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Hemoglobin
international journal for hemoglobin research
Volume 7, 1983 - Issue 4
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Original Article

Two Unstable Hemoglobins in One Individual: Hb Atlanta (β75 Leu→Pro) and Hb Coventry (β141 Leu deleted)

S. O. Brennan Molecular Pathology Laboratory, Pathology Dept., Christchurch Hospital, Christchurch, New Zealand
,
D. Williamson Molecular Pathology Laboratory, Pathology Dept., Christchurch Hospital, Christchurch, New Zealand
,
W. A. Symmans Hamilton Medical Laboratory, Hamilton, New Zealand
&
R. W. Carrell Molecular Pathology Laboratory, Pathology Dept., Christchurch Hospital, Christchurch, New Zealand
Pages 303-312 | Received 08 Feb 1983, Accepted 05 Apr 1983, Published online: 07 Jul 2009

Citations (7)

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Read on this site (4)

Philippe Lacan, Martine Aubry, Nicole Couprie & Alain Francina. (2007) Two New β0-Thalassemic Mutations: A Deletion (−CC) at Codon 142 or Overlapping Codons 142-143, and an Insertion (+T) at Codon 45 or Overlapping Codons 44-45/45-46 of the β-Globin Gene. Hemoglobin 31:2, pages 159-165.
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S. O. Brennan, J. G. Shaw, P. M. George & T. H. J. Huislpan. (1993) Posttranslational Modification of β141 LEU Associated with the β75(E19)Leu→pro Mutation in HB Atlanta. Hemoglobin 17:1, pages 1-7.
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Y. Ohba, K. Yamaoto, Y. Hattori, R. Kawata & T. Miyaji. (1987) Hyperunstable Hemoglobin Toyama [α2136(H19)LEU→ARGβ2]: Detection and Identification by in Vitro Biosynthesis with Radioactive Amino Acids. Hemoglobin 11:6, pages 539-556.
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S. O. Brennan, D. Williamson, W. A. Symmans & R. W. Carrell. (1986) Two de novo mutations in one β globin chain: Hemoglobin atlanta-coventry, β75 Leu→Pro and β141 Leu deleted. Hemoglobin 10:3, pages 225-237.
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Articles from other publishers (3)

J.B. Wilson, S.O. Brennan, J. Allen, J.G. Shaw, L.-H. Gu & T.H.J. Huisman. (1993) The Mγ chain of human fetal hemoglobin is an Aγ chain with an in vitro modification of γ141 leucine to hydroxyleucine. Journal of Chromatography B: Biomedical Sciences and Applications 617:1, pages 37-42.
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Stephen O. Brennan, John Shaw, John Allen & Peter M. George. (2008) β141 Leu is not deleted in the unstable haemoglobin Atlanta‐Coventry but is replaced by a novel amino acid of mass 129 daltons. British Journal of Haematology 81:1, pages 99-103.
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Peter M. George, Timothy Myles, David Williamson, Russell Higuchi, W. Ashley Symmans & Stephen O. Brennan. (2008) A family with haemolytic anaemia and three β‐globins: the deletion in haemoglobin Atlanta‐Coventry (β75 Leu→Pro, 141 Leu deleted) is not present at the nucleotide level. British Journal of Haematology 81:1, pages 93-98.
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