Citations (59)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Rafik Karaman. (2014) Using predrugs to optimize drug candidates. Expert Opinion on Drug Discovery 9:12, pages 1405-1419.
Read now
Read now
Federica Vacondio, Claudia Silva, Marco Mor & Bernard Testa. (2010) Qualitative structure-metabolism relationships in the hydrolysis of carbamates. Drug Metabolism Reviews 42:4, pages 551-589.
Read now
Read now
Articles from other publishers (57)
Chinmayee Choudhury, Vivek Kumar & Rakesh Kumar. (2023) smProdrugs: A repository of small molecule prodrugs. European Journal of Medicinal Chemistry 249, pages 115153.
Crossref
Crossref
Giredhar Muthiah & Amit Jaiswal. (2021) Can the Union of Prodrug Therapy and Nanomedicine Lead to Better Cancer Management?. Advanced NanoBiomed Research 2:1, pages 2100074.
Crossref
Crossref
Johannes Karges, Ryjul W. Stokes & Seth M. Cohen. (2021)
Photorelease of a metal-binding pharmacophore from a Ru(
ii
) polypyridine complex
. Dalton Transactions 50:8, pages 2757-2765.
Crossref
Crossref
Mohamed Ibrahim Halawa, Islam M. Mostafa, Guoxing Wu & Bing Shi Li. (2021) Amplified anodic electrogenerated chemiluminescence of tris(2,2′-bipyridyl)ruthenium(II) for ultrasensitive detection of bambuterol: Application to content uniformity testing. Journal of Electroanalytical Chemistry 880, pages 114881.
Crossref
Crossref
Ana Matošević & Anita Bosak. (2020) Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents. Archives of Industrial Hygiene and Toxicology 71:4, pages 285-299.
Crossref
Crossref
Jarkko Rautio, Nicholas A. Meanwell, Li Di & Michael J. Hageman. (2018) The expanding role of prodrugs in contemporary drug design and development. Nature Reviews Drug Discovery 17:8, pages 559-587.
Crossref
Crossref
Sherif M. Eid, Mohamed K. Abd El-Rahman, Mohamed R. Elghobashy & Khadiga M. Kelani. (2018) Attenuated Total Reflectance Fourier Transformation Infrared spectroscopy fingerprinted online monitoring of the kinetics of circulating Butyrylcholinesterase enzyme during metabolism of bambuterol. Analytica Chimica Acta 1005, pages 70-80.
Crossref
Crossref
Raoul Walther, Jarkko Rautio & Alexander N. Zelikin. (2017) Prodrugs in medicinal chemistry and enzyme prodrug therapies. Advanced Drug Delivery Reviews 118, pages 65-77.
Crossref
Crossref
Meng Zhou, Rong-Hong Zhang, Min Wang, Guo-Bo Xu & Shang-Gao Liao. (2017) Prodrugs of triterpenoids and their derivatives. European Journal of Medicinal Chemistry 131, pages 222-236.
Crossref
Crossref
Jonas H Fagerberg & Christel AS Bergström. (2015) Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions. Therapeutic Delivery 6:8, pages 935-959.
Crossref
Crossref
Arun K. Ghosh & Margherita Brindisi. (2015) Organic Carbamates in Drug Design and Medicinal Chemistry. Journal of Medicinal Chemistry 58:7, pages 2895-2940.
Crossref
Crossref
Marco Pistolozzi, Huaqiao Du, Hong Wei & Wen Tan. (2015) Stereoselective Inhibition of Human Butyrylcholinesterase by the Enantiomers of Bambuterol and Their Intermediates. Drug Metabolism and Disposition 43:3, pages 344-352.
Crossref
Crossref
Yuzhou Wu, David Y. W. Ng, Seah Ling Kuan & Tanja Weil. (2015) Protein–polymer therapeutics: a macromolecular perspective. Biomaterials Science 3:2, pages 214-230.
Crossref
Crossref
Rafik Karaman. (2013) Prodrugs Design Based on Inter- and Intramolecular Chemical Processes. Chemical Biology & Drug Design 82:6, pages 643-668.
Crossref
Crossref
Mario Cazzola, Clive P. Page, Luigino Calzetta & M. Gabriella Matera. (2012) Pharmacology and Therapeutics of Bronchodilators. Pharmacological Reviews 64:3, pages 450-504.
Crossref
Crossref
Kristiina M. Huttunen, Hannu Raunio & Jarkko Rautio. (2011) Prodrugs—from Serendipity to Rational Design. Pharmacological Reviews 63:3, pages 750-771.
Crossref
Crossref
Jarkko Rautio. 2010. Prodrugs and Targeted Delivery. Prodrugs and Targeted Delivery
1
30
.
Shayne Cox GadTomi Järvinen, Jarkko Rautio, Mar Masson & Thorsteinn Loftsson. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Bernard Testa. 2008. Drug Bioavailability. Drug Bioavailability
559
570
.
Gao Cao, Ai-Xi Hu, Kang-Sheng Zou, Ling Xu, Jian-Long Chen & Wen Tan. (2008) Highly enantioselective synthesis, crystal structure, and circular dichroism spectroscopy of (R)-bambuterol hydrochloride. Chirality 20:7, pages 856-862.
Crossref
Crossref
Jarkko Rautio, Hanna Kumpulainen, Tycho Heimbach, Reza Oliyai, Dooman Oh, Tomi Järvinen & Jouko Savolainen. (2008) Prodrugs: design and clinical applications. Nature Reviews Drug Discovery 7:3, pages 255-270.
Crossref
Crossref
B. Testa. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
1009
1041
.
Sundeep S. Dhareshwar & Valentino J. Stella. 2007. Prodrugs. Prodrugs
731
799
.
Valentino J. Stella. 2007. Prodrugs. Prodrugs
3
33
.
Ivana Gazić, Anita Bosak, Goran Šinko, Vladimir Vinković & Zrinka Kovarik. (2006) Preparative HPLC separation of bambuterol enantiomers and stereoselective inhibition of human cholinesterases. Analytical and Bioanalytical Chemistry 385:8, pages 1513-1519.
Crossref
Crossref
Valentino J. Stella. 2006. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery
221
242
.
Bernard Testa. (2004) Prodrug research: futile or fertile?. Biochemical Pharmacology 68:11, pages 2097-2106.
Crossref
Crossref
Yacov Ashani. (2000) Prospective of human butyrylcholinesterase as a detoxifying antidote and potential regulator of controlled-release drugs. Drug Development Research 50:3-4, pages 298-308.
Crossref
Crossref
Doris Østergaard, Søren N. Rasmussen, Jørgen Viby-Mogensen, Niels A. Pedersen & Rikke Boysen. (2000) The Influence of Drug-induced Low Plasma Cholinesterase Activity on the Pharmacokinetics and Pharmacodynamics of Mivacurium. Anesthesiology 92:6, pages 1581-1587.
Crossref
Crossref
Johan Rosenborg,Per Larsson & Lars Nyberg. (2001) Pharmacokinetics of bambuterol during oral administration of plain tablets and solution to healthy adults. British Journal of Clinical Pharmacology 49:3, pages 199-206.
Crossref
Crossref
Hans Ahlström, Josefino Alvero, Rita Alvero, Roberto Espos, Liberty Fajutrao, Jocelyn Herrera, Bengt Kjellman, Josef Kubista, Carolina Leviste, Peter Meyer, Göran Oldæus, Areerat Siricururat, Pakit Vichyanond, Göran Wettrell, Ellick Wong, Lena Laxmyr, Lars Nyberg, Håkan Olsson, Eva Weibull & Johan Rosenborg. (2001) Pharmacokinetics of bambuterol during oral administration to asthmatic children. British Journal of Clinical Pharmacology 48:3, pages 299-308.
Crossref
Crossref
Parveen Khan, Sayara Abbas, Robert H.J Hargreaves, Robert Caffrey, Victoria Megram & Alan McGown. (1999) Development and validation of a sensitive solid-phase extraction and high-performance liquid chromatographic assay for the novel bio-reductive anti-tumor agent RH1 in human and mouse plasma. Journal of Chromatography B: Biomedical Sciences and Applications 729:1-2, pages 287-295.
Crossref
Crossref
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst & D. Youssef. 1999. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis
127
188
.
Ulla Bang, Lars Nyberg, Johan Rosenborg & Jørgen Viby‐Mogensen. (2002) Pharmacokinetics of bambuterol in subjects homozygous for the atypical gene for plasma cholinesterase. British Journal of Clinical Pharmacology 45:5, pages 479-484.
Crossref
Crossref
Lars Nyberg, Johan Rosenborg, Eva Weibull, Sven Jönsson, Britt‐Marie Kennedy & Marita Nilsson. (2002) Pharmacokinetics of bambuterol in healthy subjects. British Journal of Clinical Pharmacology 45:5, pages 471-478.
Crossref
Crossref
Leif-Ake Svensson. 1998. Treatment of Asthma: The long-acting beta-2-agonists. Treatment of Asthma: The long-acting beta-2-agonists
71
90
.
Radhakrishnan P. Iyer, Nan-hui Ho, Dong Yu & Sudhir Agrawal. (1997) Bioreversible oligonucleotide conjugates by site-specific derivatization. Bioorganic & Medicinal Chemistry Letters 7:7, pages 871-876.
Crossref
Crossref
Mary T. Obermeier, Saeho Chong, Sandra A. Dando, Anthony M. Marino, Denis E. Ryono, Anne Starrett-Arroyo, Gerald C. DiDonato, Bethanne M. Warrack, Ronald E. White & Richard A. Morrison. (1996) Prodrugs of BMS-183920: Metabolism and Permeability Considerations. Journal of Pharmaceutical Sciences 85:8, pages 828-833.
Crossref
Crossref
Carl G. A. Persson. (1995) Astute Observers Discover Anti-Asthma Drugs. Pharmacology & Toxicology 77, pages 7-15.
Crossref
Crossref
Doris Østergaard, Ulla Bang, Niels A. Pedersen & Jørgen Viby-Mogensen. 1995. Muscle Relaxants. Muscle Relaxants
362
362
.
Karin Fredholt Thomsen, Flemming Strøm, Brian Vittorio Sforzini, Mikael Begtrup & Niels Mørk. (1994) Evaluation of phenyl carbamates of ethyl diamines as cyclization-activated prodrug forms for protecting phenols against first-bass metabolism. International Journal of Pharmaceutics 112:2, pages 143-152.
Crossref
Crossref
Leif-Å. Svensson. (1994) Toward lung-selective β2-adrenergic bronchodilator prodrugs. Advanced Drug Delivery Reviews 14:2-3, pages 319-330.
Crossref
Crossref
Spyridon Vamvakas & M.W. Anders. 1994.
479
499
.
B. Rosberg, C. Schr�der, L. Nyberg, J. Rosenborg & J. E. Wir�n. (1993) Bambuterol and terbutaline in human cerebrospinal fluid and plasma. European Journal of Clinical Pharmacology 45:2, pages 147-150.
Crossref
Crossref
Karin Fredholt Thomsen & Hans Bundgaard. (1993) Cyclization-activated phenyl carbamate prodrug forms for protecting phenols against first-pass metabolism. International Journal of Pharmaceutics 91:1, pages 39-49.
Crossref
Crossref
Deanna L. Kroetz, O. Wesley McBride & Frank J. Gonzalez. (2002) Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms. Biochemistry 32:43, pages 11606-11617.
Crossref
Crossref
E Toja, C Bonetti, A Butti, P Hunt, M Fortin, F Barzaghi, ML Formento, A Maggioni, A Nencioni & G Galliani. (1992) 1-substituted-1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-alkyloximes as novel orally active and long-lasting muscarinic cholinergic agonists. European Journal of Medicinal Chemistry 27:5, pages 519-526.
Crossref
Crossref
Joan Hansen, Niels Mørk & Hans Bundgaard. (1992) Phenyl carbamates of amino acids as prodrug forms for protecting phenols against first-pass metabolism. International Journal of Pharmaceutics 81:2-3, pages 253-261.
Crossref
Crossref
Kristian T. Hansen, Jens A. Jansen, Helle Mengel, Jeppe V. Christensen & Hans Bundgaard. (1992) Enhanced bioavailability of a new class of dopamine D-1 antagonists following oral administration of their carbamic acid ester prodrugs to dogs. International Journal of Pharmaceutics 79:1-3, pages 205-212.
Crossref
Crossref
Claes Lindberg, Jan Paulson & Ann Blomqvist. (1991) Evaluation of an automated thermospray liquid chromatography-mass spectrometry system for quantitative use in bioanalytical chemistry. Journal of Chromatography A 554:1-2, pages 215-226.
Crossref
Crossref
Kristian T. Hansen, Peter Faarup & Hans Bundgaard. (1991) Carbamate Ester Prodrugs of Dopaminergic Compounds: Synthesis, Stability, and Bioconversion. Journal of Pharmaceutical Sciences 80:8, pages 793-798.
Crossref
Crossref
Anders Tunek, Elisabeth Hjertberg & Jörgen Viby Mogensen. (1991) Interactions of bambuterol with human serum cholinesterase of the genotypes EuEu (normal), EaEa (atypical) and EuEa. Biochemical Pharmacology 41:3, pages 345-348.
Crossref
Crossref
U. Bang, J. Viby‐Mogensen & J. E. Wirén. (2008) The effect of bambuterol on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in subjects heterozygous for abnormal plasma cholinesterase. Acta Anaesthesiologica Scandinavica 34:7, pages 600-604.
Crossref
Crossref
U. Bang, J. Viby‐Mogensen, J. E. Wirén & L. Theil Skovgaard. (2008) The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients. Acta Anaesthesiologica Scandinavica 34:7, pages 596-599.
Crossref
Crossref
P. Staun, C. Lennmarken, L. I. Eriksson & J-E. Wirén. (1990) The influence of 10 mg and 20 mg of bambuterol on the duration of succinylcholine-induced neuromuscular blockade. Acta Anaesthesiologica Scandinavica 34:6, pages 498-500.
Crossref
Crossref
Claes Lindberg, Sven Jönsson, Jan Paulson & Anders Tunek. (1990) Determination of bambuterol, a prodrug of terbutaline, in plasma and urine by gas chromatography/mass spectrometry. Biological Mass Spectrometry 19:4, pages 218-224.
Crossref
Crossref
Mohamed S. Rashed, Paul G. Pearson, Deog‐Hwa Han & Thomas A. Baillie. (2005) Application of liquid chromatography/thermospray mass spectrometry to studies on the formation of glutathione and cysteine conjugates from monomethylcarbamate metabolites of bambuterol. Rapid Communications in Mass Spectrometry 3:10, pages 360-363.
Crossref
Crossref