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Original Article

Selective Protein Arylation and Acetaminophen-Induced Hepatotoxicity

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Pages 59-77 | Published online: 15 Feb 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Angela L. Chiew & Geoffrey K. Isbister. (2023) Advances in the understanding of acetaminophen toxicity mechanisms: a clinical toxicology perspective. Expert Opinion on Drug Metabolism & Toxicology 0:0, pages 1-16.
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Mitchell R. McGill & Jack A. Hinson. (2020) The development and hepatotoxicity of acetaminophen: reviewing over a century of progress. Drug Metabolism Reviews 52:4, pages 472-500.
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Valerie Walker, Graham A. Mills, Mary E. Anderson, Brandall L. Ingle, John M. Jackson, Charlotte L. Moss, Hayley Sharrod-Cole & Paul J. Skipp. (2017) The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?. Xenobiotica 47:2, pages 164-175.
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S. Gosselin, D. N. Juurlink, J. T. Kielstein, M. Ghannoum, V. Lavergne, T. D. Nolin & R. S. Hoffman. (2014) Extracorporeal treatment for acetaminophen poisoning: Recommendations from the EXTRIP workgroup. Clinical Toxicology 52:8, pages 856-867.
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Mitchell R McGill & Hartmut Jaeschke. (2014) Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opinion on Drug Metabolism & Toxicology 10:7, pages 1005-1017.
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Kasturi Sarkar & Parames C. Sil. (2007) Attenuation of Acetaminophen-Induced Hepatotoxicity In Vivo and In Vitro by a 43-kD Protein Isolated from the Herb Cajanus indicus L. Toxicology Mechanisms and Methods 17:6, pages 305-315.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Jack A. Hinson, Angela B. Reid, Sandra S. McCullough & Laura P. James. (2004) Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition. Drug Metabolism Reviews 36:3-4, pages 805-822.
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M. Hojo, K. Hanioka, M. Miyata & Y. Yamazoe. (2000) Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose. Xenobiotica 30:9, pages 933-941.
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