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Research Article

Clinical Importance of Hepatic Cytochrome P450 in Drug Metabolism

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Pages 397-417 | Published online: 22 Sep 2008

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Shuting Wang, Xiange Tang, Tingting Yang, Jiong Xu, Jiaxin Zhang, Xiaodong Liu & Li Liu. (2019) Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes. Xenobiotica 49:2, pages 161-168.
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Maria Konstandi. (2013) Psychophysiological stress: a significant parameter in drug pharmacokinetics. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1317-1334.
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Amy Z Crepeau, Brian D Moseley & Elaine C Wirrell. (2012) Specific safety and tolerability considerations in the use of anticonvulsant medications in children. Drug, Healthcare and Patient Safety 4, pages 39-54.
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N. Sekiguchi, M. Kato, M. Takada, H. Watanabe, A. Higashida, S. Sakai, M. Ishigai & Y. Aso. (2008) approach for the evaluation of mechanism-based inhibition of cytochrome P450 3A in rats. Xenobiotica 38:4, pages 368-381.
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C. Emoto, H. Nishida, H. Hirai & K. Iwasaki. (2007) CYP3A4 and CYP3A5 catalyse the conversion of the -methyl-D-aspartate (NMDA) antagonist CJ-036878 to two novel dimers. Xenobiotica 37:12, pages 1408-1420.
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C. Emoto & K. Iwasaki. (2007) Relative roles of CYP2C19 and CYP3A4/5 in midazolam 1′-hydroxylation. Xenobiotica 37:6, pages 592-603.
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Jos V Castell, Ramiro Jover, Celia P Martnez-Jimnez & Mara Jos Gmez-Lechn. (2006) Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opinion on Drug Metabolism & Toxicology 2:2, pages 183-212.
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J. Venhorst, M. Rooseboom, N. P. E. Vermeulen & J. N. M. Commandeur. (2003) Studies on the inhibition of human cytochromes P450 by selenocysteine Se -conjugates. Xenobiotica 33:1, pages 57-72.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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D. D. Surry, G. Meneses-Lorente, R. Heavens, A. Jack & D. C. Evans. (2000) Rapid determination of rat hepatocyte mRNA induction potential using oligonucleotide probes for CYP1A1, 1A2, 3A and 4A1. Xenobiotica 30:5, pages 441-456.
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M. Nakajima, K. Kobayashi, K. Oshima, N. Shimada, S. Tokudome, K. Chiba & T. Yokoi. (1999) Activation of phenacetin O-deethylase activity by α-naphthoflavone in human liver microsomes. Xenobiotica 29:9, pages 885-898.
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M. Nakajima, M. Suzuki, R. Yamaji, H. Takashina, N. Shimada, H. Yamazaki & T. Yokoi. (1999) Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds. Xenobiotica 29:12, pages 1191-1202.
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D. MCKILLOP, M. J. WILD, C. J. BUTTERS & C. SIMCOCK. (1998) Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica 28:9, pages 845-853.
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Slobodan Rendic & Frederick J. Di Carlo. (1997) Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors. Drug Metabolism Reviews 29:1-2, pages 413-580.
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Edward T. Morgan. (1997) Regulation of Cytochromes P450 During Inflammation and Infection. Drug Metabolism Reviews 29:4, pages 1129-1188.
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