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Hemoglobin
international journal for hemoglobin research
Volume 7, 1983 - Issue 2
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Original Article

Gene Deletion as the Molecular Basis for the Kenya-Gγ-Hpfh Condition

P. J. Ojwang Department of Human Pathology, Faculty of Medicine, University of Nairobi, Nairobi, Kenya
,
T. Nakatsuji Laboratory of Protein Chemistry Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA
,
M. B. Gardiner Laboratory of Protein Chemistry Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA
,
A. L. Reese Laboratory of Protein Chemistry Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA
,
J. G. Gilman Laboratory of Protein Chemistry Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA
&
T. H. J. Huisman Laboratory of Protein Chemistry Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA
Pages 115-123 | Received 06 Jan 1983, Accepted 07 Feb 1983, Published online: 07 Jul 2009

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Dilip K. Rai, Gunvor Alvelius & Britta Landin. (2002) IDENTIFICATION OF Hb KENYA (Aγ81Leu-β86Ala) BY ELECTROSPRAY MASS SPECTROMETRY. Hemoglobin 26:1, pages 71-75.
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Georgi D. Efremov. (2001) FORTY-FOUR YEARS (1955–1999) DEVOTED TO HEMOGLOBIN RESEARCH: TITUS H. J. HUISMAN (1923–1999). Hemoglobin 25:2, pages 125-168.
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T. H. J. Huisman. (1997) Compound Heterozygosity for Hb S and the Hybrid Hbs Lepore, P-Nilotic, and Kenya; Comparison of Hematological and Hemoglobin Composition Data. Hemoglobin 21:3, pages 249-257.
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E. George, H-J. Li, Y-J. Fei, A. L. Reese, E. Baysal, B. Cepreganova, J. B. Wilson, L-H. Gu, J. F. Nechtman, T. A. Stoming, J-C. Liu, J. F. Codrington & T. H. J. Huisman. (1992) Types of Thalassemia Among Patients Attending a Large University Clinic in Kuala Lumpur, Malaysia. Hemoglobin 16:1-2, pages 51-66.
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Marie Frudel, Jeanne Magram, Lauren Bruckner & Frank Costantini. (1987) Upstream Gℽ-Globin and Downstream β-Globin Sequences Required for Stage-Specific Expression in Transgenic Mice. Molecular and Cellular Biology 7:11, pages 4024-4029.
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T. H. J. Huisman, M. G. Headlee, J. B. Wilson, H. Lam, S. E. N. Johnson & B. B. Webber. (1984) HB Wayne, the Frameshift Variant with Extended α Chains Observed in a Caucasian Family from Alabama. Hemoglobin 8:1, pages 1-15.
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Articles from other publishers (14)

Sarah K. TopferRuopeng FengPeng Huang, Lana C. Ly, Gabriella E. MartynGerd A. Blobel, Mitchell J. WeissKate G. R. Quinlan & Merlin Crossley. (2022) Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression. Blood 139:14, pages 2107-2118.
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John Chapin & Patricia J. Giardina. 2018. Hematology. Hematology 546 570.e10 .
Lin YeJiaming WangYuting TanAshley I. Beyer, Fei XieMarcus O. Muench & Yuet Wai Kan. (2016) Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia. Proceedings of the National Academy of Sciences 113:38, pages 10661-10665.
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George P. Patrinos & Stylianos E. Antonarakis. 2010. Vogel and Motulsky's Human Genetics. Vogel and Motulsky's Human Genetics 365 401 .
Joseph Borg, Marianthi Georgitsi, Vassiliki Aleporou-Marinou, Panagoula Kollia & George P. Patrinos. (2009) Genetic recombination as a major cause of mutagenesis in the human globin gene clusters. Clinical Biochemistry 42:18, pages 1839-1850.
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Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs & David J. WeatherallSwee Lay Thein & William G. Wood. 2010. Disorders of Hemoglobin. Disorders of Hemoglobin 323 356 .
Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs & David J. Weatherall. 2010. Disorders of Hemoglobin. Disorders of Hemoglobin 321 322 .
Laura Manca & Bruno Masala. (2008) Disorders of the synthesis of human fetal hemoglobin. IUBMB Life 60:2, pages 94-111.
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D.J. Weatherall & J.B. Clegg. 2001. The Thalassaemia Syndromes. The Thalassaemia Syndromes 733 821 .
W. E. Rodriguez Romero, M. Castillo, M. A. Chaves, G. F. Saenz, L. -H. Gu, J. B. Wilson, E. Baysal, N. S. Smetanina, J. Y. Leonova & T. H. J. Huisman. (1996) Hb Costa Rica or α2β277(EF1)His→Arg: The first example of a somatic cell mutation in a globin gene. Human Genetics 97:6, pages 829-833.
Crossref
John S. Waye, David H. K. Chui, Shi‐Ping Cai, Barry Eng & William H. Francombe. (2006) Clinical course and molecular characterization of a compound heterozygote for sickle hemoglobin and hemoglobin kenya. American Journal of Hematology 41:4, pages 289-291.
Crossref
Jacques A. Bollekens & Bernard G. Forget. (1991) δβ Thalassemia and Hereditary Persistence of Fetal Hemoglobin. Hematology/Oncology Clinics of North America 5:3, pages 399-422.
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R.D. Nicholls, N. Fischel-Ghodsian & D.R. Higgs. (1987) Recombination at the human α-globin gene cluster: Sequence features and topological constraints. Cell 49:3, pages 369-378.
Crossref
Francis S. Collins & Sherman M. Weissman. 1984. Progress in Nucleic Acid Research and Molecular Biology Volume 31. Progress in Nucleic Acid Research and Molecular Biology Volume 31 315 465 .

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