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Drug Metabolism Reviews Volume 20, 1989 - Issue 1
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Research Article

Influence of Aging on Chemically Induced Hepato-Toxicity: Role of Age-Related Changes in Metabolism

Lora E. Rikans Department of Pharmacology, University of Oklahoma College of Medicine, P.O. Box 26901, Oklahoma City, Oklahoma, 73190
Pages 87-110 | Published online: 22 Sep 2008

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Mehdi Ahmadian, Valiollah Dabidi Roshan & Anthony S. Leicht. (2018) Age-related effect of aerobic exercise training on antioxidant and oxidative markers in the liver challenged by doxorubicin in rats. Free Radical Research 52:7, pages 775-782.
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Sarah N Hilmer. (2008) ADME-tox issues for the elderly. Expert Opinion on Drug Metabolism & Toxicology 4:10, pages 1321-1331.
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K. Saito, H. Kaneko, K. Sato, A. Yoshitake & H. Yamada. (1991) Age-related changes in metabolism of diethofencarb: Relationship between metabolism in rat and hepatic drug-metabolizing enzyme activities. Xenobiotica 21:5, pages 575-582.
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Articles from other publishers (27)

Robert K. Gieseler, Thomas Schreiter & Ali Canbay. (2023) The Aging Human Liver: The Weal and Woe of Evolutionary Legacy. Zeitschrift für Gastroenterologie 61:01, pages 83-94.
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G.L. Kedderis. 2018. Comprehensive Toxicology. Comprehensive Toxicology 128 142 .
Bruce A. Fowler. 2017. Electronic Waste. Electronic Waste 55 61 .
Christopher R. Carpenter & Michael E. Stern. (2010) Emergency Orthogeriatrics: Concepts and Therapeutic Alternatives. Emergency Medicine Clinics of North America 28:4, pages 927-949.
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G.L. Kedderis. 2010. Comprehensive Toxicology. Comprehensive Toxicology 137 151 .
C-Y Oliver Chen & Jeffrey Blumberg. 2008. Phytochemicals. Phytochemicals 19 37 .
Katsumi MORISHITA, Yumiko MIZUKAWA, Toshihiko KASAHARA, Manabu OKUYAMA, Kayoko TAKASHIMA, Naoki TORITSUKA, Toshikazu MIYAGISHIMA, Taku NAGAO & Tetsuro URUSHIDANI. (2006) GENE EXPRESSION PROFILE IN LIVER OF DIFFERING AGES OF RATS AFTER SINGLE ORAL ADMINISTRATION OF ACETAMINOPHEN. The Journal of Toxicological Sciences 31:5, pages 491-507.
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B Murali, M.C Korrapati, Alan Warbritton, John R Latendresse & Harihara M Mehendale. (2004) Tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity. Mechanisms of Ageing and Development 125:6, pages 421-435.
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Michael Fountoulakis, Maria-Cristina de Vera, Flavio Crameri, Franziska Boess, Rodolfo Gasser, Silvio Albertini & Laura Suter. (2002) Modulation of Gene and Protein Expression by Carbon Tetrachloride in the Rat Liver. Toxicology and Applied Pharmacology 183:1, pages 71-80.
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Marcello Lotti. (2002) Age-related sensitivity of the nervous system to neurotoxic insults. Toxicology Letters 127:1-3, pages 183-187.
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Lora E. Rikans, Lacinda A. DeCicco, K.Roger Hornbrook & Tetsuo Yamano. (1999) Effect of age and carbon tetrachloride on cytokine concentrations in rat liver. Mechanisms of Ageing and Development 108:2, pages 173-182.
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Andrey L Sukhodub & Vladimir I Padalko. (1999) Age-dependent changes in rat liver microsomal membrane structure and functions under benzene treatment. Mechanisms of Ageing and Development 106:3, pages 273-282.
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M G SoniH M Mehendale. (1998) Role of tissue repair in toxicologic interactions among hepatotoxic organics.. Environmental Health Perspectives 106:suppl 6, pages 1307-1317.
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A DaluP S RaoH M Mehendale. (1998) Colchicine antimitosis abolishes resiliency of postnatally developing rats to chlordecone-amplified carbon tetrachloride hepatotoxicity and lethality.. Environmental Health Perspectives 106:9, pages 597-606.
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Lacinda A DeCicco, Lora E Rikans, Carrie G Tutor & K.Roger Hornbrook. (1998) Serum and liver concentrations of tumor necrosis factor α and interleukin-1β following administration of carbon tetrachloride to male rats. Toxicology Letters 98:1-2, pages 115-121.
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Lora E Rikans & K.Roger Hornbrook. (1997) Age-related susceptibility to hepatotoxicants. Environmental Toxicology and Pharmacology 4:3-4, pages 339-344.
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D. Remirez, R. González, S. Rodriguez, O. Ancheta, J.C. Bracho, A. Rosado, E. Rojas & M.E. Ramos. (1997) Protective effects of Propolis extract on allyl alcohol-induced liver injury in mice. Phytomedicine 4:4, pages 309-314.
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Diadelis Remirez, Jan N.M Commandeur, Ed Groot, Ricardo Gonzalez, Sandra Rodriguez, Odelsa Ancheta, Enis Rojas, Ma Elena Ramos & Nico P.E Vermeulen. (1997) Protective effects of lobenzarit against allyl alcohol-induced hepatotoxicity in mice and rats. Environmental Toxicology and Pharmacology 3:2, pages 129-135.
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PW van Vliet & J. de Jongh. (2016) Biokinetics and biokinetic models in risk assessment. Human & Experimental Toxicology 15:10, pages 799-809.
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Abraham Dalu & Harihara M Mehendale. (1996) Efficient tissue repair underlies the resiliency of postnatally developing rats to chlordecone + CCl4 hepatotoxicity. Toxicology 111:1-3, pages 29-42.
Crossref
K. Kitani. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 341 366 .
Abraham Dalu, Gerald M. Cronin, Beverly D. Lyn‐Cook & Harihara M. Mehendale. (2006) Age‐related differences in TGF‐α and proto‐oncogenes expression in rat liver after a low dose of carbon tetrachloride. Journal of Biochemical Toxicology 10:5, pages 259-264.
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Ming W. Chou, Joe G. Shaddock, Jin Kong, Ronald W. Hart & Dan A. Casciano. (1995) Effect of dietary restriction on partial hepatectomy-induced liver regeneration of aged F344 rats. Cancer Letters 91:2, pages 191-197.
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Sattar K. Abdul-Hussain & Harihara M. Mehendale. (1992) Ongoing hepatocellular regeneration and resiliency toward galactosamine hepatotoxicity. Archives of Toxicology 66:10, pages 729-742.
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Wesley W. Day & Myron Weiner. (1991) Inhibition of hepatic drug metabolism and carbon tetrachloride toxicity in Fischer-344 rats by exercise. Biochemical Pharmacology 42:1, pages 181-184.
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Lora E. Rikans, Danny R. Moore & Cynthia D. Snowden. (1991) Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver. Biochimica et Biophysica Acta (BBA) - General Subjects 1074:1, pages 195-200.
Crossref
Sattar K. Abdul-Hussain & Harihara M. Mehendale. (1991) Studies on the age-dependent effects of galactosamine in primary rat hepatocyte cultures. Toxicology and Applied Pharmacology 107:3, pages 504-513.
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