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Research Article

Stereoselectivity in S- and N-Oxygenation by the Mammalian Flavin-Containing and Cytochrome P-450 Monooxygenases

Pages 675-707 | Published online: 22 Sep 2008

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Bernard Testa. (2015) Types of stereoselectivity in drug metabolism: a heuristic approach. Drug Metabolism Reviews 47:2, pages 239-251.
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G. Virkel, A. Lifschitz, J. Sallovitz, L. Maté, C. Farías & C. Lanusse. (2014) In vitro and in vivo assessment of the benzydamine-mediated interference with the hepatic S-oxidation of the anthelmintic albendazole in sheep. Small Ruminant Research 120:1, pages 142-149.
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Bettencourt P.S. Capece, Guillermo L. Virkel & Carlos E. Lanusse. (2009) Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications. The Veterinary Journal 181:3, pages 241-250.
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Zsolt Bikádi & Eszter Hazai. (2008) In silico description of differential enantioselectivity in methoxychlor O-demethylation by CYP2C enzymes. Biochimica et Biophysica Acta (BBA) - General Subjects 1780:9, pages 1070-1079.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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John R. CashmanJun Zhang. (2006) HUMAN FLAVIN-CONTAINING MONOOXYGENASES. Annual Review of Pharmacology and Toxicology 46:1, pages 65-100.
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John R. Cashman. (2005) Some distinctions between flavin-containing and cytochrome P450 monooxygenases. Biochemical and Biophysical Research Communications 338:1, pages 599-604.
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Bindhu V. Karanam, Christopher J. Welch, Vijay G. Reddy, Jennifer Chilenski, Mirlinda Biba & Stella Vincent. (2004) SPECIES DIFFERENTIAL STEREOSELECTIVE OXIDATION OF A METHYLSULFIDE METABOLITE OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY- N -[[(4-TRIFLUOROMETHYL)PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DUAL AGONIST . Drug Metabolism and Disposition 32:10, pages 1061-1068.
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John R Cashman. (2004) The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development. Drug Discovery Today 9:13, pages 574-581.
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G. Virkel, A. Lifschitz, J. Sallovitz, A. Pis & C. Lanusse. (2004) COMPARATIVE HEPATIC AND EXTRAHEPATIC ENANTIOSELECTIVE SULFOXIDATION OF ALBENDAZOLE AND FENBENDAZOLE IN SHEEP AND CATTLE. Drug Metabolism and Disposition 32:5, pages 536-544.
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Diana Hernandez, Azara Janmohamed, Pritpal Chandan, Ian R Phillips & Elizabeth A Shephard. (2004) Organization and evolution of the flavin-containing monooxygenase genes of human and mouse. Pharmacogenetics 14:2, pages 117-130.
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John R. Cashman & Jun Zhang. (2002) Interindividual Differences of Human Flavin-Containing Monooxygenase 3: Genetic Polymorphisms and Functional Variation. Drug Metabolism and Disposition 30:10, pages 1043-1052.
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Megumi Kubota, Yoko Nakamoto, Kazuo Nakayama, Pailin Ujjin, Soisungwan Satarug, Taisei Mushiroda, Tsuyoshi Yokoi, Masato Funayama & Tetsuya Kamataki. (2002) A Mutation in the Flavin-containing Monooxygenase 3 Gene and its Effects on Catalytic Activity for N-oxidation of Trimethylamine In Vitro. Drug Metabolism and Pharmacokinetics 17:3, pages 207-213.
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Sharon K. Krueger, Sarah R. Martin, Mei-Fei Yueh, Clifford B. Pereira & David E. Williams. (2002) Identification of Active Flavin-Containing Monooxygenase Isoform 2 in Human Lung and Characterization of Expressed Protein. Drug Metabolism and Disposition 30:1, pages 34-41.
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