joseph Manna, Marisa Peluso, Kerrie Faia, Veronica Campbell, Martin Tremblay, Somarajan Nair, Michael Grogan, Alfredo Castro, Matthew Campbell, Jeanne Ferguson, Brendan Arsenault, Jylle Nevejans, Bennett Carter, John Lee, Joi Dunbar, Karen McGovern, Margaret Read, Julian Adams, Alexander Constan, Gordon Loewen, Jens Sydor, Vito Palombella & John Soglia. (2013) The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway. Xenobiotica 43:10, pages 875-885.
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Kotaro Ogawa, Motohiro Kato, Takao Houjo & Masaki Ishigai. (2013) A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. Xenobiotica 43:5, pages 468-478.
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Iftekhar Mahmood & Kosalaram Goteti. (2012) Prediction of drug concentration-time data in humans from animals: a comparison of three methods. Xenobiotica 42:8, pages 756-765.
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Hannah M Jones, Maurice Dickins, Kuresh Youdim, James R Gosset, Neil J Attkins, Tanya L Hay, Ian K Gurrell, Y Raj Logan, Peter J Bungay, Barry C Jones & Iain B Gardner. (2012) Application of PBPK modelling in drug discovery and development at Pfizer. Xenobiotica 42:1, pages 94-106.
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Rong Deng, Suhasini Iyer, Frank-Peter Theil, Deborah L. Mortensen, Paul J. Fielder & Saileta Prabhu. (2011) Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data. mAbs 3:1, pages 61-66.
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H. Wong, J.Z. Chen, B. Chou, J.S. Halladay, J.R. Kenny, H. La, J.C. Marsters$suffix/text()$suffix/text(), E. Plise, P.J. Rudewicz, K. Robarge, Y. Shin, S. Wong, C. Zhang & S.C. Khojasteh. (2009) Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Xenobiotica 39:11, pages 850-861.
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Stefan S De Buck & Claire E Mackie. (2007) Physiologically based approaches towards the prediction of pharmacokinetics: in vitro–in vivo extrapolation. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 865-878.
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Marcella Martignoni, Geny M M Groothuis & Ruben de Kanter. (2006) Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 875-894.
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LorenzR. Rhomberg & ThomasA. Lewandowski. (2006) Methods for Identifying a Default Cross-Species Scaling Factor. Human and Ecological Risk Assessment: An International Journal 12:6, pages 1094-1127.
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M. R. Shiran, N. J. Proctor, E. M. Howgate, K. Rowland-Yeo, G. T. Tucker & A. Rostami-Hodjegan. (2006) Prediction of metabolic drug clearance in humans: extrapolation allometric scaling. Xenobiotica 36:7, pages 567-580.
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Keith W Ward. (2005) Recent advances in pharmacokinetic extrapolation from preclinical data to humans. Expert Opinion on Drug Metabolism & Toxicology 1:4, pages 583-594.
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Chang Youn Cho, Beom Soo Shin, Ji Hoon Jung, Dong Hwan Kim, Kang Choon Lee, Soon-Young Han, Hyung Sik Kim, Byung Mu Lee & Sun Dong Yoo. (2002) Pharmacokinetic scaling of bisphenol A by species-invariant time methods. Xenobiotica 32:10, pages 925-934.
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A. G. Renwick. (2000) The use of safety or uncertainty factors in the setting of acute reference doses. Food Additives & Contaminants 17:7, pages 627-635.
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ChamE. Dallas, Xiao Mei Chen, Srinivasa Muralidhara, Peter Varkonyi, RandallL. Tackett & JamesV. Bruckner. (1995) Physiologically based pharmacokinetic model useful in prediction of the influence of species, dose, and exposure route on perchloroethylene pharmacokinetics. Journal of Toxicology and Environmental Health 44:3, pages 301-317.
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L. P. Balant & M. Gex-fabry. (1990) Review Physiological pharmacokinetic modelling. Xenobiotica 20:11, pages 1241-1257.
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R. M. J. Ings. (1990) Interspecies scaling and comparisons in drug development and toxicokinetics. Xenobiotica 20:11, pages 1201-1231.
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A. E. Tufenkji, M. Alvinerie, T. Pineau, C. Boulard & P. Galtier. (1988) Incidence of a subclinical fascioliasis on antipyrine clearance and metabolite excretion in sheep. Xenobiotica 18:4, pages 357-364.
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Harold Boxenbaum, C. Bruce McCullough & Frederick J. Di Carlo. (1985) Mortality Kinetics in Toxicology Studies. Drug Metabolism Reviews 16:3, pages 321-362.
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