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Research Article

Receptor-Selective Retinoid Agonists and Teratogenic Activity

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Pages 105-119 | Published online: 22 Sep 2008

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Harish Srinivas, Denise M. Juroske, Shailaja Kalyankrishna, Dianna D. Cody, Roger E. Price, Xiao-Chun Xu, Ramesh Narayanan, Nancy L. Weigel & Jonathan M. Kurie. (2005) c-Jun N-Terminal Kinase Contributes to Aberrant Retinoid Signaling in Lung Cancer Cells by Phosphorylating and Inducing Proteasomal Degradation of Retinoic Acid Receptor α. Molecular and Cellular Biology 25:3, pages 1054-1069.
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Deborah L. Osburn, Gang Shao, H. Martin Seidel & Ira G. Schulman. (2001) Ligand-Dependent Degradation of Retinoid X Receptors Does Not Require Transcriptional Activity or Coactivator Interactions. Molecular and Cellular Biology 21:15, pages 4909-4918.
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Articles from other publishers (17)

Keith A. Houck, Grace Patlewicz, Ann M. Richard, Antony J. Williams, Mahmoud A. Shobair, Marci Smeltz, M. Scott Clifton, Barbara Wetmore, Alex Medvedev & Sergei Makarov. (2021) Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure. Toxicology 457, pages 152789.
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Aziza Hussein Bakheit Adam, Laura H. J. de Haan, Ignacio Miro Estruch, Guido J. E. J. Hooiveld, Jochem Louisse & Ivonne M. C. M. Rietjens. (2020) Estrogen receptor alpha (ERα)–mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2). Cell Biology and Toxicology 36:5, pages 417-435.
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Shayne C. Gad. 2019. Biomarkers in Toxicology. Biomarkers in Toxicology 7 73 .
Jingmin Zhu, Amanda Janesick, Lijiao Wu, Lingling Hu, Weiyi Tang, Bruce Blumberg & Huahong Shi. (2017) The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicology and Applied Pharmacology 314, pages 91-97.
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Shayne Gad & Frederick Hess. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 285 340 .
Shayne C. Gad. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 7 69 .
Shengde Wu, Joan Fisher, Jorge Naciff, Michael Laufersweiler, Cathy Lester, George Daston & Karen Blackburn. (2013) Framework for Identifying Chemicals with Structural Features Associated with the Potential to Act as Developmental or Reproductive Toxicants. Chemical Research in Toxicology 26:12, pages 1840-1861.
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Malcolm Maden. (2006) Retinoids Have Differing Efficacies on Alveolar Regeneration in a Dexamethasone-Treated Mouse. American Journal of Respiratory Cell and Molecular Biology 35:2, pages 260-267.
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Olubunmi Afonja, Bruce M Raaka, Ambrose Huang, Sharmistha Das, Xinyu Zhao, Elizabeth Helmer, Dominique Juste & Herbert H Samuels. (2002) RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. Oncogene 21:51, pages 7850-7860.
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Yutaka Haga, Tohru Suzuki & Toshio Takeuchi. (2002) Retinoic Acid Isomers Produce Malformations in Postembryonic Development of the Japanese Flounder, Paralichthys olivaceus. Zoological Science 19:10, pages 1105-1112.
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Bruno P Klaholz, André Mitschler & Dino Moras. (2000) Structural basis for isotype selectivity of the human retinoic acid nuclear receptor 1 1Edited by T. Richmond. Journal of Molecular Biology 302:1, pages 155-170.
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Mehraneh Khalighi, MonicaR Brzezinski, Hao Chen & MontR Juchau. (1999) Inhibition of human prenatal biosynthesis of all-trans-retinoic acid by ethanol, ethanol metabolites, and products of lipid peroxidation reactions. Biochemical Pharmacology 57:7, pages 811-821.
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Haisu Wan, Marcia I. Dawson, Waun K. Hong & Reuben Lotan. (1998) Overexpressed Activated Retinoid X Receptors Can Mediate Growth Inhibitory Effects of Retinoids in Human Carcinoma Cells. Journal of Biological Chemistry 273:41, pages 26915-26922.
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Giuseppe Giannini, Marcia I. Dawson, Xiao-kun Zhang & Carol J. Thiele. (1997) Activation of Three Distinct RXR/RAR Heterodimers Induces Growth Arrest and Differentiation of Neuroblastoma Cells. Journal of Biological Chemistry 272:42, pages 26693-26701.
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Mohamed M.A. Elmazar, Ralph Rühl, Uwe Reichert, Braham Shroot & Heinz Nau. (1997) RARα-Mediated Teratogenicity in Mice Is Potentiated by an RXR Agonist and Reduced by an RAR Antagonist: Dissection of Retinoid Receptor-Induced Pathways. Toxicology and Applied Pharmacology 146:1, pages 21-28.
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Christian Eckhoff & Calvin C. Willhite. (1997) Embryonic Delivered Dose of Isotretinoin (13-cis-Retinoic Acid) and Its Metabolites in Hamsters. Toxicology and Applied Pharmacology 146:1, pages 79-87.
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Richard M. Eglen, Mont R. Juchau, Gillian Edwards, Arthur H. Weston, Helen Wise, M. D. Murray, D. Craig Brater, Olivier Valdenaire, Philippe Vernier & Annemarie PolakMont R. Juchau. 1997. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques 25 92 .

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