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Research Article

Mechanisms of the Inhibition of Cytochrome P 450-Mediated Drug Oxidation by Therapeutic Agents

Pages 55-81 | Published online: 22 Sep 2008

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Yasuhiro Masubuchi & Toshiharu Horie. (2007) Toxicological Significance of Mechanism-Based Inactivation of Cytochrome P450 Enzymes by Drugs. Critical Reviews in Toxicology 37:5, pages 389-412.
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N. Ishiguro, C. Senda, W. Kishimoto, K. Sakai, Y. Funae, T. Igarashi. (2000) Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes. Xenobiotica 30:1, pages 71-80.
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O. PELKONEN, J. MÄEENPÄEÄ, P. TAAVITSAINEN, A. RAUTIO & H. RAUNIO. (1998) Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28:12, pages 1203-1253.
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D. A. SMITH, S. M. ABEL, R. HYLAND & B. C. JONES. (1998) Human cytochrome P450s: selectivity and measurement in vivo. Xenobiotica 28:12, pages 1095-1128.
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Bernard Testa. (1990) Mechanisms of inhibition of xenobiotic-metabolizing enzymes. Xenobiotica 20:11, pages 1129-1137.
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