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Drug Metabolism Reviews Volume 29, 1997 - Issue 3
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Original Article

Modeling the Active Sites of Cytochrome P450s and Glutathione S-Transferases, two of the Most Important Biotransformation Enzymes

Marcel J. De Groot Leiden/Amsterdam Center for Drug Research Divisions of Molecular Toxicology and Medicinal Chemistry, Department of Pharmacochemistry Vrije Universiteit, De Boelelaan, 1083 1081HV, Amsterdam, The Netherlands
&
Nico P. E. Vermeulen Leiden/Amsterdam Center for Drug Research Divisions of Molecular Toxicology and Medicinal Chemistry, Department of Pharmacochemistry Vrije Universiteit, De Boelelaan, 1083 1081HV, Amsterdam, The NetherlandsCorrespondence[email protected]
Pages 747-799 | Published online: 15 Feb 2010

Citations (16)

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Lars W. Wormhoudt, Jan N. M. Commandeur & Nico P. E. Vermeulen. (1999) Genetic Polymorphisms of Human N-Acetyltransferase, Cytochrome P450, Glutathione-S-Transferase, and Epoxide Hydrolase Enzymes: Relevance to Xenobiotic Metabolism and Toxicity. Critical Reviews in Toxicology 29:1, pages 59-124.
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Ellen M. Van Der Aar, Kian T. Tan, Jan N. M. Commandeur & Nico P. E. Vermeulen. (1998) Strategies to Characterize the Mechanisms of Action and the Active Sites of Glutathione S-Transferases: A Review. Drug Metabolism Reviews 30:3, pages 569-643.
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Articles from other publishers (14)

Rim Khlifi, Olfa Messaoud, Ahmed Rebai & Amel Hamza-Chaffai. (2013) Polymorphisms in the Human Cytochrome P450 and Arylamine N -Acetyltransferase: Susceptibility to Head and Neck Cancers . BioMed Research International 2013, pages 1-20.
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Kazuya Yasuo, Noriyuki Yamaotsu, Hiroaki Gouda, Hideki Tsujishita & Shuichi Hirono. (2009) Structure-Based CoMFA As a Predictive Model - CYP2C9 Inhibitors As a Test Case. Journal of Chemical Information and Modeling 49:4, pages 853-864.
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Kenneth Bachmann. 2009. Pharmacology. Pharmacology 131 173 .
Thomas Fox & Jan M. Kriegl. 2007. 63 81 .
Bernard Testa, Anne-Loyse Balmat, Anthony Long & Philip Judson. (2005) Predicting Drug Metabolism - An Evaluation of the Expert SystemMETEOR. Chemistry & Biodiversity 2:7, pages 872-885.
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Shahriar Haji-Momenian, Jayson M Rieger, Timothy L Macdonald & Milton L Brown. (2003) Comparative molecular field analysis and QSAR on substrates binding to cytochrome P450 2D6. Bioorganic & Medicinal Chemistry 11:24, pages 5545-5554.
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Jennifer Venhorst, Antonius M ter Laak, Moira Meijer, Ineke van de Wetering, Jan N.M Commandeur, Martijn Rooseboom & Nico P.E Vermeulen. (2003) Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate β-lyase. Journal of Molecular Graphics and Modelling 22:1, pages 55-70.
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Donald J. AbrahamBernard Testa & William Soine. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 431 498 .
Jun Xu & Arnold Hagler. (2002) Chemoinformatics and Drug Discovery. Molecules 7:8, pages 566-600.
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György M. Keserűu & László Molnár. (2002) METAPRINT:  A Metabolic Fingerprint. Application to Cassette Design for High-Throughput ADME Screening. Journal of Chemical Information and Computer Sciences 42:2, pages 437-444.
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Marcel J. de Groot & Sean Ekins. (2002) Pharmacophore modeling of cytochromes P450. Advanced Drug Delivery Reviews 54:3, pages 367-383.
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Qinmi Wang & James R. Halpert. (2002) Combined Three-Dimensional Quantitative Structure-Activity Relationship Analysis of Cytochrome P450 2B6 Substrates and Protein Homology Modeling. Drug Metabolism and Disposition 30:1, pages 86-95.
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. 2002. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists 121 168 .
David Lewis. 2001. Guide to Cytochromes P450. Guide to Cytochromes P450 164 210 .

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