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Original Article

Covalent Binding of Xenobiotics to Specific Proteins in the Liver

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Pages 39-57 | Published online: 15 Feb 2010

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Qingning Liang, Yuchen Sheng, Lili Ji, Yang Min, Yuye Xia & Zhengtao Wang. (2010) Acetaminophen-induced cytotoxicity on human normal liver L-02 cells and the protection of antioxidants. Toxicology Mechanisms and Methods 20:5, pages 273-278.
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G. Randall Bond. (2009) Acetaminophen protein adducts: A review. Clinical Toxicology 47:1, pages 2-7.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Jennie L. Walgren, Michael D. Mitchell & David C. Thompson. (2005) Role of Metabolism in Drug-Induced Idiosyncratic Hepatotoxicity. Critical Reviews in Toxicology 35:4, pages 325-361.
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Alastair E. Cribb, Mathieu Peyrou, Shanmugam Muruganandan & Laetitia Schneider. (2005) The Endoplasmic Reticulum in Xenobiotic Toxicity. Drug Metabolism Reviews 37:3, pages 405-442.
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M. Hojo, K. Hanioka, M. Miyata & Y. Yamazoe. (2000) Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose. Xenobiotica 30:9, pages 933-941.
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Jian Wu, Åke Danielsson & Mark A Zern. (1999) Toxicity of hepatotoxins: new insights into mechanisms and therapy. Expert Opinion on Investigational Drugs 8:5, pages 585-607.
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Lihong Gong, Li Liao, Xuyang Dai, Xinyan Xue, Cheng Peng & Yunxia Li. (2021) The dual role of immune response in acetaminophen hepatotoxicity: Implication for immune pharmacological targets. Toxicology Letters 351, pages 37-52.
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Thomas A. Baillie. (2020) Drug–protein adducts: past, present, and future. Medicinal Chemistry Research 29:7, pages 1093-1104.
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Ravindrababu Pingili, A. Krishnamanjari Pawar & Siva Reddy Challa. (2019) Quercetin reduced the formation of N ‐acetyl‐ p ‐benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes . Phytotherapy Research 33:7, pages 1770-1783.
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Ravindra Babu Pingili, A. Krishnamanjari Pawar & Siva R. Challa. (2019) Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes. Chemico-Biological Interactions 302, pages 123-134.
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Henry Ademola Adeola, Jennifer Cathryn Van Wyk, Afolake Temitope Arowolo & Nonhlanhla Patience Khumalo. 2018. Keratin. Keratin.
Yong-Ha Lim, Ji-Won Jeong, Sun-Gil Kim, Ji-Hoon Kim & Seon-Jong Kim. (2018) DRF and Single Dose Oral Toxicity Study of ChondroT in Rat. Journal of Korean Medicine Rehabilitation 28:2, pages 61-72.
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Imane Saad Albichr & Philippe Hantson. (2018) Le paracétamol à dose thérapeutique : quelles populations à risque d’hépatotoxicité ?. Toxicologie Analytique et Clinique 30:1, pages 19-34.
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Landon R. Whitby, R. Scott Obach, Gabriel M. Simon, Matthew M. Hayward & Benjamin F. Cravatt. (2017) Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites . ACS Chemical Biology 12:8, pages 2040-2050.
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Jinping Gan, Haiying Zhang & W. Griffith Humphreys. (2016) Drug–Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization. Chemical Research in Toxicology 29:12, pages 2040-2057.
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Huiying Luo, Rongrong Cao, Lijuan Wang & Lijuan Zhu. (2016) Protective effect of Cistanchis A on ethanol-induced damage in primary cultured mouse hepatocytes. Biomedicine & Pharmacotherapy 83, pages 1071-1079.
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Hong-Min Ni, Mitchell R. McGill, Xiaojuan Chao, Kuo Du, Jessica A. Williams, Yuchao Xie, Hartmut Jaeschke & Wen-Xing Ding. (2016) Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice. Journal of Hepatology 65:2, pages 354-362.
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Mitchell R. McGill & Hartmut Jaeschke. (2013) Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research 30:9, pages 2174-2187.
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