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Research Article

Past, Present, and Future Applications of Precision-Cut Liver Slices for in Vitro Xenobiotic Metabolism

Pages 591-623 | Published online: 22 Sep 2008

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María Laura Maté, Mariana Ballent, Karen Larsen, Adrian Lifschitz, Carlos Lanusse & Guillermo Virkel. (2015) Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices. Xenobiotica 45:7, pages 563-570.
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Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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M. Umachandran, J. Howarth & C. Ioannides. (2004) Metabolic and structural viability of precision-cut rat lung slices in culture. Xenobiotica 34:8, pages 771-780.
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Rolf Gebhardt, Jan G. Hengstler, Dieter Müller, Reinhild Glöckner, Peter Buenning, Britta Laube, Eva Schmelzer, Martina Ullrich, Dietmar Utesch, Nicola Hewitt, Michael Ringel, Beate Reder Hilz, Augustinus Bader, Angelika Langsch, Thomas Koose, Hans-Jörg Burger, Jochen Maas & Franz Oesch. (2003) New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures. Drug Metabolism Reviews 35:2-3, pages 145-213.
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Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, Anlong Xu & James W. Paxton. (2003) Interactions of Herbs with Cytochrome P450. Drug Metabolism Reviews 35:1, pages 35-98.
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C. Granhall, E. Floby, A. Nordmark, A. Orzechowski, A. Thörne, G. Tybring & A.-K. Sohlenius-Sternbeck. (2002) Characterization of testosterone metabolism and 7-hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months. Xenobiotica 32:11, pages 985-996.
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D. C. Mankowski, M. P. Lawton & S. Ekins. (2000) Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates. Xenobiotica 30:8, pages 745-754.
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A.-K. Sohlenius-Sternbeck, E. Floby, M. Svedling & A. Orzechowski. (2000) High conservation of both phase I and II drug-metabolizing activities in cryopreserved rat liver slices. Xenobiotica 30:9, pages 891-903.
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L. Maté, M. Giantin, P. Viviani, M. Ballent, R. Tolosi, A. Lifschitz, C. Lanusse, M. Dacasto & G. Virkel. (2019) Effects of fenbendazole and triclabendazole on the expression of cytochrome P450 1A and flavin-monooxygenase isozymes in bovine precision-cut liver slices. The Veterinary Journal 245, pages 61-69.
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