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Drug Metabolism Reviews Volume 26, 1994 - Issue 3
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Research Article

Metabolism of Aziridines and the Mechanism of their Cytotoxicity

Yoshiteru Hata Shionogi Research Laboratories Shionogi and Company, Ltd., Fukushima-ku, Osaka, 553, Japan; Shionogi Research Laboratories Shionogi and Company, Ltd., 338 Sanso-cho, Izumishi, Osaka, 594, Japan
&
Masamichi Watanabe Shionogi Research Laboratories Shionogi and Company, Ltd., Fukushima-ku, Osaka, 553, Japan
Pages 575-604 | Published online: 22 Sep 2008

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Jayaprakasam Bolleddula, Kevin DeMent, James P. Driscoll, Philip Worboys, Patrick J. Brassil & David L. Bourdet. (2014) Biotransformation and bioactivation reactions of alicyclic amines in drug molecules. Drug Metabolism Reviews 46:3, pages 379-419.
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Articles from other publishers (10)

Fábio Z. Galetto, Cleiton da Silva, Ricardo I. M. Beche, Renata A. Balaguez, Marcelo S. Franco, Francisco F. de Assis, Tiago E. A. Frizon & Xiao Su. (2022) Decarboxylative ring-opening of 2-oxazolidinones: a facile and modular synthesis of β-chalcogen amines. RSC Advances 12:53, pages 34496-34502.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 495 547 .
Patricia HoyerAileen Keating. 2013. Ovarian Toxicology, Second Edition. Ovarian Toxicology, Second Edition 13 36 .
Valery M. Dembitsky, Alexander O. Terent’ev & Dmitri O. Levitsky. 2013. Natural Products. Natural Products 977 1006 .
Matthew R. Siebert & Dean J. Tantillo. (2011) Fundamental properties of N -alkenylaziridines-implications for the design of new reactions and organocatalysts . Journal of Physical Organic Chemistry 24:6, pages 445-449.
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Fyaz M.D. Ismail, Dmitri O. Levitsky & Valery M. Dembitsky. (2009) Aziridine alkaloids as potential therapeutic agents. European Journal of Medicinal Chemistry 44:9, pages 3373-3387.
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Hong Lu & Kenneth K. Chan. (2006) Pharmacokinetics of N-2-chloroethylaziridine, a volatile cytotoxic metabolite of cyclophosphamide, in the rat. Cancer Chemotherapy and Pharmacology 58:4, pages 532-539.
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B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg & W. H. Soine. (2002) Irreversible Inhibition of CYP2D6 by (−)-Chloroephedrine, a Possible Impurity in Methamphetamine. Drug Metabolism and Disposition 30:12, pages 1337-1343.
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Kuriya Madavu, Lokanatha Rai & Alfred Hassner. 2000. Advances in Strained and Interesting Organic Molecules Volume 8. Advances in Strained and Interesting Organic Molecules Volume 8 187 257 .
Neal Castagnoli,, John M. Rimoldi, Jeff Bloomquist & Kay P. Castagnoli. (1997) Potential Metabolic Bioactivation Pathways Involving Cyclic Tertiary Amines and Azaarenes. Chemical Research in Toxicology 10:9, pages 924-940.
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