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Research Article

Drug Metabolism and Toxicity During Hypoxia

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Pages 247-260 | Published online: 22 Sep 2008

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Victor Tseng, Scott Collum, Ayed Allawzi, Kathryn Crotty, Samantha Yeligar, Aaron Trammell, M. Ryan Smith, Bum-Yong Kang, Roy L. Sutliff, Jennifer L. Ingram, Soma SK Jyothula, Rajarajan A. Thandavarayan, Howard J. Huang, Eva S. Nozik, Eric J Wagner, C. Michael Hart & Harry Karmouty-Quintana. (2022) 3’UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension. Matrix Biology.
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Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La & Xiangyang Li. (2022) Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia. Drug Metabolism and Disposition 50:2, pages 174-186.
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M.M. Granados, C. Mengual, R. Navarrete-Calvo, J.A. Fernández-Sarmiento, J. Morgaz, S. Quirós-Carmona, J.M. Domínguez, A. Lora & Juan Manuel Serrano-Rodríguez. (2021) Influence of general anaesthesia on the intravenous acetaminophen pharmacokinetics in Beagle dogs. Veterinary Anaesthesia and Analgesia 48:5, pages 637-644.
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Hamed Kharrati-Koopaee, Esmaeil Ebrahimie, Mohammad Dadpasand, Ali Niazi, Rugang Tian & Ali Esmailizadeh. (2021) Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model. Journal of Genetic Engineering and Biotechnology 19:1.
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Iiro Kiiski, Päivi Järvinen, Elisa Ollikainen, Ville Jokinen & Tiina Sikanen. (2021) The material-enabled oxygen control in thiol-ene microfluidic channels and its feasibility for subcellular drug metabolism assays under hypoxia in vitro . Lab on a Chip 21:9, pages 1820-1831.
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Xiang-Yang Li, Ning Qu, Xue-Jun Wang, Jian-Xin Yang, Yuan-Yao Xin, Jun-Bo Zhu, Xue Bai & Ya-Bin Duan. (2020) Regulation of X-Ray Irradiation on the Activity and Expression Levels of CYP1A2 and CYP2E1 in Rats. Frontiers in Pharmacology 10.
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Xiangyang LiXuejun WangYongping LiJunbo ZhuXiaodong SuXingchen YaoXueru FanYabin Duan. (2014) The Activity, Protein, and mRNA Expression of CYP2E1 and CYP3A1 in Rats after Exposure to Acute and Chronic High Altitude Hypoxia. High Altitude Medicine & Biology 15:4, pages 491-496.
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Xiangyang Li, Xuejun Wang, Yongping Li, Ming Yuan, Junbo Zhu, Xiaodong Su, Xingchen Yao, Xueru Fan & Yabin Duan. (2014) Effect of Exposure to Acute and Chronic High-Altitude Hypoxia on the Activity and Expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in Rats. Pharmacology 93:1-2, pages 76-83.
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Shefali Gola, Gaurav Km. Keshri & Asheesh Gupta. (2013) Hepatic metabolism of ibuprofen in rats under acute hypobaric hypoxia. Experimental and Toxicologic Pathology 65:6, pages 751-758.
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S. Buhari, H. Kalthum, Y.M. Goh & S.H. Gan. (2013) Influence of Surgery on the Pharmacokinetics of Tramadol Following Intravenous Administration in Dogs. Asian Journal of Animal and Veterinary Advances 8:3, pages 483-492.
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Katie H. Owens, Natalie J. Medlicott, Mathew Zacharias, Neil Curran, Sree Chary, Mark Thompson-Fawcett & David M. Reith. (2012) The Pharmacokinetic Profile of Intravenous Paracetamol in Adult Patients Undergoing Major Abdominal Surgery. Therapeutic Drug Monitoring 34:6, pages 713-721.
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Ya-bin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La & Xiangyang Li. (2021) Exposure to High Altitude Environment Is Associated With Drug Metabolism Change: miRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters Under Hypoxia. SSRN Electronic Journal.
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