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Research Article

Chemical Teratogenesis: Testing Methods and the Role of Metabolism

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Pages 221-260 | Published online: 22 Sep 2008

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Josephine Kugler, Bettina Huhse, Tewes Tralau & Andreas Luch. (2017) Embryonic stem cells and the next generation of developmental toxicity testing. Expert Opinion on Drug Metabolism & Toxicology 13:8, pages 833-841.
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So Hee Kim, Soon Sun Kim, Oran Kwon, Kyung Hee Sohn, Seung Jun Kwack, Yo Woo Choi, Soon Young Han, Myung Koo Lee & Kui Lea Park. (2002) EFFECTS OF DIBUTYL PHTHALATE AND MONOBUTYL PHTHALATE ON CYTOTOXICITY AND DIFFERENTIATION IN CULTURED RAT EMBRYONIC LIMB BUD CELLS; PROTECTION BY ANTIOXIDANTS. Journal of Toxicology and Environmental Health, Part A 65:5-6, pages 461-472.
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Mont R. Juchau, Qwihee P. Lee & Alan G. Fantel. (1992) Xenobiotic Biotransfor Mation/Bioactivation in Organogenesis-Stage Conceptal Tissues: Implications for Embryotoxicity and Teratogenesis. Drug Metabolism Reviews 24:2, pages 195-238.
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L. P. Brown, D. F. V. Lewis, O. P. Flint, T. C. Orton & G. G. Gibson. (1989) Teratogenicity of phenylhydantoins in an in vitro system: Molecular orbital-generated quantitative structure-toxicity relationships. Xenobiotica 19:12, pages 1471-1481.
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Articles from other publishers (13)

Susanne Bremer, Cristian Pellizzer, Sandra Coecke, Martin Paparella & Paolo Catalani. (2019) Detection of the Embryotoxic Potential of Cyclophosphamide by Using a Combined System of Metabolic Competent Cells and Embryonic Stem Cells. Alternatives to Laboratory Animals 30:1, pages 77-85.
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Rafael A. Ponce. (2001) Micromass Cultures in Teratology. Current Protocols in Toxicology 7:1.
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James Schardein. 2000. Chemically Induced Birth Defects, Third Edition. Chemically Induced Birth Defects, Third Edition 1 66 .
L.A.G.J.M. van Aerts, S.J.M. Hahné, A.G.M. Oostendorp, J.C.L.M. Pertijs, P.H.S. Fijneman, R.P. Bos, J.H.J. Copius Peereboom & J. Noordhoek. (1993) Sex difference in Aroclor 1254 induction of rat hepatocytes: Consequences for in vitro embryotoxicity and mutagenicity of cyclophosphamide. Toxicology in Vitro 7:6, pages 769-775.
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Stephen G. Whittaker & Elaine M. Faustman. (1991) Effects of albendazole and albendazole sulfoxide on cultures of differentiating rodent embryonic cells. Toxicology and Applied Pharmacology 109:1, pages 73-84.
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Mont R. Juchau, Craig Harris, Kevin L. Stark, Qwihee P. Lee, Hsueh-Ying L. Yang, Moses J. Namkung & Alan G. Fantel. (1991) Cytochrome P450-dependent bioactivation of prodysmorphogens in cultured conceptuses. Reproductive Toxicology 5:3, pages 259-263.
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W.J. Bacon, P.A. Duffy & K. Jones. (1990) Studies on variability of the micromass teratogen test. Toxicology in Vitro 4:4-5, pages 577-581.
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Frank Welsch. 1990. Issues and Reviews in Teratology. Issues and Reviews in Teratology 115 153 .
Craig Harris, Kevin L. Stark, Daniel L. Luchtel & Mont R. Juchau. (1989) Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: Evidence for catechol metabolites as proximate dysmorphogens. Toxicology and Applied Pharmacology 101:3, pages 432-446.
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Hsueh-Ying L. Yang, Moses J. Namkung & Mont R. Juchau. (1989) Immunodetection, immunoinhibition, immunoquantitation and biochemical analyses of cytochrome P-450IA1 in tissues of the rat conceptus during the progression of organogenesis. Biochemical Pharmacology 38:22, pages 4027-4036.
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George P. Daston & Robert A. D'amato. (2017) In Vitro Techniques in Teratology. Toxicology and Industrial Health 5:3, pages 555-585.
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L.P. Brown, J.R. Foster, T.C. Orton, O.P. Flint & G.G. Gibson. (1989) Inducibility and functionality of rat embryonic/foetal cytochrome P-450: A study of differentiating limb-bud and mid-brain cells in vitro. Toxicology in Vitro 3:4, pages 253-260.
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L.P. Brown, J.R. Foster, T.C. Orton, O.P. Flint & G.G. Gibson. (1989) Localization and identification of cytochrome P-450 in differentiating rat embryo cells in vitro and in foetal tissue in vivo by immunocytochemistry. Toxicology in Vitro 3:4, pages 245-252.
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