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Hemoglobin
international journal for hemoglobin research
Volume 12, 1988 - Issue 5-6
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Original Article

Selection of Hydroxypyridin-4-Ones for the Treatment of Iron Overload Using In Vitro and In Vivo Models

E. R. Huehns University College London 98 affnies Mews, London, WCIE 6HX
,
J. B. Porter University College London 98 affnies Mews, London, WCIE 6HX
&
R. C. Hider King's College, Manresa Road, London, SW3 6LX
Pages 593-600 | Received 22 Dec 1987, Accepted 01 Jun 1988, Published online: 07 Jul 2009

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Read on this site (3)

MarkM. Jones. (1992) Newer Chelating Agents for in Vivo Toxic Metal Mobilization. Comments on Inorganic Chemistry 13:2, pages 91-110.
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MarkM. Jones. (1991) The Design of Therapeutic Chelating Agents. Journal of Coordination Chemistry 23:1-4, pages 187-200.
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Mark M. Jones. (1991) New Developments in Therapeutic Chelating Agents as Antidotes for Metal Poisoning. Critical Reviews in Toxicology 21:3, pages 209-233.
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Articles from other publishers (23)

George J. Kontoghiorghes. (2023) Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects. International Journal of Molecular Sciences 24:5, pages 4970.
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Shailza Sharma, Minati Baral & B. K. Kanungo. (2022) Recent advances in therapeutical applications of the versatile hydroxypyridinone chelators. Journal of Inclusion Phenomena and Macrocyclic Chemistry 102:3-4, pages 169-200.
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Samie Salehi, Amir Shokooh Saljooghi & Mohammad Izadyar. (2016) A theoretical study on the electronic structures and equilibrium constants evaluation of Deferasirox iron complexes. Computational Biology and Chemistry 64, pages 99-106.
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Yu-Lin Chen, Dave J. Barlow, Xiao-Le Kong, Yong-Min Ma & Robert C. Hider. (2012) Prediction of 3-hydroxypyridin-4-one (HPO) log K1 values for Fe(iii). Dalton Transactions 41:35, pages 10784.
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Yu-Lin Chen, Dave J. Barlow, Xiao-Le Kong, Yong-Min Ma & Robert C. Hider. (2012) Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pKa values. Dalton Transactions 41:21, pages 6549.
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John Burgess & Maria Rangel. 2008. 167 243 .
A.E.R. Kartikasari, N.A. Georgiou & J.J.M. Marx. 2004. Functional Foods, Cardiovascular Disease and Diabetes. Functional Foods, Cardiovascular Disease and Diabetes 99 125 .
Arthur E Martell, R.J Motekaitis, Y Sun, R Ma, M.J Welch & T Pajeau. (1999) New chelating agents suitable for the treatment of iron overload. Inorganica Chimica Acta 291:1-2, pages 238-246.
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Paul Baret, Virginie Beaujolais, Claude Béguin, Didier Gaude, Jean-Louis Pierre & Guy Serratrice. (1998) Towards New Iron(III) Chelators: Synthesis and Complexing Ability of a Water-Soluble Tripodal Ligand Based on 2,2′-Dihydroxybiphenyl Subunits. European Journal of Inorganic Chemistry 1998:5, pages 613-619.
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Arthur E. Martell & Robert D. HancockArthur E. Martell & Robert D. Hancock. 1996. Metal Complexes in Aqueous Solutions. Metal Complexes in Aqueous Solutions 149 197 .
D. M. Templeton. 1995. Toxicology of Metals. Toxicology of Metals 305 331 .
Chaim Hershko. (1994) 11 Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators. Baillière's Clinical Haematology 7:4, pages 965-1000.
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Christopher D. Saudek & Samuel Charache. (1992) 5 Haemochromatosis and diabetes. Baillière's Clinical Endocrinology and Metabolism 6:4, pages 807-817.
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C. Hershko, V.R. Gordeuk, G.M. Brittenham, P.E. Thuma, E.N. Theanacho, D.T. Spira, R.C. Hider & T.E.A. Peto. (1992) The antimalarial effect of iron chelators: Studies in animal models and in humans with mild falciparum malaria. Journal of Inorganic Biochemistry 47:1, pages 267-277.
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Gaoyi Xiao, Dick van der Helm, Robert C. Hider & Paul S. Dobbin. (1992) Structure–stability relationships of 3-hydroxypyridin-4-one complexes. J. Chem. Soc., Dalton Trans.:22, pages 3265-3271.
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John M. Skjaerlund, Gary S. Krause, Deborah M. Feldman, Brian J. O'Neil & Blaine C. White. (1991) The effect of EMHP on post-cardiac arrest survival of rats. Resuscitation 22:2, pages 139-149.
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Simonetta Stefanini, Emilia Chiancone, Stefano Cavallo, Victoria Saez, Adrian D. Hall & Robert C. Hider. (1991) The interaction of hydroxypyridinones with human serum transferrin and ovotransferrin. Journal of Inorganic Biochemistry 44:1, pages 27-37.
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GEORGE J. KONTOGHIORGHES. (1990) Design, Properties, and Effective Use of the Oral Chelator L1 and Other.. Annals of the New York Academy of Sciences 612:1 Sixth Cooley', pages 339-350.
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R. C. HIDER, S. SINGH, J. B. PORTER & E. R. HUEHNS. (1990) The Development of Hydroxypyridin-4-ones as Orally Active Iron Chelators. Annals of the New York Academy of Sciences 612:1 Sixth Cooley', pages 327-338.
Crossref
John Porter. (2009) Oral iron chelators: Prospects for future development. European Journal of Haematology 43:4, pages 271-285.
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. (1989) Oral Iron Chelators. The Lancet 334:8670, pages 1016-1017.
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J.B. Porter, K.P. Hoyes, R. Abeysinghe, E.R. Huehns & R.C. Hider. (1989) ANIMAL TOXICOLOGY OF IRON CHELATOR L1. The Lancet 334:8655, pages 156.
Crossref
J.B. Porter, E.R. Huehns & R.C. Hider. (1989) 2 The development of iron chelating drugs. Baillière's Clinical Haematology 2:2, pages 257-292.
Crossref

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