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Research Article

Phenytoin Disposition and Toxicity: Role of Pharmacogenetic and Interethnic Factors

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Pages 449-469 | Published online: 22 Sep 2008

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Lars W. Wormhoudt, Jan N. M. Commandeur & Nico P. E. Vermeulen. (1999) Genetic Polymorphisms of Human N-Acetyltransferase, Cytochrome P450, Glutathione-S-Transferase, and Epoxide Hydrolase Enzymes: Relevance to Xenobiotic Metabolism and Toxicity. Critical Reviews in Toxicology 29:1, pages 59-124.
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Chloé Bars, Jente Hoyberghs, Allan Valenzuela, Laura Buyssens, Miriam Ayuso, Chris Van Ginneken, Alain J. Labro, Kenn Foubert & Steven J. Van Cruchten. (2021) Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae. International Journal of Molecular Sciences 22:23, pages 12696.
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Jiri Patocka, Qinghua Wu, Eugenie Nepovimova & Kamil Kuca. (2020) Phenytoin – An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology. Food and Chemical Toxicology 142, pages 111393.
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Jinju Guk, Sang-Guk Lee, Dongwoo Chae, Jeong-Ho Kim & Kyungsoo Park. (2019) Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. Journal of Pharmaceutical Sciences 108:8, pages 2765-2773.
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Stefan Weigt, Nicole Huebler, Ruben Strecker, Thomas Braunbeck & Thomas H. Broschard. (2011) Zebrafish (Danio rerio) embryos as a model for testing proteratogens. Toxicology 281:1-3, pages 25-36.
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Chin-Chuan Hung, Chun-Jung Lin, Chih-Chuan Chen, Chee-Jen Chang & Horng-Huei Liou. (2004) Dosage Recommendation of Phenytoin for Patients with Epilepsy with Different CYP2C9/CYP2C19 Polymorphisms. Therapeutic Drug Monitoring 26:5, pages 534-540.
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Thorir D. Bjornsson, John A. Wagner, Stephen R. Donahue, Dawn Harper, Aziz Karim, Marlene S. Khouri, William R. Murphy, Kristin Roman, Dennis Schneck, Daryl S. Sonnichsen, Dennis J. Stalker, Stephen D. Wise, Stuart Dombey & Caroline Loew. (2013) A Review and Assessment of Potential Sources of Ethnic Differences in Drug Responsiveness. The Journal of Clinical Pharmacology 43:9, pages 943-967.
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Hong-Guang XieRichard B KimAlastair JJ WoodC Michael Stein. (2001) Molecular Basis of Ethnic Differences in Drug Disposition and Response. Annual Review of Pharmacology and Toxicology 41:1, pages 815-850.
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H. Kutt & C. L. Harden. 1999. Antiepileptic Drugs. Antiepileptic Drugs 229 265 .
Julie A. Johnson. (1997) Influence of Race or Ethnicity on Pharmacokinetics of Drugs. Journal of Pharmaceutical Sciences 86:12, pages 1328-1333.
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Edyta J Frackiewicz, John J Sramek, John M Herrera, Neil M Kurtz & Neal R Cutler. (2016) Ethnicity and Antipsychotic Response. Annals of Pharmacotherapy 31:11, pages 1360-1369.
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