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Research Article

Pharmacokinetics and Pharmacodynamics of a Recombinant Human Granulocyte Colony-Stimulating Factor

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Pages 625-658 | Published online: 22 Sep 2008

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Angelica L. Quartino, Mats O. Karlsson, Henrik Lindman & Lena E. Friberg. (2014) Characterization of Endogenous G-CSF and the Inverse Correlation to Chemotherapy-Induced Neutropenia in Patients with Breast Cancer Using Population Modeling. Pharmaceutical Research 31:12, pages 3390-3403.
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Melody K. Morris, Zachary Shriver, Ram Sasisekharan & Douglas A. Lauffenburger. (2012) Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions. Biotechnology Journal 7:3, pages 374-386.
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Bing-Bing Yang, Michael A. Savin & Michael Green. (2012) Prevention of Chemotherapy-Induced Neutropenia with Pegfilgrastim: Pharmacokinetics and Patient Outcomes. Chemotherapy 58:5, pages 387-398.
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Lorin K. Roskos. 2012. Twenty Years of G-CSF. Twenty Years of G-CSF 41 60 .
Pellegrino Musto. 2012. Twenty Years of G-CSF. Twenty Years of G-CSF 211 223 .
Bing-Bing Yang & Anna Kido. (2011) Pharmacokinetics and Pharmacodynamics of Pegfilgrastim. Clinical Pharmacokinetics 50:5, pages 295-306.
Crossref
T. V. Andreeva, A. V. Artamonov, A. A. Bekarev, E. I. Vereschagin, P. G. Madonov, O. V. Pershina, E. G. Skurikhin, E. S. Khmelevskaya & A. M. Dygai. (2011) Role of Stromal and Thy 1,2+ Cells in the Mechanisms of Action of Immobilized Granulocyte Colony-Stimulating Factor during Cytostatic-Induced Myelosuppression. Bulletin of Experimental Biology and Medicine 150:5, pages 594-598.
Crossref
Diane R. Mould. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development 57 90 .
Lorin K. Roskos, Song Ren & Gabriel Robbie. 2011. Clinical Trial Simulations. Clinical Trial Simulations 361 396 .
Azzurra Romeo, Anna Chierichini, Alessandra Spagnoli, Mariangela Vittori, Michele Vacca, Maria Gozzer, Antonio Spadea, Barbara Anaclerico, Maria Laura Dessanti, Mariella D'Andrea, Giuseppe Toglia, Luciana Annino, Maria Concetta Petti, Andrea Mengarelli & William Arcese. (2010) Standard- versus high-dose lenograstim in adults with hematologic malignancies for peripheral blood progenitor cell mobilization. Transfusion 50:11, pages 2432-2446.
Crossref
Cornelius F. Waller, Miguel Bronchud, Stuart Mair & Rodeina Challand. (2010) Comparison of the pharmacodynamic profiles of a biosimilar filgrastim and Amgen filgrastim: results from a randomized, phase I trial. Annals of Hematology 89:10, pages 971-978.
Crossref
A. M. Dygai, E. G. Skurikhin, T. V. Andreeva, P. G. Madonov, E. I. Vereshagin, D. N. Kinsht, O. V. Pershina & E. S. Khmelevskaya. (2010) Effect of Immobilized Granulocyte Colony-Stimulating Factor on Hemopoietic Precursors of Various Classes during Cytostatic-Induced Myelosuppression. Bulletin of Experimental Biology and Medicine 149:3, pages 284-288.
Crossref
R Ria, T Gasparre, G Mangialardi, A Bruno, G Iodice, A Vacca & F Dammacco. (2009) Comparison between filgrastim and lenograstim plus chemotherapy for mobilization of PBPCs. Bone Marrow Transplantation 45:2, pages 277-281.
Crossref
M. Scholz, C. Engel, D. Apt, S. L. Sankar, E. Goldstein & M. Loeffler. (2009) Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in rats. Cell Proliferation 42:6, pages 823-837.
Crossref
M. Scholz, M. Ackermann, C. Engel, F. Emmrich, M. Loeffler & M. Kamprad. (2009) A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide-induced granulocytopaenia. Cell Proliferation 42:6, pages 813-822.
Crossref
Gary H. Lyman, Anjana Lalla, Richard L. Barron & Robert W. Dubois. (2009) Cost-effectiveness of pegfilgrastim versus filgrastim primary prophylaxis in women with early-stage breast cancer receiving chemotherapy in the united states. Clinical Therapeutics 31:5, pages 1092-1104.
Crossref
M. Hofer, M. Pospíšil, J. Holá, A. Vacek, D. Štreitová & V. Znojil. (2008) Inhibition of Cyclooxygenase 2 in Mice Increases Production of G-CSF and Induces Radioprotection. Radiation Research 170:5, pages 566-571.
Crossref
Bing‐Bing Yang, Anna Kido, Margaret Salfi, Suzanne Swan & John T. Sullivan. (2013) Pharmacokinetics and Pharmacodynamics of Pegfilgrastim in Subjects With Various Degrees of Renal Function. The Journal of Clinical Pharmacology 48:9, pages 1025-1031.
Crossref
Maria Liljefors, Bo Nilsson, Håkan Mellstedt & Jan-Erik Frödin. (2007) Influence of varying doses of granulocyte-macrophage colony-stimulating factor on pharmacokinetics and antibody-dependent cellular cytotoxicity. Cancer Immunology, Immunotherapy 57:3, pages 379-388.
Crossref
Alberto Ballestrero, Davide Boy, Roberta Gonella, Maurizio Miglino, Marino Clavio, Valentina Barbero, Alessio Nencioni, Marco Gobbi & Franco Patrone. (2007) Pegfilgrastim compared with filgrastim after autologous peripheral blood stem cell transplantation in patients with solid tumours and lymphomas. Annals of Hematology 87:1, pages 49-55.
Crossref
Bing‐Bing Yang, Anna Kido & Atsuko Shibata. (2012) Serum Pegfilgrastim Concentrations During Recovery of Absolute Neutrophil Count in Patients with Cancer Receiving Pegfilgrastim After Chemotherapy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 27:10, pages 1387-1393.
Crossref
Kazumi Komoriya, Yukio Kato, Yujiro Hayashi, Kazuhiro Ohsuye, Ryuichiro Nishigaki & Yuichi Sugiyama. (2007) Characterization of the Hepatic Disposition of Lanoteplase, a Rationally Designed Variant of Tissue Plasminogen Activator in Rodents. Drug Metabolism and Disposition 35:3, pages 469-475.
Crossref
Gaëtan Vanstraelen, Pascale Frère, Marie-Christine Ngirabacu, Evelyne Willems, Georges Fillet & Yves Beguin. (2006) Pegfilgrastim compared with Filgrastim after autologous hematopoietic peripheral blood stem cell transplantation. Experimental Hematology 34:3, pages 382-388.
Crossref
Johannes C. Fischer, Markus Frick, Ralf Wassmuth, Alexander Platz, Michael Punzel & Peter Wernet. (2005) Superior mobilisation of haematopoietic progenitor cells with glycosylated G-CSF in male but not female unrelated stem cell donors. British Journal of Haematology 130:5, pages 740-746.
Crossref
V. Vainstein, Y. Ginosar, M. Shoham, D.O. Ranmar, A. Ianovski & Z. Agur. (2005) The complex effect of granulocyte colony-stimulating factor on human granulopoiesis analyzed by a new physiologically-based mathematical model. Journal of Theoretical Biology 234:3, pages 311-327.
Crossref
Francisco Hernández-Bernal, Idrian García-García, Carlos A. González-Delgado, Carmen Valenzuela-Silva, Ramón Soto-Hernández, Jorge Ducongé, Majel Cervantes-Llano, Elizabeth Blanco-Garcés, Víctor Rodríguez, Yanelda García-Vega, Iraldo Bello-Rivero, Lourdes Olivera-Ruano & Pedro López-Saura. (2005) Bioequivalence of two recombinant granulocyte colony-stimulating factor formulations in healthy male volunteers. Biopharmaceutics & Drug Disposition 26:4, pages 151-159.
Crossref
Munetoshi SUGIURA, Yoshiyuki OHNO, Yasuhiko YAMADA, Hiroshi SUZUKI & Tatsuji IGA. (2004) Pharmacokinetic/Pharmacodynamic Analysis of Neutrophil Proliferation Induced by rhG-CSF in Patients Receiving Antineoplastic Drugs. YAKUGAKU ZASSHI 124:9, pages 599-604.
Crossref
Nicolaus Kröger, Stefan Sonnenberg, Lourdes Cortes-Dericks, Petra Freiberger, Hanke Mollnau & Axel R. Zander. (2004) Kinetics of G-CSF and CD34+ cell mobilization after once or twice daily stimulation with rHu granulocyte-stimulating factor (lenograstim) in healthy volunteers: an intraindividual crossover study. Transfusion 44:1, pages 104-110.
Crossref
Daan J.A. Crommelin, Gert Storm, Ruud Verrijk, Leo de Leede, Wim Jiskoot & Wim E. Hennink. (2003) Shifting paradigms: biopharmaceuticals versus low molecular weight drugs. International Journal of Pharmaceutics 266:1-2, pages 3-16.
Crossref
Adam M Persky, Gayle A Brazeau & G??nther Hochhaus. (2003) Pharmacokinetics of the Dietary Supplement Creatine. Clinical Pharmacokinetics 42:6, pages 557-574.
Crossref
Thomas Hartung, Sonja von Aulock, Christian Schneider & Eugen Faist. (2003) How to leverage an endogenous immune defense mechanism: The example of granulocyte colony-stimulating factor. Critical Care Medicine 31:Supplement, pages S65-S75.
Crossref
Zenaide Quezado, Chantal Parent, Waheedullah Karzai, Michael Depietro, Charles Natanson, William Hammond, Robert L. Danner, Xizhong Cui, Yvonne Fitz, Steven M. Banks, Eric Gerstenberger & Peter Q. Eichacker. (2001) Acute G-CSF therapy is not protective during lethal E. coli sepsis . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 281:4, pages R1177-R1185.
Crossref
Masaaki Fukuda, Mikio Oka, Yoshimasa Ishida, Haruki Kinoshita, Kenji Terashi, Minoru Fukuda, Shigeru Kawabata, Akitoshi Kinoshita, Hiroshi Soda & Shigeru Kohno. (2001) Effects of Renal Function on Pharmacokinetics of Recombinant Human Granulocyte Colony-Stimulating Factor in Lung Cancer Patients. Antimicrobial Agents and Chemotherapy 45:7, pages 1947-1951.
Crossref
S Akizuki, F Mizorogi, T Inoue, K Sudo & A Ohnishi. (2000) Pharmacokinetics and adverse events following 5-day repeated administration of lenograstim, a recombinant human granulocyte colony-stimulating factor, in healthy subjects. Bone Marrow Transplantation 26:9, pages 939-946.
Crossref
Darlene A. Calhoun & Robert D. Christensen. (2000) HUMAN DEVELOPMENTAL BIOLOGY OF GRANULOCYTE COLONY-STIMULATING FACTOR. Clinics in Perinatology 27:3, pages 559-576.
Crossref
Darlene A. CalhounMathilde LunøeYan DuAlan D. HutsonMark VeermanRobert D. Christensen. (2000) Granulocyte Colony-Stimulating Factor Serum and Urine Concentrations in Neutropenic Neonates Before and After Intravenous Administration of Recombinant Granulocyte Colony-Stimulating Factor. Pediatrics 105:2, pages 392-397.
Crossref
Luigi Rotondaro, Enrico De Paolis, Dario Ferrero, Laura D’Alatri, Giuseppe Raucci, Armando Fabbri, Gerrit J. Gerwig, Johannis P. Kamerling, Maurizio F. Mariani, Antonio Mele & Rita De Santis. (1999) Purification and characterization of two recombinant human granulocyte colony-stimulating factor glycoforms. Molecular Biotechnology 11:2, pages 117-128.
Crossref
Sharon Bowen, Nadine Tare, Tomoaki Inoue, Motoo Yamasaki, Masami Okabe, Ikuo Horii & James F Eliason. (1999) Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein. Experimental Hematology 27:3, pages 425-432.
Crossref
Karen Li, Annie Wong, Chi Kong Li, Matthew Ming Kong Shing, Ki Wai Chik, Kam Sze Tsang, Howard Lai, Ting Fan Leung & Patrick Man Pan Yuen. (1999) Granulocyte colony–stimulating factor–mobilized peripheral blood stem cells in β-thalassemia patients. Experimental Hematology 27:3, pages 526-532.
Crossref
Yiqing Feng & John McKearn. 1999. Clinical Applications of Cytokines and Growth Factors. Clinical Applications of Cytokines and Growth Factors 90 116 .

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