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Research Article

Biotransformation of Phencyclidine

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Pages 285-320 | Published online: 22 Sep 2008

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Leandro Nóbrega & Ricardo Jorge Dinis-Oliveira. (2018) The synthetic cathinone α-pyrrolidinovalerophenone (α-PVP): pharmacokinetic and pharmacodynamic clinical and forensic aspects. Drug Metabolism Reviews 50:2, pages 125-139.
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Bernard Testa. (2015) Types of stereoselectivity in drug metabolism: a heuristic approach. Drug Metabolism Reviews 47:2, pages 239-251.
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R. T. STREEPER, P. G. PEARSON, Z. ZHAO, S. A. MIZSAK, P. E. SANDERS, L. C. WIENKERS & J. J. VRBANAC. (1997) In vitro metabolic transformations of 2,4- dipyrrolidinylp yrimidine : a chemical probe for P450-mediated oxidation of tirilazad mesylate. Xenobiotica 27:11, pages 1131-1145.
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R. Herber, R. Perrin, J.-M. Ziegler, J. Villoutreix, A. Minn & G. Siest. (1991) Identification of novel phencyclidine metabolites formed in vitro by rabbit microsomal metabolism. Xenobiotica 21:11, pages 1493-1499.
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Articles from other publishers (25)

Matthias J. Richter, Lea Wagmann, Pierce V. Kavanagh, Simon D. Brandt & Markus R. Meyer. (2022) In vitro metabolic fate of the synthetic cannabinoid receptor agonists (quinolin‐8‐yl 4‐methyl‐3‐(morpholine‐4‐sulfonyl)benzoate [QMMSB]) and (quinolin‐8‐yl 4‐methyl‐3‐((propan‐2‐yl)sulfamoyl)benzoate [QMiPSB]) including isozyme mapping and carboxylesterases activity testing. Drug Testing and Analysis 15:2, pages 181-191.
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Matthias J Richter, Lea Wagmann, Simon D Brandt & Markus R Meyer. (2022) In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists 2F-QMPSB and SGT-233 Including Isozyme Mapping and Carboxylesterases Activity Testing . Journal of Analytical Toxicology 46:9, pages e198-e206.
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Matthias J. Richter, Lea Wagmann, Tanja M. Gampfer, Simon D. Brandt & Markus R. Meyer. (2021) In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity. Metabolites 11:8, pages 509.
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Jason Wallach & Simon D. Brandt. 2018. New Psychoactive Substances. New Psychoactive Substances 261 303 .
Shayne P. Bisetto, Adriano B. Carregaro, André E.S. Nicolai, Thais F. Bressan, William P. Leal, Nathalia V. Xavier, Diego F. Leal & André F.C. Andrade. (2017) Hyaluronidase administered with xylazine–tiletamine–zolazepam into adipose tissue shortens recovery from anesthesia in pigs. Veterinary Anaesthesia and Analgesia 44:3, pages 594-599.
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Markus R. Meyer & Hans H. Maurer. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 429 463 .
Donald G. Barceloux. 2012. Medical Toxicology of Drug Abuse. Medical Toxicology of Drug Abuse 608 632 .
Christoph Sauer, Frank T. Peters, Claudia Haas, Markus R. Meyer, Giselher Fritschi & Hans H. Maurer. (2009) New designer drug α‐pyrrolidinovalerophenone (PVP): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques. Journal of Mass Spectrometry 44:6, pages 952-964.
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Christoph Sauer, Frank T. Peters, Roland F. Staack, Giselher Fritschi & Hans H. Maurer. (2008) Metabolism and toxicological detection of a new designer drug, N-(1-phenylcyclohexyl)propanamine, in rat urine using gas chromatography–mass spectrometry. Journal of Chromatography A 1186:1-2, pages 380-390.
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Christoph Sauer, Frank T. Peters, Roland F. Staack, Giselher Fritschi & Hans H. Maurer. (2008) New designer drugsN-(1-phenylcyclohexyl)-2-ethoxyethanamine (PCEEA) andN-(1-phenylcyclohexyl)-2-methoxyethanamine (PCMEA): Studies on their metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques. Journal of Mass Spectrometry 43:3, pages 305-316.
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Mikhail Kalinichev, Melanie J. Robbins, Elizabeth M. Hartfield, Peter R. Maycox, Susan H. Moore, Kevin M. Savage, Nigel E. Austin & Declan N.C. Jones. (2008) Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague–Dawley rats: A locomotor activity and gene induction study. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32:2, pages 414-422.
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James P. Driscoll, Katherine Kornecki, Joanna P. Wolkowski, Lou Chupak, Amit S. Kalgutkar & John P. O’Donnell. (2007) Bioactivation of Phencyclidine in Rat and Human Liver Microsomes and Recombinant P450 2B Enzymes: Evidence for the Formation of a Novel Quinone Methide Intermediate. Chemical Research in Toxicology 20:10, pages 1488-1497.
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Monica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg & Larry C. Wienkers. (2006) Mechanism of Inactivation of Human Cytochrome P450 2B6 by Phencyclidine. Drug Metabolism and Disposition 34:9, pages 1523-1529.
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Christoph Sauer, Frank T. Peters, Roland F. Staack, Giselher Fritschi & Hans H. Maurer. (2006) New designer drugN-(1-phenylcyclohexyl)-3-ethoxypropanamine (PCEPA): Studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques. Journal of Mass Spectrometry 41:8, pages 1014-1029.
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Mohamad Shebley, Monica I. Jushchyshyn & Paul F. Hollenberg. (2006) SELECTIVE PATHWAYS FOR THE METABOLISM OF PHENCYCLIDINE BY CYTOCHROME P450 2B ENZYMES: IDENTIFICATION OF ELECTROPHILIC METABOLITES, GLUTATHIONE, AND N -ACETYL CYSTEINE ADDUCTS . Drug Metabolism and Disposition 34:3, pages 375-383.
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Virginia McMillan Carr. (2006) Induced and constitutive heat shock protein expression in the olfactory system—A review, new findings, and some perspectives. Journal of Neurocytology 34:3-5, pages 269-293.
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Dragana Zivanovic, Olivera Stanojlovic, Slobodan Mirkovic & Veselinka Susic. (2005) Ontogenetic study of metaphit-induced audiogenic seizures in rats. Developmental Brain Research 155:1, pages 42-48.
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Vesna Pe?i?Branka Jana?Desanka Milanovi?Mirko Tomi?Rosica Veskov & Ljubisav Raki?. (2003) Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine. Behavioural Brain Research 147:1-2, pages 211-215.
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ARTHUR K. CHO, SHIZUO NARIMATSU & YOSHITO KUMAGAI. (1999) Metabolism of drugs of abuse by cytochromes P450. Addiction Biology 4:3, pages 283-301.
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Elizabeth M Laurenzana & S.Michael Owens. (1997) Brain microsomal metabolism of phencyclidine in male and female rats. Brain Research 756:1-2, pages 256-265.
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Yun Meng, Aron H. Lichtman, D.Troy Bridgen & Billy R. Martin. (1996) Pharmacological potency and biodisposition of phencyclidine via inhalation exposure in mice. Drug and Alcohol Dependence 43:1-2, pages 13-22.
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Alain Minn, Jean-François Ghersi-Egea, Rachel Perrin, Brigitte Leininger & Gérard Siest. (1991) Drug metabolizing enzymes in the brain and cerebral microvessels. Brain Research Reviews 16:1, pages 65-82.
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