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Research Article

Properties of Acyl Glucuronides: Implications for Studies of the Pharmacokinetics and Metabolism of Acidic Drugs

Ellen M. Faed MRC Toxicology Research Unit University of Otago School of Medicine, Dunedin, New Zealand
Pages 1213-1249 | Published online: 22 Sep 2008

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Jana Sádecká & Jana Netriová. (2005) Determination of Naproxen and its Metabolite, 6‐O‐Desmethylnaproxen, in Human Urine by Capillary Isotachophoresis. Journal of Liquid Chromatography & Related Technologies 28:18, pages 2887-2894.
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H. Fujino, I. Yamada, S. Shimada, M. Yoneda & J. Kojima. (2003) Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica 33:1, pages 27-41.
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A. Lo, R. S. Addison, W. D. Hooper & R. G. Dickinson. (2001) Disposition of naproxen, naproxen acyl glucuronide and its rearrangement isomers in the isolated perfused rat liver. Xenobiotica 31:6, pages 309-319.
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D. K. Dalvie & J. P. O'Donnell. (1999) Metabolism of CP-195,543, a leukotriene B4 receptor antagonist, in the Long-Evans rat and Cynomolgus monkey. Xenobiotica 29:11, pages 1123-1140.
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P. C. Smith & J. H. Liu. (1995) Covalent binding of suprofen to renal tissue of rat correlates with excretion of its acyl glucuronide. Xenobiotica 25:5, pages 531-540.
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P. Kestell, G. W. Rewcastle & B. C. Baguley. (1994) Disposition of the novel antitumour agent xanthenone-4-acetic acid in the mouse: Identification of metabolites and routes of elimination. Xenobiotica 24:7, pages 635-647.
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J. C. Ojingwa, H. Spahn-Langguth & L. Z. Benet. (1994) Irreversible binding of tolmetin to macromolecules via its glucuronide: Binding to blood constituents, tissue homogenates and subcellular fractions in vitro. Xenobiotica 24:6, pages 495-506.
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P. C. Smith & J. H. Liu. (1993) Covalent binding of suprofen acyl glucuronide to albumin in vitro. Xenobiotica 23:4, pages 337-348.
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J. P. Uetrecht. (1992) The Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug Reactions. Drug Metabolism Reviews 24:3, pages 299-366.
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Hildegard Spahn Langguth & Leslie Z. Benet. (1992) Acyl Glucuronides Revisited: Is the Glucuronidation Proces a Toxification as Well as a Detoxification Mechanism?. Drug Metabolism Reviews 24:1, pages 5-47.
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J. I. Macdonald, R. G. Dickinson, R. S. Reid, R. W. Edom, A. R. King & R. K. Verbeeck. (1991) Identification of a hydroxy metabolite of diflunisal in rat and human urine. Xenobiotica 21:11, pages 1521-1533.
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J. A. Watt, A. R. King & R. G. Dickinson. (1991) Contrasting systemic stabilities of the acyl and phenolic glucuronides of diflunisal in the rat. Xenobiotica 21:3, pages 403-415.
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F. Waldmeier, G. Kaiser, R. Ackermann, J. W. Faigle, J. Wagner, A. Barner & K. C. Lasseter. (1991) The disposition of [14C]-labelled benazepril HC1 in normal adult volunteers after single and repeated oral dose. Xenobiotica 21:2, pages 251-261.
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D. K. Patel, L. J. Notarianni & P. N. Bennett. (1990) Comparative metabolism of high doses of aspirin in man and rat. Xenobiotica 20:8, pages 847-854.
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J. A. Watt & R. G. Dickinson. (1990) Effects of blockage of urine and/or bile flow on diflunisal conjugation and disposition in rats. Xenobiotica 20:8, pages 835-845.
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Lance R. Pohl, J. G. Kenna, Hiroko Satoh, David Christ & Jackie L. Martin. (1989) Neoantigens Associated with Halothane Hepatitis. Drug Metabolism Reviews 20:2-4, pages 203-217.
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F. M. Kaspersen & C. A. A. Van Boeckel. (1987) A review of the methods of chemical synthesis of sulphate and glucuronide conjugates. Xenobiotica 17:12, pages 1451-1471.
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D. S. Wells, F. W. Janssen & H. W. Ruelius. (1987) Interactions between oxaprozin glucuronide and human serum albumin. Xenobiotica 17:12, pages 1437-1449.
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Frederick J. Di Carlo, Paul Bickart & Charles M. Auer. (1986) Structure-Metabolism Relationships (SMR) for the Prediction of Health Hazards by the Environmental Protection Agency. II. Application to Teratogenicity and Other Toxic Effects Caused by Aliphatic Acids. Drug Metabolism Reviews 17:3-4, pages 187-220.
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