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David S. Wishart. (2005) Bioinformatics in Drug Development and Assessment. Drug Metabolism Reviews 37:2, pages 279-310.
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DAVID F. V. LEWIS. (1999) FRONTIER ORBITALS IN CHEMICAL AND BIOLOGICAL ACTIVITY: QUANTITATIVE RELATIONSHIPS AND MECHANISTIC IMPLICATIONS*. Drug Metabolism Reviews 31:3, pages 755-816.
Read now
Read now
Articles from other publishers (23)
D. Manikandan, J. Swaminathan, S. Sharmila Tagore, S. Gomathi, N. Sabarinathan, M. Ramalingam, K. Balasubramani & V. Sethuraman. (2020) Crystallographic, spectral and computational studies on (S)-4-(4-aminobenzyl) oxazolidin-2-one. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 239, pages 118484.
Crossref
Crossref
Agostino Bruno, Gabriele Costantino, Luca Sartori & Marco Radi. (2019) The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization. Current Medicinal Chemistry 26:21, pages 3838-3873.
Crossref
Crossref
S. Lakshmana Prabu. 2019. Computer Applications in Drug Discovery and Development. Computer Applications in Drug Discovery and Development
1
46
.
Pascal Amoa Onguéné, Conrad V. Simoben, Ghislain W. Fotso, Kerstin Andrae-Marobela, Sami A. Khalid, Bonaventure T. Ngadjui, Luc Meva’a Mbaze & Fidele Ntie-Kang. (2018) In silico toxicity profiling of natural product compound libraries from African flora with anti-malarial and anti-HIV properties. Computational Biology and Chemistry 72, pages 136-149.
Crossref
Crossref
Daphnee Pushparajah, DFV Lewis & Costas Ioannides. (2017) Up-regulation of CYP1A1 and phase II enzymes by 5-ring isomeric polycyclic aromatic hydrocarbons in precision-cut rat hepatic slices: Importance of molecular shape. Toxicology in Vitro 40, pages 203-213.
Crossref
Crossref
Joachim Bucher, Stephan Riedmaier, Anke Schnabel, Katrin Marcus, Gabriele Vacun, Thomas S Weiss, Wolfgang E Thasler, Andreas K Nüssler, Ulrich M Zanger & Matthias Reuss. (2011) A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes. BMC Systems Biology 5:1.
Crossref
Crossref
Daphnee S. Pushparajah, Meera Umachandran, Tariq Nazir, Kathryn E. Plant, Nick Plant, David F.V. Lewis & Costas Ioannides. (2008) Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. Toxicology in Vitro 22:1, pages 128-145.
Crossref
Crossref
Andrej Bugrim, Tatiana Nikolskaya & Yuri Nikolsky. (2004) Early prediction of drug metabolism and toxicity: systems biology approach and modeling. Drug Discovery Today 9:3, pages 127-135.
Crossref
Crossref
Shahriar Haji-Momenian, Jayson M Rieger, Timothy L Macdonald & Milton L Brown. (2003) Comparative molecular field analysis and QSAR on substrates binding to cytochrome P450 2D6. Bioorganic & Medicinal Chemistry 11:24, pages 5545-5554.
Crossref
Crossref
Mark T. D. Cronin, John C. Dearden, John D. Walker & Andrew P. Worth. (2009) Quantitative structure‐activity relationships for human health effects: Commonalities with other endpoints. Environmental Toxicology and Chemistry 22:8, pages 1829-1843.
Crossref
Crossref
T.Wayne Schultz, Mark T.D. Cronin & Tatiana I. Netzeva. (2003) The present status of QSAR in toxicology. Journal of Molecular Structure: THEOCHEM 622:1-2, pages 23-38.
Crossref
Crossref
T.Wayne Schultz, Mark T.D. Cronin, John D. Walker & Aynur O. Aptula. (2003) Quantitative structure–activity relationships (QSARs) in toxicology: a historical perspective. Journal of Molecular Structure: THEOCHEM 622:1-2, pages 1-22.
Crossref
Crossref
David F. V. Lewis. (2003) Quantitative structure–activity relationships (QSARs) within the cytochrome P450 system: QSARs describing substrate binding, inhibition and induction of P450s. InflammoPharmacology 11:1, pages 43-73.
Crossref
Crossref
Mark T. D. Cronin. 2003. Modern Methods of Drug Discovery. Modern Methods of Drug Discovery
259
278
.
Michael J Sorich, Paul A Smith, Ross A McKinnon & John O Miners. (2002) Pharmacophore and quantitative structure activity relationship modelling of UDP-glucuronosyltransferase 1A1 (UGT1A1) substrates. Pharmacogenetics 12:8, pages 635-645.
Crossref
Crossref
. (2002) Chapter 7: Biokinetics. Alternatives to Laboratory Animals 30:1_suppl, pages 55-70.
Crossref
Crossref
D FV LewisM G Bird & M N Jacobs. (2016) Human carcinogens: an evaluation study via the COMPACT and HazardExpert procedures. Human & Experimental Toxicology 21:3, pages 115-122.
Crossref
Crossref
Jan Langowski & Anthony Long. (2002) Computer systems for the prediction of xenobiotic metabolism. Advanced Drug Delivery Reviews 54:3, pages 407-415.
Crossref
Crossref
David Lewis. 2001. Guide to Cytochromes P450. Guide to Cytochromes P450
164
210
.
David F.V. Lewis. (2000) On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics. Biochemical Pharmacology 60:3, pages 293-306.
Crossref
Crossref
David F.V. Lewis. (2000) Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles. Toxicology 144:1-3, pages 197-203.
Crossref
Crossref
T.W Schultz & J.R Seward. (2000) Health-effects related structure–toxicity relationships: a paradigm for the first decade of the new millennium. Science of The Total Environment 249:1-3, pages 73-84.
Crossref
Crossref
D.F.V. Lewis, P.J. Eddershaw, M. Dickins, M.H. Tarbit & P.S. Goldfarb. (1998) Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate. Chemico-Biological Interactions 115:3, pages 175-199.
Crossref
Crossref