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Research Article

Degradation of Rat Hepatic Cytochrome P-450p

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Pages 615-628 | Published online: 22 Sep 2008

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Read on this site (2)

Maria Almira Correia & Mingxiang Liao. (2007) Cellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomyces cerevisiae to mammalian liver. Expert Opinion on Drug Metabolism & Toxicology 3:1, pages 33-49.
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Maria Almira Correia. (2003) Hepatic Cytochrome P450 Degradation: Mechanistic Diversity of the Cellular Sanitation Brigade. Drug Metabolism Reviews 35:2-3, pages 107-143.
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Articles from other publishers (18)

Mingxiang Liao, Ping Kang, Bernard P. Murray & Maria Almira Correia. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 363 406 .
YongQiang Wang, Mingxiang Liao, Nicholas Hoe, Poulomi Acharya, Changhui Deng, Andrew N. Krutchinsky & Maria Almira Correia. (2009) A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation. Journal of Biological Chemistry 284:9, pages 5671-5684.
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Saadia Faouzi, Katalin F. Medzihradszky, Colleen Hefner, Jacquelyn J. Maher & Maria Almira Correia. (2007) Characterization of the Physiological Turnover of Native and Inactivated Cytochromes P450 3A in Cultured Rat Hepatocytes:  A Role for the Cytosolic AAA ATPase p97?. Biochemistry 46:26, pages 7793-7803.
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Maria Almira Correia & Paul R. Ortiz de Montellano. 2005. Cytochrome P450. Cytochrome P450 247 322 .
Bernard P. Murray & Maria Almira Correia. (2001) Ubiquitin-Dependent 26S Proteasomal Pathway: A Role in the Degradation of Native Human Liver CYP3A4 Expressed in Saccharomyces Cerevisiae?. Archives of Biochemistry and Biophysics 393:1, pages 106-116.
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Raymond F. Novak & Kimberley J. Woodcroft. (2000) The alcohol-inducible form of cytochrome P450 (CYP2E1): Role in toxicology and regulation of expression. Archives of Pharmacal Research 23:4, pages 267-282.
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Huifen Faye Wang, Maria-Emilia Figueiredo Pereira & Maria Almira Correia. (1999) Cytochrome P450 3A Degradation in Isolated Rat Hepatocytes: 26S Proteasome Inhibitors as Probes. Archives of Biochemistry and Biophysics 365:1, pages 45-53.
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Katy Kuo Korsmeyer, Suzanne Davoll, Maria Emilia Figueiredo-Pereira & Maria Almira Correia. (1999) Proteolytic Degradation of Heme-Modified Hepatic Cytochromes P450: A Role for Phosphorylation, Ubiquitination, and the 26S Proteasome?. Archives of Biochemistry and Biophysics 365:1, pages 31-44.
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Francesco De Matteis & Gerald S Marks. (1996) Cytochrome P450 and its interactions with the heme biosynthetic pathway. Canadian Journal of Physiology and Pharmacology 74:1, pages 1-8.
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Susan M Kimmett, James P McNamee & Gerald S Marks. (1996) Chick embryo liver microsomal steroid hydroxylations: induction by dexamethasone, phenobarbital, and glutethimide and inactivation following the in ovo administration of porphyrinogenic compounds. Canadian Journal of Physiology and Pharmacology 74:1, pages 97-103.
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James P. McNamee, Susan M. Kimmett & Gerald S. Marks. (1995) Inactivation of chick embryo hepatic cytochrome P450 1A, 2H and 3A following in ovo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine and 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone. Biochemical Pharmacology 49:10, pages 1443-1452.
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K. Yao, A.M. Falick, N. Patel & M.A. Correia. (1993) Cumene hydroperoxide-mediated inactivation of cytochrome P450 2B1. Identification of an active site heme-modified peptide.. Journal of Biological Chemistry 268:1, pages 59-65.
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Maria Almira Correia, Suzanne H. Davoll, Steven A. Wrighton & Paul E. Thomas. (1992) Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: Characterization of the proteolytic system. Archives of Biochemistry and Biophysics 297:2, pages 228-238.
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Maria Almira Correia, Kunquan Yao, Steven A. Wrighton, David J. Waxman & Allan E. Rettie. (1992) Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: A case for distinct proteolytic mechanisms?. Archives of Biochemistry and Biophysics 294:2, pages 493-503.
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Vera Ribeiro & Maria Celeste Lechner. (1992) Cloning and characterization of a novel CYP3A1 allelic variant: Analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone. Archives of Biochemistry and Biophysics 293:1, pages 147-152.
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Y.S. Choe & P.R. Ortiz de Montellano. (1991) Differential additions to the myoglobin prosthetic heme group. Oxidative gamma-meso substitution by alkylhydrazines. Journal of Biological Chemistry 266:13, pages 8523-8530.
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Dennis R. Koop & Daniel J. Tierney. (2005) Multiple mechanisms in the regulation of ethanol‐inducible cytochrome P450IIE1. BioEssays 12:9, pages 429-435.
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Paul R. Ortiz de Montellano. (1990) Free radical modification of prosthetic heme groups. Pharmacology & Therapeutics 48:1, pages 95-120.
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