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Drug Metabolism Reviews Volume 30, 1998 - Issue 4
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Research Article

Metabolism of Haloperidol and Its Tetrahydropyridine Dehydration Product HPTP

Etsuko Usuki Peters Center for the Study of Parkinson's Disease Departments of Chemistry, VA-MD Regional College of Veterinary Medicine Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061-0212; Peters Center for the Study of Parkinson's Disease Departments of Biomedical Sciences and Pathobiology, VA-MD Regional College of Veterinary Medicine Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061-0212
,
Cornelis J. Van Der Schyf Peters Center for the Study of Parkinson's Disease Departments of Chemistry, VA-MD Regional College of Veterinary Medicine Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061-0212; Peters Center for the Study of Parkinson's Disease Departments of Biomedical Sciences and Pathobiology, VA-MD Regional College of Veterinary Medicine Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061-0212
&
Neal Castagnoli Peters Center for the Study of Parkinson's Disease Departments of Chemistry, VA-MD Regional College of Veterinary Medicine Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061-0212; Peters Center for the Study of Parkinson's Disease Departments of Biomedical Sciences and Pathobiology, VA-MD Regional College of Veterinary Medicine Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061-0212
Pages 809-826 | Published online: 22 Sep 2008

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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Etsuko Usuki, JeffreyR. Bloomquist, Ethan Freeborn, Kay Castagnoli, CornelisJ. Van der Schyf & Neal Castagnoli$suffix/text()$suffix/text(). (2002) Metabolic Studies on Haloperidol and Its Tetrahydropyridinyl Dehydration Product (HPTP) in C57BL/6 Mouse Brain Preparations. Neurotoxicity Research 4:1, pages 51-58.
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Articles from other publishers (11)

Nicholas A. Meanwell & Olivier Loiseleur. (2022) Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 1. Journal of Agricultural and Food Chemistry 70:36, pages 10942-10971.
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Francesca Serena Abatematteo, Mauro Niso, Marialessandra Contino, Marcello Leopoldo & Carmen Abate. (2021) Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives. International Journal of Molecular Sciences 22:12, pages 6359.
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Slobodan P. Rendic & F. Peter Guengerich. (2021) Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology 95:2, pages 395-472.
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Ji-Young ParkJae-Gook Shin. (2016) Development and validation of a HPLC-UV method for 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in humans: providing in vivo evidence of CYP3A4-mediated CPHP formation. Translational and Clinical Pharmacology 24:3, pages 147.
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Donald J. AbrahamJulian Blagg. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 301 334 .
Carl D. Davis & Umesh M. Hanumegowda. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 68 .
Carl D. Davis & Umesh M. Hanumegowda. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook 559 628 .
Masakazu Hanagama, Hiromasa Inoue, Munechika Kamiya, Kotaro Shinone & Masayuki Nata. (2008) Gene expression on liver toxicity induced by administration of haloperidol in rats with severe fatty liver. Legal Medicine 10:4, pages 177-184.
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Makoto Kawai, Hiroshi Nakamura, Isao Sakurada, Hirohisa Shimokawa, Hirotaka Tanaka, Miyako Matsumizu, Kazuo Ando, Kazunari Hattori, Atsuko Ohta, Seiji Nukui, Atsushi Omura & Mitsuhiro Kawamura. (2007) Discovery of novel and orally active NR2B-selective N-methyl-d-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity. Bioorganic & Medicinal Chemistry Letters 17:20, pages 5533-5536.
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Enrique J. Cobos, Esperanza del Pozo & José M. Baeyens. (2007) Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells. Journal of Neurochemistry 102:3, pages 812-825.
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Lodewyk J. Mienie, Jacobus J. Bergh, Jeffrey R. Bloomquist, Neal CastagnoliJr.Jr., Stefanus J. Steyn & Cornelis J. Van der Schyf. (1999) p-Fluorophenylglycine in the urine of baboons treated with HPTP, the tetrahydropyridine analog of haloperidol. Life Sciences 65:5, pages 535-542.
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