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Drug Metabolism Reviews Volume 19, 1988 - Issue 2
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Research Article

Disposition of hexobarbital: 15 years of an intriguing model substrate

M. Van Der Graaff Department of Pharmaceutics, Organon International B. V., Oss, The Netherlands
,
N. P. E. Vermeulen Department of Pharmacochemistry, Free University, Amsterdam De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands
&
D. D. Breimer Department of Pharmacology Center for Biopharmaceutical Sciences, State University of Leiden, The Netherlands
Pages 109-164 | Published online: 22 Sep 2008

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Arnold R. Goeptar, Heleen Scheerens & Nico P. E. Vermeulen. (1995) Oxygen and Xenobiotic Reductase Activities of Cytochrome P450. Critical Reviews in Toxicology 25:1, pages 25-65.
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R. Takenoshita, T. Nakamura & S. Toki. (1993) Hexobarbital metabolism: a new metabolic pathway to produce 1,5-dimethylbarbituric acid and cyclohexenone-glutathione adduct via 3′-oxohexobarbital. Xenobiotica 23:8, pages 925-934.
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Articles from other publishers (10)

Santhosh M. Baby, Lisa H. Tanner, Joseph F. Discala, Ryan B. Gruber, Yee-Hsee Hsieh & Stephen J. Lewis. (2022) Systemic Administration of Tempol, a Superoxide Dismutase Mimetic, Augments Upper Airway Muscle Activity in Obese Zucker Rats. Frontiers in Pharmacology 13.
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. 2005. Drug Metabolism. Drug Metabolism 41 128 .
Iftekhar Mahmood. (2002) Interspecies Scaling: Predicting Oral Clearance in Humans. American Journal of Therapeutics 9:1, pages 35-42.
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P. Pappas, P. Stephanou, V. Vasiliou & M. Marselos. (1998) Zoxazolamine-induced paralysis in two rat substrains: differences in hepatic drug metabolism. European Journal of Drug Metabolism and Pharmacokinetics 23:4, pages 461-467.
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Kees Groen & Douwe D. Breimer. 1996. Cytochrome P450, Part B. Cytochrome P450, Part B 169 177 .
O. Pelkonen & D. D. Breimer. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 289 332 .
F. von Bruchhausen, S. Ebel, E. Hackenthal, G. Dannhardt, A. W. Frahm, U. Holzgrabe, K. Keller, E. Nürnberg, H. Rimpler, G. Schneider, P. Surmann, H. U. Wolf & G. Wurm. 1993. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 401 515 .
Chandra Prakash, Adedayo Adedoyin, Grant R. Wilkinson & Ian A. Blair. (1991) Enantiospecific quantification of hexobarbital and its metabolites in biological fluids by gas chromatography/electron capture negative ion chemical ionization mass spectrometry. Biological Mass Spectrometry 20:9, pages 559-564.
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H.J. Barton'J.T. Bojarski, A. Żurowska & L. Ekiert. (1990) Photoinduced stereospecific formation of substituted hydantoin from hexobarbital. Journal of Photochemistry and Photobiology A: Chemistry 54:2, pages 187-196.
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Grant R. Wilkinson, F. Peter Guengerich & Robert A. Branch. (1989) Genetic polymorphism of S-mephenytoin hydroxylation. Pharmacology & Therapeutics 43:1, pages 53-76.
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