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Hemoglobin
international journal for hemoglobin research
Volume 34, 2010 - Issue 3
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Research Article

Iron Chelation Therapy in Hereditary Hemochromatosis and Thalassemia Intermedia: Regulatory and Non Regulatory Mechanisms of Increased Iron Absorption

George J. Kontoghiorghes Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, CyprusCorrespondence[email protected]
,
Aspasia Spyrou Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus
&
Annita Kolnagou Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus
Pages 251-264 | Published online: 04 Jun 2010

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Christina N Kontoghiorghe & George J Kontoghiorghes. (2016) Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes. Drug Design, Development and Therapy 10, pages 465-481.
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Herminio López-Escribano, Joana F. Ferragut, Maria M. Parera, Pilar Guix, José A. Castro, M. Misericòrdia Ramon & Antònia Picornell. (2012) Effect of Co-Inheritance of β-Thalassemia and Hemochromatosis Mutations on Iron Overload. Hemoglobin 36:1, pages 85-92.
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George J. Kontoghiorghes. (2011) A Record Of 1320 Suspect, Deferasirox-Related, Patient Deaths Reported In 2009: Insufficient Toxicity Testing, Low Efficacy And Lack Of Transparency May Endanger The Lives Of Iron Loaded Patients. Hemoglobin 35:3, pages 301-311.
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H.P. Nick. (2011) Iron Chelation Therapy in Hereditary Hemochromatosis and Thalassemia Intermedia: Regulatory and Non Regulatory Mechanisms of Increased Iron Absorption [Kontoghiorghes GJ, Spyrou A, Kolganou A. Hemoglobin. 2010;34(3); 251–264]. Hemoglobin 35:2, pages 175-179.
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Articles from other publishers (23)

George J. Kontoghiorghes. (2023) Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications. International Journal of Molecular Sciences 24:16, pages 12928.
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George J. Kontoghiorghes. (2023) Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects. International Journal of Molecular Sciences 24:5, pages 4970.
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George J. Kontoghiorghes. (2022) New Iron Metabolic Pathways and Chelation Targeting Strategies Affecting the Treatment of All Types and Stages of Cancer. International Journal of Molecular Sciences 23:22, pages 13990.
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Shan Wei, Ren-Gang Zhang & Zheng-Yu Wang. (2022) Deferoxamine/magnesium modified β-tricalcium phosphate promotes the bone regeneration in osteoporotic rats. Journal of Biomaterials Applications 37:5, pages 838-849.
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George J. Kontoghiorghes. (2022) Questioning Established Theories and Treatment Methods Related to Iron and Other Metal Metabolic Changes, Affecting All Major Diseases and Billions of Patients. International Journal of Molecular Sciences 23:3, pages 1364.
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Helena M.R. Gonçalves, Isabel S. Tavares, Susana A.F. Neves, Rui Fontes & Abel J. Duarte. (2022) Turn-on, photostable, nontoxic and specific, iron(II) sensor. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 265, pages 120380.
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Xianzhen Dong, Ping Wu, Lesan Yan, Kun Liu, Wenying Wei, Qiang Cheng, Xinyue Liang, Yun Chen & Honglian Dai. (2022) Oriented nanofibrous P(MMD-co-LA)/Deferoxamine nerve scaffold facilitates peripheral nerve regeneration by regulating macrophage phenotype and revascularization. Biomaterials 280, pages 121288.
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Zachary J. Hawula, Rohan A. Davis, Daniel F. Wallace, Gautam Rishi & V. Nathan Subramaniam. (2021) In vitro identification and characterisation of iron chelating catechol-containing natural products and derivatives. BioMetals 34:4, pages 855-866.
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George Kontoghiorghes, Annita Kolnagou, Theodora Demetriou, Marina Neocleous & Christina Kontoghiorghe. (2021) New Era in the Treatment of Iron Deficiency Anaemia Using Trimaltol Iron and Other Lipophilic Iron Chelator Complexes: Historical Perspectives of Discovery and Future Applications. International Journal of Molecular Sciences 22:11, pages 5546.
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Yangmin Qiu, Yue Cao, Wangjia Cao, Yifei Jia & Na Lu. (2020) The Application of Ferroptosis in Diseases. Pharmacological Research 159, pages 104919.
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Viktor A. Timoshnikov, Tatyana V. Kobzeva, Nikolay E. Polyakov & George J. Kontoghiorghes. (2020) Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone. International Journal of Molecular Sciences 21:11, pages 3967.
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Kris V. Kowdley & Priya Handa. 2017. Schiff's Diseases of the Liver. Schiff's Diseases of the Liver 820 842 .
Pavel Zhabyeyev & Gavin Y. Oudit. (2017) Hemochromatosis Protein (HFE) Knockout Mice As a Novel Model of Hemochromatosis: Implications for Study and Management of Iron-Overload Cardiomyopathy. Canadian Journal of Cardiology 33:7, pages 835-837.
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Manle Qiu, Chongyang Wang, Daoyun Chen, Chaoyong Shen, Huakun Zhao & Yaohua He. (2016) Angiogenic and Osteogenic Coupling Effects of Deferoxamine-Loaded Poly(lactide-co-glycolide)-Poly(ethylene glycol)-Poly(lactide-co-glycolide) Nanoparticles. Applied Sciences 6:10, pages 290.
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Peng Jia, Hao Chen, Hui Kang, Jin Qi, Peng Zhao, Min Jiang, Lei Guo, Qi Zhou, Nian Dong Qian, Han Bing Zhou, You Jia Xu, Yongqian Fan & Lian Fu Deng. (2016) Deferoxamine released from poly(lactic-co-glycolic acid) promotes healing of osteoporotic bone defect via enhanced angiogenesis and osteogenesis. Journal of Biomedical Materials Research Part A 104:10, pages 2515-2527.
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Christina N Kontoghiorghe & George J Kontoghiorghes. (2016) New developments and controversies in iron metabolism and iron chelation therapy. World Journal of Methodology 6:1, pages 1.
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Eva Tvrda, Rohan Peer, Suresh C. Sikka & Ashok Agarwal. (2014) Iron and copper in male reproduction: a double-edged sword. Journal of Assisted Reproduction and Genetics 32:1, pages 3-16.
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Annita Kolnagou. (2014) Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases. World Journal of Methodology 4:4, pages 197.
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Christina N Kontoghiorghe. (2014) World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients. World Journal of Methodology 4:3, pages 163.
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Susu M. Zughaier, Brandon B. Stauffer & Nael A. McCarty. (2014) Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages. Journal of Immunology Research 2014, pages 1-16.
Crossref
Ali T. Taher, Khaled M. Musallam, Mehran Karimi & Maria D. Cappellini. (2012) Contemporary approaches to treatment of beta-thalassemia intermedia. Blood Reviews 26, pages S24-S27.
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J. P. Donnelly & M. Lahav. (2011) Deferasirox as adjunctive therapy for mucormycosis. Journal of Antimicrobial Chemotherapy 67:3, pages 519-520.
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Jy D. Chartres, Michael Busby, Mark J. Riley, Jason J. Davis & Paul V. Bernhardt. (2011) A Turn-on Fluorescent Iron Complex and Its Cellular Uptake. Inorganic Chemistry 50:18, pages 9178-9183.
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