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Hemoglobin
international journal for hemoglobin research
Volume 4, 1980 - Issue 1
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Original Article

Molecular Stability and Function of Hb C-Harlem

Kazuhiko Adachi The Children's Hospital of Philadelphia Department of Pediatrics and the Department of Biochemistry and Biophysics, University of Pennsylvania Philadelphia, Pennsylvania, 19104
,
Thomas R. Kinney The Children's Hospital of Philadelphia Department of Pediatrics and the Department of Biochemistry and Biophysics, University of Pennsylvania Philadelphia, Pennsylvania, 19104
,
Elias Schwartz The Children's Hospital of Philadelphia Department of Pediatrics and the Department of Biochemistry and Biophysics, University of Pennsylvania Philadelphia, Pennsylvania, 19104
&
Toshio Asakura The Children's Hospital of Philadelphia Department of Pediatrics and the Department of Biochemistry and Biophysics, University of Pennsylvania Philadelphia, Pennsylvania, 19104
Pages 1-26 | Received 15 Mar 1979, Accepted 08 Nov 1979, Published online: 07 Jul 2009

Citations (15)

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Read on this site (6)

K. Adachi, S. Surrey, H. Tamary, J. Kim, H. S. Eck, E. Rappaport & K. Ohene-Frempong. (1993) HB Shelby [β131(H9)GLN→LYS] in Association with HB S [β6(A3)GLU→VAL]: Characterization, Stability, and Effects on HB S Polymerization. Hemoglobin 17:4, pages 329-343.
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Y. Enoki, Y. Ohga, K. Furukawa, A. Takaya, S. Sakata, H. Kohzuki, S. Shimizu & T. Tsujii. (1989) HB hope, β136(H14)Gly→Asp, in a Diabetic Japanese Female and its Functional Characterization. Hemoglobin 13:1, pages 17-32.
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Yoko Tanaka, John F. Kelleher, Elias Schwartz, Toshio Asakura, Joan Shelton, J. Roger Shelton & Walter A. Schroeder. (1985) Oxygen Binding and Stability Properties of Hb Santa Ana (β88 Leu→Pro). Hemoglobin 9:2, pages 157-169.
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Hiroko Kosugi, Alan S. Weinstein, Kiyomi Kikugawa, Toshio Asakura & Walter A. Schroeder. (1983) Characterization and Properties of Hb York (β146 HIS-PRO). Hemoglobin 7:3, pages 205-226.
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John W. Bender, Kazuhiko Adachi & Toshio Asakura. (1981) Precipitation of Oxyhemoglobins A and S by Isopropanol. Hemoglobin 5:5, pages 463-474.
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M. L. North, J. Thillet & J. Rosa. (1981) Effect of Some physical Features and of Amino acid Substitutions on the Mechanical Precipitation of Hemoglobin. Hemoglobin 5:4, pages 379-390.
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Articles from other publishers (9)

Kazuhiko Adachi, Min Ding, Suzanne Wehrli, Konda S. Reddy, Saul Surrey & Kazumi Horiuchi. (2003) Effects of Different β73 Amino Acids on Formation of 14-Stranded Fibers of Hb S versus Double-Stranded Crystals of Hb C-Harlem. Biochemistry 42:15, pages 4476-4484.
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Maria Ivanova, Ravi Jasuja, Lada Krasnosselskaia, Robert Josephs, Zhiping Wang, Min Ding, Kazumi Horiuchi, Kazuhiko Adachi & Frank A Ferrone. (2001) Flexibility and nucleation in sickle hemoglobin 1 1Edited by M. F. Moody. Journal of Molecular Biology 314:4, pages 851-861.
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K. Adachi, P. Konitzer, C.G. Paulraj & S. Surrey. (1994) Role of Leu-beta 88 in the hydrophobic acceptor pocket for Val-beta 6 during hemoglobin S polymerization. Journal of Biological Chemistry 269:26, pages 17477-17480.
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K. Adachi, J.Y. Kim, P. Konitzer, T. Asakura, B. Saviola & S. Surrey. (1993) Effects of β6 amino acid hydrophobicity on stability and solubility of hemoglobin tetramers. FEBS Letters 315:1, pages 47-50.
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Giancarlo Falcioni, Francesco Grelloni, Enrico Bertoli, Leonardo Felici & Giovanni Valentino Coppa. (1991) Influence of splenectomy on the properties of erythrocytes with hemoglobin Volga disease. Clinica Chimica Acta 196:2-3, pages 153-158.
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K Adachi, J Kim, R Travitz, T Harano & T Asakura. (1987) Effect of amino acid at the beta 6 position on surface hydrophobicity, stability, solubility, and the kinetics of polymerization of hemoglobin. Comparisons among Hb A (Glu beta 6), Hb C (Lys beta 6), Hb Machida (Gln beta 6), and Hb S (Val beta 6).. Journal of Biological Chemistry 262:27, pages 12920-12925.
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K. Adachi, H. Vonk, M.P. Reilly, H. Adachi, W.A. Schroeder, E. Schwartz & T. Asakura. (1984) Relationship between tetramer-dimer assembly and the stability of Hb Malmö (α2β297Gln). Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 790:2, pages 132-140.
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Kazuhiko Adachi, Kiyomi Kikugawa & Toshio Asakura. (1983) Aggregation of hemoglobin S modified by bifunctional imidoesters. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 742:3, pages 597-606.
Crossref
Kazuhiko Adachi & Toshio Asakura. (1980) Polymerization of deoxyhemoglobin CHarlem (?6 Glu ? Val, ?73 Asp ? Asn). Journal of Molecular Biology 144:4, pages 467-480.
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