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Hemoglobin
international journal for hemoglobin research
Volume 8, 1984 - Issue 1
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Original Article

Hematological Phenotype of the Double Heterozygous State for Alpha and Beta Thalassemia

C. Rosatelli Institute of Clinic and Biology of Developmental Age University of Cagliari, Sardinia, Italy
,
A. M. Falchi Institute of Clinic and Biology of Developmental Age University of Cagliari, Sardinia, Italy
,
M. T. Scalas Institute of Clinic and Biology of Developmental Age University of Cagliari, Sardinia, Italy
,
T. Tuveri Institute of Clinic and Biology of Developmental Age University of Cagliari, Sardinia, Italy
,
M. Furbetta Institute of Clinic and Biology of Developmental Age University of Cagliari, Sardinia, Italy
&
A. Cao Institute of Clinic and Biology of Developmental Age University of Cagliari, Sardinia, Italy
Pages 25-35 | Received 14 Jun 1983, Accepted 30 Sep 1983, Published online: 07 Jul 2009

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Fan Jiang, Gui-Lan Chen, Jian Li, Jian-Ying Zhou, Can Liao & Dong-Zhi Li. (2018) Analysis of the Genotypes in a Chinese Population with Increased Hb A2 and Low Hematological Indices. Hemoglobin 42:3, pages 154-158.
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Y. E. Hsia, J. Yuen, J. A. Hunt, P. Rattamanasay, J. Hall, N. Takaesu, E. A. B. Titus, J. Fujita & C. A. Ford. (1988) The Different Types of α-Thalassemia: Practical and Genetic Aspects. Hemoglobin 12:5-6, pages 465-484.
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Articles from other publishers (34)

Stacy Colaco, Roshan Colah & Anita Nadkarni. (2022) Significance of borderline HbA2 levels in β thalassemia carrier screening. Scientific Reports 12:1.
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Shir Ying Lee, Eng Soo Yap, Elaine YP Lee, Jia Hui Goh, Te Chih Liu & Christina Yip. (2019) Evaluation of Thalassaemia Screening Tests in the Antenatal and Non-Antenatal Populations in Singapore. Annals of the Academy of Medicine, Singapore 48:1, pages 5-15.
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John Chapin & Patricia J. Giardina. 2018. Hematology. Hematology 546 570.e10 .
Bridget S. Penman, Sunetra Gupta & David J. Weatherall. (2014) Epistasis and the sensitivity of phenotypic screens for beta thalassaemia. British Journal of Haematology 169:1, pages 117-128.
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Jian Li, Xing-Mei Xie, Can Liao & Dong-Zhi Li. (2014) Co-inheritance of α-thalassaemia and β-thalassaemia in a prenatal screening population in mainland China. Journal of Medical Screening 21:4, pages 167-171.
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Thanusak Tatu, Tiemjan Kiewkarnkha, Surakit Khuntarak, Sakdinan Khamrin, Surasit Suwannasin & Watchara Kasinrerk. (2012) Screening for co-existence of α-thalassemia in β-thalassemia and in HbE heterozygotes via an enzyme-linked immunosorbent assay for Hb Bart’s and embryonic ζ-globin chain. International Journal of Hematology 95:4, pages 386-393.
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Murat O. Arcasoy & Patrick G. Gallagher. 2010. Molecular Pathology of Hematolymphoid Diseases. Molecular Pathology of Hematolymphoid Diseases 473 497 .
Jin Ai Mary Anne Tan, Juan Loong Kok, Kim Lian Tan, Yong Chui Wee & Elizabeth George. (2009) Thalassemia intermedia in HbH-CS disease with compound heterozygosity for .BETA.-thalassemia: Challenges in hemoglobin analysis and clinical diagnosis. Genes & Genetic Systems 84:1, pages 67-71.
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Dong‐Zhi Li & Can Liao. (2008) A case of transfusion‐dependent nondeletional Hb H disease undiagnosed during prenatal screening for thalassemia. Prenatal Diagnosis 28:2, pages 165-166.
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Antonio Cao, M. Cristina Rosatelli & Renzo Galanello. 2007. Ciba Foundation Symposium 197 ‐ Variation in the Human Genome. Ciba Foundation Symposium 197 ‐ Variation in the Human Genome 137 155 .
C. Liao, X.-M. Xie & D.-Z. Li. (2007) Two cases of homozygous α0-thalassemia diagnosed prenatally in pregnancies at risk for β-thalassemia in China. Ultrasound in Obstetrics and Gynecology 29:4, pages 474-475.
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Sarita Agarwal & Nikhil Moorchung. (2005) Modifier Genes and Oligogenic Disease. Journal of Nippon Medical School 72:6, pages 326-334.
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Douglas R. Higgs. (2004) Ham-Wasserman Lecture. Hematology 2004:1, pages 1-13.
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Chad Garner, Tracy K. Dew, Roy Sherwood, David Rees & Swee Lay Thein. (2003) Heterocellular hereditary persistence of fetal haemoglobin affects the haematological parameters of β-thalassaemia trait. British Journal of Haematology 123:2, pages 353-358.
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Antonio Cao, Maria Cristina Rosatelli, Giovanni Monni & Renzo Galanello. (2002) Screening for thalassemia. Obstetrics and Gynecology Clinics of North America 29:2, pages 305-328.
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Antonio Cao. (2002) Carrier screening and genetic counselling in β-thalassemia. International Journal of Hematology 76:S2, pages 105-113.
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D.J. Weatherall & J.B. Clegg. 2001. The Thalassaemia Syndromes. The Thalassaemia Syndromes 733 821 .
Antonio Cao & Paolo Moi. (2000) Genetic Modifying Factors in β-Thalassemia. cclm 38:2, pages 123-132.
Crossref
Antonio Cao, Renzo Galanello & M. Cristina Rosatelli. (1998) 8 Prenatal diagnosis and screening of the haemoglobinopathies. Baillière's Clinical Haematology 11:1, pages 215-238.
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A. Cao, R. Galanello & M.C. Rosatelli. (1994) Genotype-phenotype correlations in β-thalassemias. Blood Reviews 8:1, pages 1-12.
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Antonio Cao & Maria Cristina Rosatelli. (1993) 9 Screening and prenatal diagnosis of the haemoglobinopathies. Baillière's Clinical Haematology 6:1, pages 263-286.
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C. Rosatelli, G. B. Leoni, T. Tuveri, M. T. Scalas, A. Mosca, R. Galanello, D. Gasperini & A. Cao. (2006) Heterozygous β‐thalassemia: Relationship between the hematological phenotype and the type of β‐thalassemia mutation. American Journal of Hematology 39:1, pages 1-4.
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M. PIRASTU, M. S. RISTALDI, G. LOUDIANOS, S. MURRU, G. V. SCIARRATTA, M. I. PARODI, D. LEONE, S. AGOSTI & A. CAO. (1990) Molecular Analysis of Atypical ?-Thalassemia Heterozygotes. Annals of the New York Academy of Sciences 612:1 Sixth Cooley', pages 90-97.
Crossref
Beverly R. Akerman, T. Mary Fujiwara, Gerald A. Lancaster, Kenneth Morgan & Charles R. Scriver. (1990) Identification of deletion and triple α-globin gene haplotypes in the montreal β-thalassemia screening program: Implications for genetic medicine. American Journal of Medical Genetics 36:1, pages 76-84.
Crossref
C. R. Scriver. (1989) The salience of Garrod's ‘molecular groupings’ and ‘Inborn Factors in Disease’. Journal of Inherited Metabolic Disease 12:S1, pages 9-24.
Crossref
C. R. Scriver. 1989. Studies in Inherited Metabolic Disease. Studies in Inherited Metabolic Disease 9 24 .
P. Vyas, D. R. Higgs, D. J. Weatherall, D. Dunn, B. E. Serjeant & G. R. Serjeant. (1988) The interaction of alpha thalassaemia and sickle cell–beta° thalassaemia. British Journal of Haematology 70:4, pages 449-454.
Crossref
P. Vyas, D. R. Higgs, D. J. Weatherall, D. Dunn, B. E. Serjeant & G. R. Serjeant. (2008) The interaction of alpha thalassaemia and sickle cell–beta° thalassaemia. British Journal of Haematology 70:4, pages 449-454.
Crossref
Renzo Galanello, Elisabetta Paglietti, Maria A. Melis, Maria G. Crobu, Maria Addis, Paolo Moi & Antonio Cao. (2006) Interaction of heterozygous β o ‐thalassemia with single functional α‐globin gene . American Journal of Hematology 29:2, pages 63-66.
Crossref
R. Galanello, M. E. Paglietti, M. Addis, M. A. Melis, T. Tuveri, M. Furbetta & A. Cao. (2008) Pitfalls in genetic counselling for β-thalassemia: an individual with 4 different thalassemia mutations. Clinical Genetics 33:3, pages 151-155.
Crossref
A. Cao. (1987) Results of programmes for antenatal detection of thalassemia in reducing the incidence of the disorder. Blood Reviews 1:3, pages 169-176.
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C Rosatelli, L Maccioni, M T Scalas & A Cao. (1986) Pitfalls in prenatal diagnosis of beta thalassaemia.. Journal of Medical Genetics 23:5, pages 456-458.
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D.J. Weatherall. (1985) Prenatal Diagnosis of Inherited Blood Diseases. Clinics in Haematology 14:3, pages 747-774.
Crossref
T. Harano, A. L. Reese, R. Ryan, B. L. Abraham & T. H. J. Huisman. (2008) Five haplotypes in Black β‐thalassaemia heterozygotes: three are associated with high and two with low G γ values in fetal haemoglobin . British Journal of Haematology 59:2, pages 333-342.
Crossref

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