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Research Article

Design of Intramolecularly Activated Prodrugs

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Pages 787-807 | Published online: 22 Sep 2008

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Chawanphat Muangnoi, Ponsiree Jithavech, Pahweenvaj Ratnatilaka Na Bhuket, Wiwat Supasena, Wisut Wichitnithad, Pasarapa Towiwat, Nuansri Niwattisaiwong, Ian S. Haworth & Pornchai Rojsitthisak. (2018) A curcumin-diglutaric acid conjugated prodrug with improved water solubility and antinociceptive properties compared to curcumin. Bioscience, Biotechnology, and Biochemistry 82:8, pages 1301-1308.
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Richard B. Silverman & Mark W. Holladay. 2014. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 423 468 .
Joachim A. Stellmach. (2009) The influences of the structure and activity of biologically active compounds on the assessment of inventive step. World Patent Information 31:3, pages 226-234.
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Bernard Testa & Stefanie D. Krämer. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:5, pages 591-684.
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Alain Trachsel, Jean-Yves de Saint Laumer, Olivier P. Haefliger & Andreas Herrmann. (2009) Parameters Influencing the Release of Tertiary Alcohols from the Surface of “Spherical” Dendrimers and “Linear” Stylomers by Neighbouring-Group-Assisted Hydrolysis of 2-Carbamoylbenzoates. Chemistry - A European Journal 15:12, pages 2846-2860.
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Rafik Karaman. (2009) A new mathematical equation relating activation energy to bond angle and distance: A key for understanding the role of acceleration in lactonization of the trimethyl lock system. Bioorganic Chemistry 37:1, pages 11-25.
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Yu Chen & Longqin Hu. (2008) Design of anticancer prodrugs for reductive activation. Medicinal Research Reviews 29:1, pages 29-64.
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Alain Trachsel, Alexandra Govoni, Jean‐Yves de Saint Laumer, Eric Frérot & Andreas Herrmann. (2008) Controlled Release of Volatile Secondary and Tertiary Alcohols by Neighboring Group Participation: Stepwise Cyclization and Re‐Opening of 2,2′‐Bis(carbamoyl)dibenzoates at Neutral pH. Chemistry & Biodiversity 5:12, pages 2621-2639.
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Bernard Testa. 2008. Drug Bioavailability. Drug Bioavailability 559 570 .
Paula Gomes, Nuno Vale & Rui Moreira. (2007) Cyclization-activated Prodrugs. Molecules 12:11, pages 2484-2506.
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Andreas Herrmann. (2007) Controlled Release of Volatiles under Mild Reaction Conditions: From Nature to Everyday Products. Angewandte Chemie International Edition 46:31, pages 5836-5863.
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Andreas Herrmann. (2007) Kontrollierte Freisetzung flüchtiger Verbindungen unter milden Reaktionsbedingungen: von der Natur zu Alltagsprodukten. Angewandte Chemie 119:31, pages 5938-5967.
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B. Testa. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 1009 1041 .
Richard B. Greenwald & Hong Zhao. 2007. Prodrugs. Prodrugs 283 338 .
Jeffrey P. Krise & Reza Oliyai. 2007. Prodrugs. Prodrugs 801 831 .
Graham S. Poindexter, Yadagiri Pendri, Lawrence B. Snyder, Joseph P. Yevich & Milind Deshpande. 2007. Kent and Riegel’s Handbook of Industrial Chemistry and Biotechnology. Kent and Riegel’s Handbook of Industrial Chemistry and Biotechnology 404 430 .
P. Jeschke & R. Nauen. 2005. Comprehensive Molecular Insect Science. Comprehensive Molecular Insect Science 53 105 .
Bernard Testa. (2004) Prodrug research: futile or fertile?. Biochemical Pharmacology 68:11, pages 2097-2106.
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Richard B. Silverman. 2004. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 497 557 .
Thorsten A. Kirschberg, Chris L. VanDeusen, Jonathan B. Rothbard, Michael Yang & Paul A. Wender. (2003) Arginine-Based Molecular Transporters:  The Synthesis and Chemical Evaluation of Releasable Taxol-Transporter Conjugates. Organic Letters 5:19, pages 3459-3462.
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Jean‐Yves de Saint Laumer, Eric Frérot & Andreas Herrmann. (2003) Controlled Release of Perfumery Alcohols by Neighboring‐Group Participation. Comparison of the Rate Constants for the Alkaline Hydrolysis of 2‐Acyl‐, 2‐(Hydroxymethyl)‐, and 2‐Carbamoylbenzoates. Helvetica Chimica Acta 86:8, pages 2871-2899.
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Joseph A. Fuselier, Lichun Sun, S.Nathaniel Woltering, William A. Murphy, Natalya Vasilevich & David H. Coy. (2003) An adjustable release rate linking strategy for cytotoxin–Peptide conjugates. Bioorganic & Medicinal Chemistry Letters 13:5, pages 799-803.
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Donald J. AbrahamBernard Testa & William Soine. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 431 498 .
Richard B. Greenwald, Yun H. Choe, Jeffrey McGuire & Charles D. Conover. (2003) Effective drug delivery by PEGylated drug conjugates. Advanced Drug Delivery Reviews 55:2, pages 217-250.
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James A. Kent. 2003. Riegel's Handbook of Industrial Chemistry. Riegel's Handbook of Industrial Chemistry 1073 1097 .
R.B Greenwald. (2001) PEG drugs: an overview. Journal of Controlled Release 74:1-3, pages 159-171.
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Richard B. Greenwald, Yun H. Choe, Charles D. Conover, Kwok Shum, Dechun Wu & Maksim Royzen. (2000) Drug Delivery Systems Based on Trimethyl Lock Lactonization:  Poly(ethylene glycol) Prodrugs of Amino-Containing Compounds. Journal of Medicinal Chemistry 43:3, pages 475-487.
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