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Drug Metabolism Reviews Volume 17, 1986 - Issue 1-2
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Research Article

Structure-Metabolism Relationships SMR) for the Prediction of Health Hazards)y the Environmental Protection Agency. I. Background for the Practice of Predictive Toxicology

Frederick J. Di Carlo Health and Environmental Review Division, TS 796 Environmental Protection Agency, Washington, DC, 20460
,
Paul Bickart Health and Environmental Review Division, TS 796 Environmental Protection Agency, Washington, DC, 20460
&
Charles M. Auer Health and Environmental Review Division, TS 796 Environmental Protection Agency, Washington, DC, 20460
Pages 171-184 | Published online: 22 Sep 2008

Citations (9)

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Read on this site (1)

CharlesM. Auer & DavidH. Gould. (1987) Carcinogenicity assessment and the role of structure activity relationship (SAR) analysis under TSCA section 5. Environmental Carcinogenesis Reviews 5:1, pages 29-71.
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Articles from other publishers (8)

Gang Yan, Jane Rose, Corie Ellison, Ashley M. Mudd, Xiaoling Zhang & Shengde Wu. (2023) Refine and Strengthen SAR-Based Read-Across by Considering Bioactivation and Modes of Action. Chemical Research in Toxicology.
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Katharina Brotzmann, Sylvia E. Escher, Paul Walker & Thomas Braunbeck. (2022) Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues. Archives of Toxicology 96:11, pages 3033-3051.
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Konstantin V. Balakin, Sean Ekins, Andrey Bugrim, Yan A. Ivanenkov, Dmitry Korolev, Yuri V. Nikolsky, Andrey A. Ivashchenko, Nikolay P. Savchuk & Tatiana Nikolskaya. (2004) QUANTITATIVE STRUCTURE-METABOLISM RELATIONSHIP MODELING OF METABOLIC N -DEALKYLATION REACTION RATES . Drug Metabolism and Disposition 32:10, pages 1111-1120.
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Yin-tak Woo, David Y. Lai, Mary F. Argus & Joseph C. Arcos. (1995) Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals. Toxicology Letters 79:1-3, pages 219-228.
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P.M. Wagner, J.V. Nabholz & R.J. Kent. (1995) The new chemicals process at the Environmental Protection Agency (EPA): structure-activity relationships for hazard identification and risk assessment. Toxicology Letters 79:1-3, pages 67-73.
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Yin-tak Woo, Gregg Polansky, Joseph C. Arcos, Jeff Stokes DuBose & Mary F. Argus. 1996. Chemical Induction of Cancer. Chemical Induction of Cancer 185 203 .
Y T WooF J Di CarloJ C ArcosM F ArgusG PolanskyJ DuBose. (1994) Assessment of carcinogenic hazard of chemical mixtures through analysis of binary chemical interaction data.. Environmental Health Perspectives 102:suppl 9, pages 113-118.
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C M AuerJ V NabholzK P Baetcke. (1990) Mode of action and the assessment of chemical hazards in the presence of limited data: use of structure-activity relationships (SAR) under TSCA, Section 5.. Environmental Health Perspectives 87, pages 183-197.
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