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Research Article

Oxicams: Metabolic Disposition in Man and Animals

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Pages 255-276 | Published online: 22 Sep 2008

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Amit S Kalgutkar & John R Soglia. (2005) Minimising the potential for metabolic activation in drug discovery. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 91-142.
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Zeki Atkopar & Muzaffer Tunçel. (1996) The Polarographic Determination of Tenoxicam in the Pharmaceutical Preparations. Analytical Letters 29:13, pages 2383-2397.
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J. Schmid, U. Busch, G. Trummlitz, A. Prox, S. Kaschke & H. Wachsmuth. (1995) Meloxicam: metabolic profile and biotransformation products in the rat. Xenobiotica 25:11, pages 1219-1236.
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Ridho Asra & Alan M Jones. (2023) Green electrosynthesis of drug metabolites. Toxicology Research 12:2, pages 150-177.
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Xue Bai, Dan Qin & Lijun Yang. (2021) Importance of substituents in ring opening: a DFT study on a model reaction of thiazole to thioamide. Journal of Molecular Modeling 27:3.
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Hussein O. Ammar, Magdy Ibrahim, Azza A. Mahmoud, Rehab N. Shamma & Nada M. El Hoffy. (2017) Non-ionic Surfactant Based In Situ Forming Vesicles as Controlled Parenteral Delivery Systems. AAPS PharmSciTech 19:3, pages 1001-1010.
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Qiao Xing, Jia Song, Xiuhua You, Dongling Xu, Kexin Wang, Jiaqi Song, Qin Guo, Pengyu Li, Chuanbin Wu & Haiyan Hu. (2016) Microemulsions containing long-chain oil ethyl oleate improve the oral bioavailability of piroxicam by increasing drug solubility and lymphatic transportation simultaneously. International Journal of Pharmaceutics 511:2, pages 709-718.
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Sally A. Helmy & Heba M. El-Bedaiwy. (2014) Piroxicam immediate release formulations: A fasting randomized open-label crossover bioequivalence study in healthy volunteers. Clinical Pharmacology in Drug Development 3:6, pages 466-471.
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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach & Dennis A. Smith. 2012. Reactive Drug Metabolites. Reactive Drug Metabolites 269 312 .
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Veska Russeva, Zvetanka Zhivkova, Krassimira Prodanova & Rositza Rakovska. (1999) Protein Binding of Piroxicam Studied by Means of Affinity Chromatography and Circular Dichroism. Journal of Pharmacy and Pharmacology 51:1, pages 49-52.
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Annica Tevell Åberg, Charlotte Olsson, Ulf Bondesson & Mikael Hedeland. (2009) A mass spectrometric study on meloxicam metabolism in horses and the fungus Cunninghamella elegans, and the relevance of this microbial system as a model of drug metabolism in the horse . Journal of Mass Spectrometry 44:7, pages 1026-1037.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:9, pages 2031-2122.
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A. David Rodrigues. (2005) IMPACT OF CYP2C9 GENOTYPE ON PHARMACOKINETICS: ARE ALL CYCLOOXYGENASE INHIBITORS THE SAME?: TABLE 1 . Drug Metabolism and Disposition 33:11, pages 1567-1575.
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H. L. HEEB, R. CHUN, D. E. KOCH, L. MOORE, M. RADLINSKY, M. CORSE, M. A. PELLERIN, L. GARRETT & R. P. HUNTER. (2005) Multiple dose pharmacokinetics and acute safety of piroxicam and cimetidine in the cat. Journal of Veterinary Pharmacology and Therapeutics 28:5, pages 447-452.
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C. Rasetti-Escargueil & V. Grangé. (2005) Pharmacokinetic profiles of two tablet formulations of piroxicam. International Journal of Pharmaceutics 295:1-2, pages 129-134.
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H. L. Heeb, R. Chun, D. E. Koch, M. A. Goatley & R. P. Hunter. (2003) Single dose pharmacokinetics of piroxicam in cats. Journal of Veterinary Pharmacology and Therapeutics 26:4, pages 259-263.
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Alaa S Amin. (2002) Spectrophotometric determination of piroxicam and tenoxicam in pharmaceutical formulations using alizarin. Journal of Pharmaceutical and Biomedical Analysis 29:4, pages 729-736.
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S.A Al-Tamrah. (1998) Flow injection spectrophotometric determination of tenoxicam. Analytica Chimica Acta 375:3, pages 277-283.
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Aziz Karim, Robert Noveck, F. Gilbert McMahon, Margo Smith, Sharon Crosby, Marijke Adams & John Wilton. (2013) Oxaprozin and Piroxicam, Nonsteroidal Antiinflammatory Drugs with Long Half‐Lives: Effect of Protein‐Binding Differences on Steady‐State Pharmacokinetics. The Journal of Clinical Pharmacology 37:4, pages 267-278.
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Roberto Maffei Facino, Marina Carini & Luisella Saibene. (2006) Scavenging of Free Radicals by Tenoxicam: A Participating Mechanism in the Antirheumatic/Antiinflammatory Efficacy of the Drug. Archiv der Pharmazie 329:10, pages 457-463.
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M. Patoux-pibouin, B. Hirel, C. Chesne, E. Watier, j. Chevrant-breton & A. Guillouzo. (1995) Cytotoxicity testing of β-lactam antibiotics, non-steroidal anti-inflammatory drugs and sulfonamides in primary human keratinocyte cultures. Toxicology in Vitro 9:4, pages 493-497.
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Toshio Suwa, Hidetoshi Urano, Yasuro Shinohara & Jun Kokatsu. (1993) Simultaneous high-performance liquid chromatographic determination of lornoxicam and its 5′-hydroxy metabolite in human plasma using electrochemical detection. Journal of Chromatography B: Biomedical Sciences and Applications 617:1, pages 105-110.
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Ana Lucia T. O. Nascimento, Jorge A. Escobar & Giuseppe Cilento. (2008) THE PEROXIDATIVE METABOLISM OF TENOXICAM PRODUCES EXCITED SPECIES. Photochemistry and Photobiology 57:2, pages 362-366.
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DIANA METODIEWA & H. BRIAN DUNFORD. 1993. Atmospheric Oxidation and Antioxidants. Atmospheric Oxidation and Antioxidants 287 332 .
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T. F. Woolf, A. Black, A. Sedman & T. Chang. (1992) Metabolic disposition of the non-steroidal anti-inflammatory agent isoxicam in man. European Journal of Drug Metabolism and Pharmacokinetics 17:1, pages 21-27.
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