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Drug Metabolism Reviews Volume 24, 1992 - Issue 1
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Research Article

Models of Hepatic Drug Elimination

Bradley A. Saville Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
,
Murray R. Gray Department of Chemical Engineering, University of Alberta, Edmonton, Alberta, Canada
&
Yun K. Tam Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta, Edmonton, Alberta, Canada
Pages 49-88 | Published online: 22 Sep 2008

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U. Fagerholm. (2009) Presentation of a modified dispersion model (MDM) for hepatic drug extraction and a new methodology for the prediction of the rate-limiting step in hepatic metabolic clearance. Xenobiotica 39:1, pages 57-71.
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SK. Bezek, M. Kukan, W. F. Pool & T. F. Woolf. (1996) The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations. Xenobiotica 26:9, pages 935-946.
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Articles from other publishers (19)

Satoshi Koyama. (2021) Preliminary Flow Modeling by Hybrid Automata Alternating Continuous Reaction and Discrete Transit for Pharmacokinetics. Drug Metabolism and Disposition 49:7, pages 521-529.
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Sami Haddad. 2018. Chemical Mixtures and Combined Chemical and Nonchemical Stressors. Chemical Mixtures and Combined Chemical and Nonchemical Stressors 307 333 .
Lars Ole Schwen, Arne Schenk, Clemens Kreutz, Jens Timmer, María Matilde Bartolomé Rodríguez, Lars Kuepfer & Tobias Preusser. (2015) Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations. PLOS ONE 10:7, pages e0133653.
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Wolfgang Dekant & Spiridon Vamvakas. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Wolfgang Dekant & Spiridon Vamvakas. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Urban Fagerholm. (2007) Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance. Journal of Pharmacy and Pharmacology 59:6, pages 803-828.
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Elie Chalhoub, Richard W. Hanson & Joanne M. Belovich. (2007) A computer model of gluconeogenesis and lipid metabolism in the perfused liver. American Journal of Physiology-Endocrinology and Metabolism 293:6, pages E1676-E1686.
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E. Chalhoub, L. Xie, V. Balasubramanian, J. Kim & J. Belovich. (2006) A Distributed Model of Carbohydrate Transport and Metabolism in the Liver during Rest and High-Intensity Exercise. Annals of Biomedical Engineering 35:3, pages 474-491.
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Donald E. Mager. (2006) Quantitative structure–pharmacokinetic/pharmacodynamic relationships. Advanced Drug Delivery Reviews 58:12-13, pages 1326-1356.
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Wolfgang Dekant & Spiridon Vamvakas. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Graham Somers, Peter Mutch & Amanda Woodrooffe. 2004. A Handbook of Bioanalysis and Drug Metabolism. A Handbook of Bioanalysis and Drug Metabolism.
Frank-Peter Theil, Theodor W Guentert, Sami Haddad & Patrick Poulin. (2003) Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxicology Letters 138:1-2, pages 29-49.
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Balaji Agoram, Walter S. Woltosz & Michael B. Bolger. (2001) Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Advanced Drug Delivery Reviews 50, pages S41-S67.
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Kazuya Fukumura, Kiyoshi Yamaoka, Mitsuo Higashimori & Terumichi Nakagawa. (1999) Analysis program based on finite element method, MULTI(FEM), for evaluation of dose‐dependent local disposition of drug in liver. Journal of Pharmaceutical Sciences 88:5, pages 538-543.
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Marián Kukan. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 425 442 .
Gregory L. Kedderis. (1997) Extrapolation of in vitro enzyme induction data to humans in vivo. Chemico-Biological Interactions 107:1-2, pages 109-121.
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V. F. Kirichuk & A. N. Lutsevich. (1996) Modeling of drug elimination by the liver. 1. Main concepts and physiologically justified clearance models (a review). Pharmaceutical Chemistry Journal 30:5, pages 285-292.
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S. Patel, D. Kristol & A. Ritter. (1995) A pharmacokinetic model of the liver. A pharmacokinetic model of the liver.
E. Petzinger. 1982. Reviews of Physiology, Biochemistry and Pharmacology, Volume 94. Reviews of Physiology, Biochemistry and Pharmacology, Volume 94 47 211 .

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