Citations (78)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (4)
Nicole C. Rouse & Howard I. Maibach. (2016) The effect of volatility on percutaneous absorption. Journal of Dermatological Treatment 27:1, pages 5-10.
Read now
Read now
David R Staskin & Dudley Robinson. (2009) Oxybutynin chloride topical gel: a new formulation of an established antimuscarinic therapy for overactive bladder. Expert Opinion on Pharmacotherapy 10:18, pages 3103-3111.
Read now
Read now
G. L. Qiao & J. E. Riviere. (2002) SYSTEMIC UPTAKE AND CUTANEOUS DISPOSITION OF PENTACHLOROPHENOL IN A SEQUENTIAL EXPOSURE SCENARIO: EFFECTS OF SKIN PREEXPOSURE TO BENZO[a]PYRENE. Journal of Toxicology and Environmental Health, Part A 65:18, pages 1307-1331.
Read now
Read now
Jim E. Riviere & Nancy A. Monteiro-Riviere. (1991) The Isolated Perfused Porcine Skin Flap as anIn Vitro Model for Percutaneous Absorption and Cutaneous Toxicology. Critical Reviews in Toxicology 21:5, pages 329-344.
Read now
Read now
Articles from other publishers (74)
Faith M Williams. (2023) New approaches build upon historical studies in dermal toxicology. Toxicology Research.
Crossref
Crossref
Akmal H. Sabri, Yujin Kim, Maria Marlow, David J. Scurr, Joel Segal, Ajay K. Banga, Leonid Kagan & Jong Bong Lee. (2020) Intradermal and transdermal drug delivery using microneedles – Fabrication, performance evaluation and application to lymphatic delivery. Advanced Drug Delivery Reviews 153, pages 195-215.
Crossref
Crossref
Sugibayashi Kenji. (2018) In Silico Estimation of Skin Concentration of Dermally Metabolized Chemicals. International Journal of Pharmaceutical Sciences and Developmental Research, pages 007-016.
Crossref
Crossref
Hiroaki Todo. (2017) Transdermal Permeation of Drugs in Various Animal Species. Pharmaceutics 9:4, pages 33.
Crossref
Crossref
Masahiro Sugino, Tomomi Hatanaka, Hiroaki Todo, Yuko Mashimo, Takamasa Suzuki, Miho Kobayashi, Osamu Hosoya, Hideto Jinno, Kazuhiko Juni & Kenji Sugibayashi. (2017) Safety evaluation of dermal exposure to phthalates: Metabolism-dependent percutaneous absorption. Toxicology and Applied Pharmacology 328, pages 10-17.
Crossref
Crossref
Tomomi Hatanaka. 2017. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds
67
76
.
C. Jacques, E. Perdu, E.L. Jamin, J.P. Cravedi, A. Mavon, H. Duplan & D. Zalko. (2014) Effect of Skin Metabolism on Dermal Delivery of Testosterone: Qualitative Assessment using a New Short-Term Skin Model. Skin Pharmacology and Physiology 27:4, pages 188-188.
Crossref
Crossref
Kenneth T. Bogen. (2013)
Dermal Uptake of 18 Dilute Aqueous Chemicals:
In Vivo
Disappearance-Method Measures Greatly Exceed
In Vitro
-Based Predictions
. Risk Analysis 33:7, pages 1334-1352.
Crossref
Crossref
Kelly Jirschele & Peter K. Sand. (2012) Oxybutynin: past, present, and future. International Urogynecology Journal 24:4, pages 595-604.
Crossref
Crossref
Mai A. Ngo, Michael O’Malley & Howard I. Maibach. 2013. Nanotechnology in Dermatology. Nanotechnology in Dermatology
63
86
.
Aurélie Berthet, Michèle Bouchard & David Vernez. (2011) Toxicokinetics of captan and folpet biomarkers in dermally exposed volunteers. Journal of Applied Toxicology 32:3, pages 202-209.
Crossref
Crossref
Mai A. Ngo & Howard I. Maibach. 2012. Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment
67
86
.
Barrie Finnin, Kenneth A. Walters & Thomas J. Franz. 2011. Topical and Transdermal Drug Delivery. Topical and Transdermal Drug Delivery
85
108
.
K A Lamb, S P Denyer, F D Sanderson & P N Shaw. (1994) The Metabolism of a Series of Ester Pro-drugs by NCTC 2544 Cells, Skin Homogenate and LDE Testskin. Journal of Pharmacy and Pharmacology 46:12, pages 965-973.
Crossref
Crossref
Doreen E. Chung. (2010) Topical Pharmacotherapy for Overactive Bladder. Current Bladder Dysfunction Reports 6:1, pages 20-24.
Crossref
Crossref
Hans Schaefer, Thomas E. Redelmeier & Jürgen Lademann. 2011. Contact Dermatitis. Contact Dermatitis
215
227
.
Carine Jacques, Elisabeth Perdu, Hélène Duplan, Emilien L. Jamin, Cécile Canlet, Laurent Debrauwer, Jean Pierre Cravedi, Alain Mavon & Daniel Zalko. (2010) Disposition and biotransformation of 14C-Benzo(a)pyrene in a pig ear skin model: Ex vivo and in vitro approaches. Toxicology Letters 199:1, pages 22-33.
Crossref
Crossref
Mai A. Ngo & Howard I. Maibach. (2010) Dermatotoxicology: Historical perspective and advances. Toxicology and Applied Pharmacology 243:2, pages 225-238.
Crossref
Crossref
Mai A. Ngo, Michael O'Malley & Howard I. Maibach. (2009) Percutaneous absorption and exposure assessment of pesticides. Journal of Applied Toxicology 30:2, pages 91-114.
Crossref
Crossref
A. Srivastava, J. L. Maggs, D. J. Antoine, D. P. Williams, D. A. Smith & B. K. Park. 2010. Adverse Drug Reactions. Adverse Drug Reactions
165
194
.
Rachel J. Walsh, Abhishek Srivastava, Daniel J. Antoine, Dominic P. Williams & B. Kevin Park. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions
651
664
.
Van Luu-The, Daniel Duche, Corinne Ferraris, Jean-Roch Meunier, Jacques Leclaire & Fernand Labrie. (2009) Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin? and full thickness model from Episkin?. The Journal of Steroid Biochemistry and Molecular Biology 116:3-5, pages 178-186.
Crossref
Crossref
Valentina Andreoni & Mario Giorgi. (2009) Evaluation of Plasma Detectable Concentrations of Two Lidocaine Transdermal Formulations and Their Analgesic Effect in the Horse. Journal of Equine Veterinary Science 29:9, pages 681-686.
Crossref
Crossref
John Timbrell. 2008. Principles of Biochemical Toxicology, Fourth Edition. Principles of Biochemical Toxicology, Fourth Edition
75
127
.
Matthew J. Traynor, Simon C. Wilkinson & Faith M. Williams. (2008) Metabolism of butoxyethanol in excised human skin in vitro. Toxicology Letters 177:3, pages 151-155.
Crossref
Crossref
P. C. Mills. (2006) Vehicle Effects on the In Vitro Penetration of Testosterone through Equine Skin. Veterinary Research Communications 31:2, pages 227-233.
Crossref
Crossref
Matthew J. Traynor, Simon C. Wilkinson & Faith M. Williams. (2007) The influence of water mixtures on the dermal absorption of glycol ethers. Toxicology and Applied Pharmacology 218:2, pages 128-134.
Crossref
Crossref
P.C. Mills & S.E. Cross. (2006) Transdermal drug delivery: Basic principles for the veterinarian. The Veterinary Journal 172:2, pages 218-233.
Crossref
Crossref
Hans Schaefer & Thomas E. Redelmeier. 2006. Contact Dermatitis. Contact Dermatitis
167
178
.
Paul C. Mills, Beatrice M. Magnusson & Sheree E. Cross. (2005) Penetration of a topically applied nonsteroidal anti-inflammatory drug into local tissues and synovial fluid of dogs. American Journal of Veterinary Research 66:7, pages 1128-1132.
Crossref
Crossref
David J. Lockley, Douglas Howes & Faith M. Williams. (2004) Percutaneous penetration and metabolism of 2-butoxyethanol. Archives of Toxicology 78:11, pages 617-628.
Crossref
Crossref
Elka Touitou, Biana Godin, Thirumala Kommuru, Mohsen Afouna & Indra Reddy. 2004. Chirality in Drug Design and Development. Chirality in Drug Design and Development.
N. Philips, D. Burchill, D. O’Donoghue, T. Keller & S. Gonzalez. (2004) Identification of Benzene Metabolites in Dermal Fibroblasts as Nonphenolic: Regulation of Cell Viability, Apoptosis, Lipid Peroxidation and Expression of Matrix Metalloproteinase 1 and Elastin by Benzene Metabolites. Skin Pharmacology and Physiology 17:3, pages 147-152.
Crossref
Crossref
Johanna T.H.M. van den Akker, J. Andrew Holroyd, David I. Vernon, Henricus J.C.M. Sterenborg & Stanley B. Brown. (2003) Comparative in vitro percutaneous penetration of 5‐aminolevulinic acid and two of its esters through excised hairless mouse skin. Lasers in Surgery and Medicine 33:3, pages 173-181.
Crossref
Crossref
Lilian G Yengi, Qian Xiang, Jinmei Pan, JoAnn Scatina, John Kao, Simon E Ball, Richard Fruncillo, Geraldine Ferron & C Roland Wolf. (2003) Quantitation of cytochrome P450 mRNA levels in human skin. Analytical Biochemistry 316:1, pages 103-110.
Crossref
Crossref
Osamu Ueda, Shigeyuki Kitamura, Koji Ohashi, Kazumi Sugihara & Shigeru Ohta. (2003) Xanthine Oxidase-Catalyzed Metabolism of 2-Nitrofluorene, a Carcinogenic Air Pollutant, in Rat Skin. Drug Metabolism and Disposition 31:4, pages 367-372.
Crossref
Crossref
Lene Simonsen, Mads B Petersen & Lotte Groth. (2002) In vivo skin penetration of salicylic compounds in hairless rats. European Journal of Pharmaceutical Sciences 17:1-2, pages 95-104.
Crossref
Crossref
Robert E. Kramer, Susan E. Wellman, Robin W. Rockhold & Rodney C. Baker. (2002) Pharmacokinetics of methyl parathion: A comparison following single intravenous, oral or dermal administration. Journal of Biomedical Science 9:4, pages 311-320.
Crossref
Crossref
David J. Lockley, Douglas Howes & Faith M. Williams. (2002) Percutaneous Penetration and Metabolism of 2-Ethoxyethanol. Toxicology and Applied Pharmacology 180:2, pages 74-82.
Crossref
Crossref
Adrian Davis & Christian Surber. 2002. Dermatological and Transdermal Formulations. Dermatological and Transdermal Formulations
396
493
.
. 2001. The Physiological Basis of Veterinary Clinical Pharmacology. The Physiological Basis of Veterinary Clinical Pharmacology
178
209
.
Hans Schaefer & Thomas E. Redelmeier. 2001. Textbook of Contact Dermatitis. Textbook of Contact Dermatitis
209
225
.
Timothy P. Reilly, Lawrence H. Lash, Mark A. Doll, David W. Hein, Patrick M. Woster & Craig K. Svensson. (2000) A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions. Journal of Investigative Dermatology 114:6, pages 1164-1173.
Crossref
Crossref
PETER BODERKE, KLAUS SCHITTKOWSKI, MANFRED WOLF & HANS P. MERKLE. (2000) Modeling of Diffusion and Concurrent Metabolism in Cutaneous Tissue. Journal of Theoretical Biology 204:3, pages 393-407.
Crossref
Crossref
Stephen DeVito. 2000. Handbook of Property Estimation Methods for Chemicals. Handbook of Property Estimation Methods for Chemicals.
Dean J. Naisbitt, Sfraser Gordon, Munir Pirmohamed & Bkevin Park. (2000) Immunological Principles of Adverse Drug Reactions. Drug Safety 23:6, pages 483-507.
Crossref
Crossref
Andreas Luch, Holger Friesel, Albrecht Seidel & Karl-Ludwig Platt. (1999) Tumor-initiating activity of the (+)-(S,S)- and (−)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin. Cancer Letters 136:2, pages 119-128.
Crossref
Crossref
P. M. Bos, D. H. Brouwer, H. Stevenson, P. J. Boogaard, W. L. de Kort & J. J. van Hemmen. (1998) Proposal for the assessment of quantitative dermal exposure limits in occupational environments: Part 1. Development of a concept to derive a quantitative dermal occupational exposure limit. Occupational and Environmental Medicine 55:12, pages 795-804.
Crossref
Crossref
Alka Singh & Yogeshwer Shukla. (1998) Antitumour activity of diallyl sulfide on polycyclic aromatic hydrocarbon-induced mouse skin carcinogenesis. Cancer Letters 131:2, pages 209-214.
Crossref
Crossref
Sheree E. CrossChris Anderson & Michael S. Roberts. (2002) Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies. British Journal of Clinical Pharmacology 46:1, pages 29-35.
Crossref
Crossref
Gabriele E Bast. (2016) Influence of solubility and permeant size on absorption and metabolism of xenobiotics in rabbit skin. Human & Experimental Toxicology 16:8, pages 435-440.
Crossref
Crossref
Senam A.J. Beckley-Kartey, Sharon A.M. Hotchkiss & Margred Capel. (1997) Comparativein VitroSkin Absorption and Metabolism of Coumarin (1,2-Benzopyrone) in Human, Rat, and Mouse. Toxicology and Applied Pharmacology 145:1, pages 34-42.
Crossref
Crossref
P. Nasseri-Sina, S.A.M. Hotchkiss & J. Caldwell. (1997) Cutaneous xenobiotic metabolism: glycine conjugation in human and rat keratinocytes. Food and Chemical Toxicology 35:3-4, pages 409-416.
Crossref
Crossref
Lori E. Shapiro & Neil H. Shear. (1996) Mechanisms of drug reactions: The metabolic track. Seminars in Cutaneous Medicine and Surgery 15:4, pages 217-227.
Crossref
Crossref
E Hodgson & P E Levi. (1996) Pesticides: an important but underused model for the environmental health sciences.. Environmental Health Perspectives 104:suppl 1, pages 97-106.
Crossref
Crossref
Klyoshi Kubota, John Ademola & Howard I. Maibach. (1995) Simultaneous Diffusion and Metabolism of Betamethasone 17-Valerate in the Living Skin Equivalent. Journal of Pharmaceutical Sciences 84:12, pages 1478-1481.
Crossref
Crossref
Inga Steinsträsser, René Sperb & Hans P. Merkle. (1995) Physical Model Relating Diffusional Transport and Concurrent Metabolism of Peptides in Metabolically Active Cell Sheets. Journal of Pharmaceutical Sciences 84:11, pages 1332-1341.
Crossref
Crossref
J.L. Garrigue, Ph. Catroux & J. Leclaire. (1995) Toxicologie prédictive moléculaire et génétique Application à la détection du pouvoir sensibilisant des molécules. Revue Française d'Allergologie et d'Immunologie Clinique 35:5, pages 455-461.
Crossref
Crossref
Jean-Luc Garrigue, Philippe Catroux & Jacques Leclaire. (1995) Predictive molecular and genetic toxicology. Clinical Reviews in Allergy and Immunology 13:3, pages 189-200.
Crossref
Crossref
Inga Steinsträsser & Hans P. Merkle. (1995) Dermal metabolism of topically applied drugs: Pathways and models reconsidered. Pharmaceutica Acta Helvetiae 70:1, pages 3-24.
Crossref
Crossref
G.L. Qiao & J.E. Riviere. (1995) Significant Effects of Application Site and Occlusion on the Pharmacokinetics of Cutaneous Penetration and Biotransformation of Parathion in Vivo in Swine. Journal of Pharmaceutical Sciences 84:4, pages 425-432.
Crossref
Crossref
B.B. Michniak, M.R. Player, D.A. Godwin, C.A. Phillips & J.W. Sowellsr.sr.. (1995) In vitro evaluation of a series of Azone analogs as dermal penetration enhancers: IV. Amines. International Journal of Pharmaceutics 116:2, pages 201-209.
Crossref
Crossref
B. Hirel, C. Chesne, J.P. Pailheret & A. Guillouzo. (1995) In Vitro expression of drug metabolizing enzyme activities in human adult keratinocytes under various culture conditions and their response to inducers. Toxicology in Vitro 9:1, pages 49-56.
Crossref
Crossref
F. VECCHINI, K. MACE, J. MAGDALOU, Y. MAHE, B.A. BERNARD & B. SHROOT. (1995) Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes. British Journal of Dermatology 132:1, pages 14-21.
Crossref
Crossref
Roger K. Verbeeck. 1995. Modulation of Cellular Responses in Toxicity. Modulation of Cellular Responses in Toxicity
125
144
.
B.B. Michniak, M.R. Player, J.M. ChapmanJr.Jr. & J.W. SowellSr.Sr.. (1994) Azone analogues as penetration enhancers: effect of different vehicles on hydrocortisone acetate skin permeation and retention. Journal of Controlled Release 32:2, pages 147-154.
Crossref
Crossref
B.B. Michniak, M.R. Player, L.C. Fuhrman, C.A. Christensen, J.M. ChapmanJrJr & J.W. SowellSrSr. (1994) In vitro evaluation of a series of azone analogs as dermal penetration enhancers: III. Acyclic amides. International Journal of Pharmaceutics 110:3, pages 231-239.
Crossref
Crossref
N. GYRD‐HANSEN, L. BRIMER & F. RASMUSSEN. (2008) Percutaneous absorption of organophosphorus insecticides in pigs – the influence of different vehicles. Journal of Veterinary Pharmacology and Therapeutics 16:2, pages 174-180.
Crossref
Crossref
Kiyoshi Kubota, Malgorzata Sznitowska & Howard I. Maibach. (1993) Percutaneous Absorption: A Single-Layer Model. Journal of Pharmaceutical Sciences 82:5, pages 450-456.
Crossref
Crossref
Bozena B. Mlchniak, James M. Chapman & Kazimierz L. Seyda. (1993) Facilitated Transport of Two Model Steroids by Esters and Amides of Clofibric Acid. Journal of Pharmaceutical Sciences 82:2, pages 214-219.
Crossref
Crossref
M.J. Seaton & E.S. Vesell. (1993) Variables affecting nicotine metabolism. Pharmacology & Therapeutics 60:3, pages 461-500.
Crossref
Crossref
Nicholas W. E. Clark, Robert C. Scott, Peter G. Blain & Faith M. Williams. (1993) Fate of fluazifop butyl in rat and human skin in vitro. Archives of Toxicology 67:1, pages 44-48.
Crossref
Crossref
Gabriela Nicolau & Avraham Yacobi. 1993. Topical Drug Bioavailability, Bioequivalence, and Penetration. Topical Drug Bioavailability, Bioequivalence, and Penetration
291
308
.
Krishnappa Venkatesh, Patricia E. Levi, Alfred O. Inman, Nancy A. Monteiro-Riviere, Rama Misra & Ernest Hodgson. (1992) Enzymatic and immunohistochemical studies on the role of cytochrome P450 and the flavin-containing monooxygenase of mouse skin in the metabolism of pesticides and other xenobiotics. Pesticide Biochemistry and Physiology 43:1, pages 53-66.
Crossref
Crossref