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Drug Metabolism Reviews Volume 22, 1990 - Issue 6-8
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Research Article

In Vivo and in Vitro Metabolic Studies of Furazolidone: A Risk Evaluation

Louis H. M. Vroomen State Institute for Quality Control of Agricultural Products (RIKILT), Department of Toxicology, P.O. Box 230, 6700, AE, Wageningen, The Netherlands
,
Marcel C. J. Berghmans State Institute for Quality Control of Agricultural Products (RIKILT), Department of Toxicology, P.O. Box 230, 6700, AE, Wageningen, The Netherlands
,
Peter J. Van Bladeren Agricultural University, Department of Toxicology De Dreijen 12, 6703, BC, Wageningen, The Netherlands
,
John P. Groten Agricultural University, Department of Toxicology De Dreijen 12, 6703, BC, Wageningen, The Netherlands
,
C. J. Wissink Agricultural University, Department of Toxicology De Dreijen 12, 6703, BC, Wageningen, The Netherlands
&
Harry A. Kuiper State Institute for Quality Control of Agricultural Products (RIKILT), Department of Toxicology, P.O. Box 230, 6700, AE, Wageningen, The Netherlands
Pages 663-676 | Published online: 22 Sep 2008

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Fengyin Liu, Zijian Chen, Yudong Shen, Yuanming Sun, Jinyi Yang, Hong Wang, Hongtao Lei & Zhenlin Xu. (2018) Hapten synthesis and production of specific antibody against 3-amino-5-morpholinomethyl-2-oxazolidone for immunoassay without derivatisation. Food and Agricultural Immunology 29:1, pages 332-345.
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D. M. Galer & A. M. Monro. (1998) Evaluation of the toxicity of drug residues in food: The case for ‘relay’ toxicity studies. Food Additives & Contaminants 15:4, pages 494-500.
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RobertJ. McCracken & D. Glenn Kennedy. (1997) The bioavailability of residues of the furazolidone metabolite 3‐amino‐2‐oxazolidinone in porcine tissues and the effect of cooking upon residue concentrations. Food Additives & Contaminants 14:5, pages 507-513.
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F. C. P. Law & J. Meng. (1996) Binding of 14C‐furazolidone metabolites to the muscular and hepatic proteins of trout∗ . Food Additives & Contaminants 13:2, pages 199-209.
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S. M. Plakas, K. R. El Said & G. R. Stehly. (1994) Furazolidone disposition after intravascular and oral dosing in the channel catfish. Xenobiotica 24:11, pages 1095-1105.
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Articles from other publishers (22)

Gemma Regan, Christopher Elliott & Martin Danaher. 2024. Encyclopedia of Food Safety. Encyclopedia of Food Safety 461 469 .
Gemma Regan, Mary Moloney, Melissa Di Rocco, Padraig McLoughlin, Wesley Smyth, Steven Crooks, Christopher Elliott & Martin Danaher. (2021) Development and validation of a rapid LC–MS/MS method for the confirmatory analysis of the bound residues of eight nitrofuran drugs in meat using microwave reaction. Analytical and Bioanalytical Chemistry 414:3, pages 1375-1388.
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Michael O'Keeffe, Anna Christodoulidou & Carlo Nebbia. (2021) Presence of nitrofurans and their metabolites in gelatine. EFSA Journal 19:10.
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Mikyoung Lee, In-Seok Lee, Minkyu Choi & Wonchan Lee. (2020) Simultaneous Analysis of four Nitrofurans and Chloramphenicol Antibiotics in Seawater and Fisheries water using LC-MS/MS. Journal of Environmental Analysis, Health and Toxicology 23:2, pages 81-89.
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A. V. Kulikovskii, I. F. Gorlov, M. I. Slozhenkina, N. L. Vostrikova, A. N. Ivankin & O. A. Kuznetsova. (2019) Determination of Nitrofuran Metabolites in Muscular Tissue by High-Performance Liquid Chromatography with Mass Spectrometric Detection. Journal of Analytical Chemistry 74:9, pages 906-912.
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Seung Taek Nam, Hyun Woo Kim, Hyuk Soon Kim, Young Hwan Park, Dajeong Lee, Min Bum Lee, Keun Young Min, Young Mi Kim & Wahn Soo Choi. (2018) Furaltadone suppresses IgE-mediated allergic response through the inhibition of Lyn/Syk pathway in mast cells. European Journal of Pharmacology 828, pages 119-125.
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. (2015) Scientific Opinion on nitrofurans and their metabolites in food. EFSA Journal 13:6.
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Zenaida Negrin, Yoslainy Valdés, Tania Pouron, Edell López & Keyller Borges. (2013) A novel 2-(2-methyl-2-nitrovinyl)-furan ectoparasitic drug: physicochemical characterization and determination of the raw material by gas chromatography mass spectrometry. Open Chemistry 11:4, pages 594-603.
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Kevin Woodward & Kevin WoodwardK. N. Woodward. 2012. Toxicological Effects of Veterinary Medicinal Products in Humans. Toxicological Effects of Veterinary Medicinal Products in Humans 273 380 .
Jorge Barbosa, Andreia Freitas, Sara Moura, José Luis Mourão, Maria Irene Noronha da Silveira & Fernando Ramos. (2011) Detection, Accumulation, Distribution, and Depletion of Furaltadone and Nifursol Residues in Poultry Muscle, Liver, and Gizzard. Journal of Agricultural and Food Chemistry 59:22, pages 11927-11934.
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Colin S. Thompson, Imelda M. Traynor, Terence L. Fodey, Steven R.H. Crooks & D. Glenn Kennedy. (2011) Screening method for the detection of a range of nitrofurans in avian eyes by optical biosensor. Analytica Chimica Acta 700:1-2, pages 177-182.
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K. N. Woodward. 2009. Veterinary Pharmacovigilance. Veterinary Pharmacovigilance 297 345 .
M. Vass, K. Hruska & M. Franek. (2008) Nitrofuran antibiotics: a review on the application, prohibition and residual analysis. Veterinární medicína 53:9, pages 469-500.
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Pak-Sin Chu, Mayda I. Lopez, Ann Abraham, Kathleen R. El Said & Steven M. Plakas. (2008) Residue Depletion of Nitrofuran Drugs and Their Tissue-Bound Metabolites in Channel Catfish ( Ictalurus punctatus ) after Oral Dosing . Journal of Agricultural and Food Chemistry 56:17, pages 8030-8034.
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Hanaa H. Ahmed, Sekena H. Abd El-Aziem & Mosaad A. Abdel-Wahhab. (2008) Potential role of cysteine and methionine in the protection against hormonal imbalance and mutagenicity induced by furazolidone in female rats. Toxicology 243:1-2, pages 31-42.
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M. Franek, I. Diblikova, M. Vass, L. Kotkova, K. Stastny, K. Frgalova & K. Hruska. (2006) Validation of a monoclonal antibody-based ELISA for the quantification of the furazolidone metabolite (AOZ) in eggs using various sample preparation. Veterinární medicína 51:5, pages 248-257.
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K.N. Woodward. 2004. Pesticide, Veterinary and Other Residues in Food. Pesticide, Veterinary and Other Residues in Food 175 223 .
Laurentius A.P Hoogenboom, Gerard D van Bruchem, Kim Sonne, Ilona C Enninga, Johannes A van Rhijn, Henri Heskamp, Margot B.M Huveneers-Oorsprong, Jan C.M van der Hoeven & Harry A Kuiper. (2002) Absorption of a mutagenic metabolite released from protein-bound residues of furazolidone. Environmental Toxicology and Pharmacology 11:3-4, pages 273-287.
Crossref
J. Meng, S.S. Mangat, I.P. Grudzinski & F.C.P. Law. (1998) Evidence of 14C-Furazolidone Metabolite Binding to the Hepatic DNA of Trout. Drug Metabolism and Drug Interactions 14:4.
Crossref
Thomas A. Baillie & Kelem Kassahun. 1994. 163 181 .
Guy R. Stehly & Steven M. Plakas. (1993) Pharmacokinetics, tissue distribution, and metabolism of nitrofurantoin in the channel catfish (Ictalurus punctatus). Aquaculture 113:1-2, pages 1-10.
Crossref
L.A.P. Hoogenboom, M. van Kammen, M.B.M. Huveneers-Oorsprong & H.A. Kuiper. (1992) Study on the role of glutathione in the biotransformation and toxicity of furazolidone using pig hepatocytes. Toxicology in Vitro 6:3, pages 227-237.
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