33
Views
80
CrossRef citations to date
0
Altmetric
Research Article

Neoantigens Associated with Halothane Hepatitis

, , , &
Pages 203-217 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Cynthia Ju & Timothy Reilly. (2012) Role of immune reactions in drug-induced liver injury (DILI). Drug Metabolism Reviews 44:1, pages 107-115.
Read now
Dolores B Njoku. (2010) Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a review. Expert Opinion on Drug Metabolism & Toxicology 6:5, pages 519-531.
Read now
E. Stephanova, R. Valtcheva-Sarker, T. Topouzova-Hristova & Z. Lalchev. (2007) Influence of Volatile Anaesthetics on Lung Cells and Lung Surfactant. Biotechnology & Biotechnological Equipment 21:4, pages 393-398.
Read now
Yasuhiro Masubuchi & Toshiharu Horie. (2007) Toxicological Significance of Mechanism-Based Inactivation of Cytochrome P450 Enzymes by Drugs. Critical Reviews in Toxicology 37:5, pages 389-412.
Read now
Kenneth L. Hastings, Cynthia Thomas, Alan P. Brown & A. Jay Gandolfi. (1995) Trifluoroacetylation Potentiates the Humoral Immune Response to Halothane in the Guinea PIG. Immunopharmacology and Immunotoxicology 17:1, pages 201-213.
Read now
B. Kevin Park & Neil R. Kitteringham. (1994) Effects of Fluorine Substitution on Drug Metabolism: Pharmacological and Toxicological Implications. Drug Metabolism Reviews 26:3, pages 605-643.
Read now

Articles from other publishers (72)

David E. Kleiner. 2024. MacSween's Pathology of the Liver. MacSween's Pathology of the Liver 726 841 .
Wenhui Liu, Xiangchang Zeng, Yating Liu, Jinfeng Liu, Chaopeng Li, Lulu Chen, Hongying Chen & Dongsheng Ouyang. (2021) The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury. Frontiers in Pharmacology 12.
Crossref
Donald J. AbrahamDeepak K. Dalvie & Bernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 139 .
Nevena Todorović Vukotić, Jelena Đorđević, Snežana Pejić, Neda Đorđević & Snežana B. Pajović. (2021) Antidepressants- and antipsychotics-induced hepatotoxicity. Archives of Toxicology 95:3, pages 767-789.
Crossref
Benjamin M. Johnson, Yue-Zhong Shu, Xiaoliang Zhuo & Nicholas A. Meanwell. (2020) Metabolic and Pharmaceutical Aspects of Fluorinated Compounds. Journal of Medicinal Chemistry 63:12, pages 6315-6386.
Crossref
Albert J Czaja. (2019) Examining pathogenic concepts of autoimmune hepatitis for cues to future investigations and interventions. World Journal of Gastroenterology 25:45, pages 6579-6606.
Crossref
Benjamin L. Woolbright & Hartmut Jaeschke. (2018) Mechanisms of Inflammatory Liver Injury and Drug-Induced Hepatotoxicity. Current Pharmacology Reports 4:5, pages 346-357.
Crossref
Urs Christen & Edith Hintermann. (2018) Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease?. Frontiers in Immunology 9.
Crossref
David E. Kleiner. 2018. Macsween's Pathology of the Liver. Macsween's Pathology of the Liver 673 779 .
Anne-Christine Macherey & Patrick M. Dansette. 2015. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 585 614 .
Imir G. Metushi, Corron Sanders, William M. Lee & Jack Uetrecht. (2014) Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure. Hepatology 59:3, pages 1084-1093.
Crossref
Qiang You, Linling Cheng & Cynthia Ju. (2010) Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicology Letters 194:3, pages 79-85.
Crossref
Michael Holt & Cynthia Ju. 2010. Adverse Drug Reactions. Adverse Drug Reactions 3 27 .
Dolores B. Njoku, Zhaoxia Li, Nicole D. Washington, Jenelle L. Mellerson, Monica V. Talor, Rajni Sharma & Noel R. Rose. (2009) Suppressive and pro‐inflammatory roles for IL‐4 in the pathogenesis of experimental drug‐induced liver injury. European Journal of Immunology 39:6, pages 1652-1663.
Crossref
E. Stephanova, T. Topouzova-Hristova, R. Hazarosova & V. Moskova. (2008) Halothane-induced alterations in cellular structure and proliferation of A549 cells. Tissue and Cell 40:6, pages 397-404.
Crossref
John A. Timbrell. 2008. Principles of Biochemical Toxicology. Principles of Biochemical Toxicology 139 202 .
Christine Nguyen, Noel R Rose & Dolores B Njoku. (2008) Trifluoroacetylated IgG4 Antibodies in a Child With Idiosyncratic Acute Liver Failure After First Exposure to Halothane. Journal of Pediatric Gastroenterology & Nutrition 47:2, pages 199-202.
Crossref
Anne-Christine Macherey & Patrick M. Dansette. 2008. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 674 696 .
W.F. Trager. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 87 132 .
Frank N. A. M. van Pelt, Michelle A. Carey & John B. Carey. 2007. Liver Immunology. Liver Immunology 375 388 .
M.W. Anders. (2005) FORMATION AND TOXICITY OF ANESTHETIC DEGRADATION PRODUCTS. Annual Review of Pharmacology and Toxicology 45:1, pages 147-176.
Crossref
Rhonda S. Kaetzel, Martha D. Stapels, Douglas F. Barofsky & Donald J. Reed. (2004) Alkylation of protein disulfide isomerase by the episulfonium ion derived from the glutathione conjugate of 1,2-dichloroethane and mass spectrometric characterization of the adducts. Archives of Biochemistry and Biophysics 423:1, pages 136-147.
Crossref
Ralitza Valtcheva, Elena Stephanova, Albena Jordanova, Roumen Pankov, George Altankov & Zdravko Lalchev. (2003) Effect of halothane on lung carcinoma cells A 549. Chemico-Biological Interactions 146:2, pages 191-200.
Crossref
D. K. Spracklin, M. E. Emery, K. E. Thummel & E. D. Kharasch. (2003) Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. Acta Anaesthesiologica Scandinavica 47:6, pages 765-770.
Crossref
Anne-Christine Macherey & Patrick M. Dansette. 2003. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 545 560 .
Dean J. Naisbitt, Munir Pirmohamed & B. Kevin Park. (2003) Immunopharmacology of hypersensitivity reactions to drugs. Current Allergy and Asthma Reports 3:1, pages 22-29.
Crossref
Michael W. Lamé, A. Daniel Jones, Dennis W. Wilson, Sheryl K. Dunston & H.J. Segall. (2000) Protein Targets of Monocrotaline Pyrrole in Pulmonary Artery Endothelial Cells. Journal of Biological Chemistry 275:37, pages 29091-29099.
Crossref
H. Denk, H. P. Dienes, J. Düllmann, H.-P. Fischer, O. Klinge, W. Lierse, K.-H. Meyer zum Büschenfelde, U. Pfeifer, K. H. Preisegger, G. Ramadori, A. Tannapfel, Ch. Wittekind, U. Wulfhekel & H. ZhouO. Klinge. 2000. Pathologie der Leber und Gallenwege. Pathologie der Leber und Gallenwege 612 699 .
Geoffrey M. Thiele, Dean J. Tuma & Lynell W. Klassen. 1999. Autoimmune Reactions. Autoimmune Reactions 321 345 .
Doris B. Strader & Leonard B. Seeff. (1998) DRUG-INDUCED CHRONIC LIVER DISEASE. Clinics in Liver Disease 2:3, pages 501-522.
Crossref
A Guillouzo. (1998) Liver cell models in in vitro toxicology.. Environmental Health Perspectives 106:suppl 2, pages 511-532.
Crossref
Josef Gut. 1998. Diversification in Toxicology — Man and Environment. Diversification in Toxicology — Man and Environment 3 17 .
Dennis E. Feierman & Zoya Melnikov. (1997) Cytochrome P-4502E1-Dependent Formation of Trifluoroacetyl Adducts from Halothane by Transduced HepG2 Cells. Alcoholism: Clinical and Experimental Research 21:9, pages 1606-1611.
Crossref
Edmond I Eger, Pompiliu Ionescu, Michael J. Laster, Diane Gong, Richard B. Weiskopf & Russell L. Kerschmann. (1997) Quantitative Differences in the Production and Toxicity of CF2=BrCl Versus CH2 F-O-C(=CF2)(CF3) (Compound A). Anesthesia & Analgesia 85:5, pages 1164-1170.
Crossref
Sylvia M. Furst, Dennis Luedke, Htoo-Htoo Gaw, Richard Reich & A.Jay Gandolfi. (1997) Demonstration of a Cellular Immune Response in Halothane-Exposed Guinea Pigs. Toxicology and Applied Pharmacology 143:2, pages 245-255.
Crossref
Steven D. Cohen, Neil R. Pumford, Edward A. Khairallah, Kim Boekelheide, Lance R. Pohl, H.R. Amouzadeh & Jack A. Hinson. (1997) Selective Protein Covalent Binding and Target Organ Toxicity. Toxicology and Applied Pharmacology 143:1, pages 1-12.
Crossref
Dolores Njoku, Michael J. Laster, Diane H. Gong, Edmond I Eger, George F. Reed & Jackie L. Martin. (1997) Biotransformation of Halothane, Enflurane, Isoflurane, and Desflurane to Trifluoroacetylated Liver Proteins. Anesthesia & Analgesia 84:1, pages 173-178.
Crossref
N. El. Mikatti & T. E. J. Healy. (1997) Hepatic injury associated with halogenated anaesthetics: cross-sensitization and its clinical implications. European Journal of Anaesthesiology 14:1, pages 7-14.
Crossref
L.R. Pohl, N.R. Pumford & J.L. Martin. (2009) Mechanisms, chemical structures and drug metabolism. European Journal of Haematology 57:S60, pages 98-104.
Crossref
M. J. GÓMEZ-LECHÓN, J. CARRASQUER, J. BERENGUER & J. V. CASTELL. (1996) Evidence of antibodies to erythromycin in serum of a patient following an episode of acute drug-induced hepatitis. Clinical & Experimental Allergy 26:5, pages 590-596.
Crossref
E.D. Kharasch, D. Hankins, D. Mautz, E.D. Kharasch & K.E. Thummel. (1996) Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. The Lancet 347:9012, pages 1367-1371.
Crossref
M. Pirmohamed & B. K. Park. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 411 440 .
I. R. MacKay. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 221 247 .
Jackie L. Martin, David J. Plevak, Kathleen D. Flannery, Michael Charlton, John J. Poterucha, Chris E. Humphreys, Gregory Derfus & Lance R. Pohl. (1995) Hepatotoxicity after Desflurane Anesthesia. Anesthesiology 83:5, pages 1125-1129.
Crossref
Philippe Podevin & Michel Biour. (1995) Drug-induced “Allergic hepatitis”. Clinical Reviews in Allergy and Immunology 13:3, pages 223-244.
Crossref
Hamid R. Amouzadeh & Lance R. Pohl. (1995) Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes. Hepatology 22:3, pages 936-943.
Crossref
Josef Gut, Urs Christen, Nora Frey, Valeria Koch & Daniel Stoffler. (1995) Molecular mimicry in halothane hepatitis: Biochemical and structural characterization of lipoylated autoantigens. Toxicology 97:1-3, pages 199-224.
Crossref
B.Kevin Park, Munir Pirmohamed & Neil R. Kitteringham. (1995) The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacology & Therapeutics 68:3, pages 385-424.
Crossref
Urs CHRISTEN, Janet QUINN, Stephen J. YEAMAN, J. Gerald KENNA, Janet B. CLARKE, A. Jay GANDOLFI & Josef GUT. (1994) Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid. European Journal of Biochemistry 223:3, pages 1035-1047.
Crossref
Gennady P. Ilyin, Maryvonne Rissel, Yannick Malledant, Michèle Tanguy & André Guillouzo. (1994) Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane. Biochemical Pharmacology 48:3, pages 561-567.
Crossref
Frank N.A.M. Van Pelt & J.Gerald Kenna. (1994) Formation of trifluoroacetylated protein antigens in cultured rat hepatocytes exposed to halothane in vitro. Biochemical Pharmacology 48:3, pages 461-471.
Crossref
Jackie L. Martin, J. Gerald Kenna, Brian M. Martin, David Thomassen, George F. Reed & Lance R. Pohl. (1993) Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase. Hepatology 18:4, pages 858-863.
Crossref
Dorothy L. Gauggel, Katherine Sarlo & Thomas N. Asquith. (2006) A proposed screen for evaluating low‐molecular‐weight chemicals as potential respiratory allergens. Journal of Applied Toxicology 13:5, pages 307-313.
Crossref
Renee C. Lin, Samin Shahidi & Lawrence Lumeng. (2006) Production of Antibodies That Recognize the Heterogeneity of Immunoreactive Sites in Human Hemoglobin Chemically Modified by Acetaldehyde. Alcoholism: Clinical and Experimental Research 17:4, pages 882-886.
Crossref
F.N.A.M. van Pelt, T.L. Knight & J.G. Kenna. (1993) Generation of trifluoroacetylated protein antigens in cultured rat hepatocytes exposed to halothane in vitro. Toxicology in Vitro 7:4, pages 311-315.
Crossref
Urs Christen, Paul Jenoe & Josef Gut. (2002) Halothane metabolism: The dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts. Biochemistry 32:6, pages 1492-1499.
Crossref
Josef Gut, Urs Christen & Jörg Huwyler. (1993) Mechanisms of halothane toxicity: Novel insights. Pharmacology & Therapeutics 58:2, pages 133-155.
Crossref
Josef GUT, Urs CHRISTEN, Jörg HUWYLER, Maria BÜRGIN & J. Gerald KENNA. (2005) Molecular mimicry of trifluoroacetylated human liver protein adducts by consitutive proteins and immunochemical evidence for its impairment in halothane hepatitis. European Journal of Biochemistry 210:2, pages 569-576.
Crossref
BK Park, M. Pirmohamed & NR Kitteringham. (2012) Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.. British Journal of Clinical Pharmacology 34:5, pages 377-395.
Crossref
Jörg HUWYLER, Daniel AESCHLIMANN, Urs CHRISTEN & Josef GUT. (2005) The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2‐dichloro‐1,1,1‐trifluoroethane. European Journal of Biochemistry 207:1, pages 229-238.
Crossref
Jörg Huwyler & Josef Gut. (1992) Exposure to the chlorofluorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart. Biochemical and Biophysical Research Communications 184:3, pages 1344-1349.
Crossref
Alan P. Brown, Kenneth L. Hastings, A.Jay Gandolfi, Daniel C. Liebler & Klaus Brendel. (1992) Formation and identification of protein adducts to cytosolic proteins in guinea pig liver slices exposed to halothane. Toxicology 73:3, pages 281-295.
Crossref
D. Pessayre. 1992. Hepatobiliary Diseases. Hepatobiliary Diseases 697 727 .
P.J. Hayden, T. Ichimura, D.J. McCann, L.R. Pohl & J.L. Stevens. (1991) Detection of cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts.. Journal of Biological Chemistry 266:28, pages 18415-18418.
Crossref
Richard A. Willson. (1991) The Liver. Immunology and Allergy Clinics of North America 11:3, pages 555-574.
Crossref
Patrick J. Hayden, Yun Yang, Anthony J. I. Ward, Deanne M. Dulik, Denis J. McCann & James L. Stevens. (2002) Formation of difluorothionoacetyl-protein adducts by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine metabolites: nucleophilic catalysis of stable lysyl adduct formation by histidine and tyrosine. Biochemistry 30:24, pages 5935-5943.
Crossref
Paul B. Watkins. (1991) Antimicrosomal antibodies: What are they telling us?. Hepatology 13:2, pages 385-387.
Crossref
Mark A. Sanner & Terry J. Higgins. 1991. 181 190 .
Alan P. Brown, Kenneth L. Hastings & A.Jay Gandolfi. (1991) Generation and detection of neoantigens in guinea pig lever slices incubated with halothane. International Journal of Immunopharmacology 13:4, pages 429-435.
Crossref
Lance R. Pohl, David Thomassen, Neil R. Pumford, Lynn E. Butler, Hiroko Satoh, Victor J. Ferrans, Andrea Perrone, Brian M. Martin & Jackie L. Martin. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 111 120 .
J.G. Kenna, J.L. Martin & L.R. Pohl. (1990) Purification of trifluoroacetylated protein antigens from livers of halo thane-treated rats. European Journal of Pharmacology 183:4, pages 1139-1140.
Crossref
D. Thomassen, B.M. Martin, J.L. Martin, N.R. Pumford & L.R. Pohl. (1990) The role off a stress protein in the development off a drug-induced allergic response. European Journal of Pharmacology 183:4, pages 1138-1139.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.