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Hemoglobin
international journal for hemoglobin research
Volume 36, 2012 - Issue 6
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Original Article

A Single-Tube Multiplex Gap-Polymerase Chain Reaction for the Detection of Eight β-Globin Gene Cluster Deletions Common in Southeast Asia

Jaruwan TritipsombutBiomedical Science Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand;Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
,
Marion PhylipsenHemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
,
Vip ViprakasitDepartment of Pediatrics and Siriraj-Thalassemia Center, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
,
Nipon ChalaowMSc Immunology Programme, Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
,
Kanokwan SanchaisuriyaCentre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
,
Piero C. GiordanoHemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The NetherlandsCorrespondence[email protected]
,
Supan FucharoenCentre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
&
Cornelis L. HarteveldHemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
 show all
Pages 571-580 | Received 04 Jul 2012, Accepted 22 Aug 2012, Published online: 27 Nov 2012

Citations (23)

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Wanicha Tepakhan, Sataron Kanjanaopas & Korntip Srewaradachpisal. (2020) Association Between Genetic Polymorphisms and Hb F Levels in Heterozygous β-Thalassemia 3.5 kb Deletions. Hemoglobin 44:5, pages 338-343.
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Manit Nuinoon & Dararat Horpet. (2020) Simultaneous Characterization of Deletional and Nondeletional Globin Gene Mutations by Multiplex Real-Time-Polymerase Chain Reaction and High-Resolution Melting Curve Analysis . Hemoglobin 44:5, pages 311-318.
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Sheng He, Qian Qin, Li Lin, Yangjin Zuo, Qiuli Chen, Honghwei Wei, Chenguang Zheng, Biyan Chen & Xiaoxia Qiu. (2018) First Identification of the 3.5 kb Deletion (NC_000011.10: g.5224302-5227791del3490bp) on the β-Globin Gene Cluster in a Chinese Family. Hemoglobin 42:4, pages 272-275.
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Joanne Traeger-Synodinos & Cornelis L. Harteveld. (2017) Preconception carrier screening and prenatal diagnosis in thalassemia and hemoglobinopathies: challenges and future perspectives. Expert Review of Molecular Diagnostics 17:3, pages 281-291.
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Rakesh Kumar, Chandan Sagar, Dharmesh Sharma & Purnima Kishor. (2015) β-Globin Genes: Mutation Hot-Spots in the Global Thalassemia Belt. Hemoglobin 39:1, pages 1-8.
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Articles from other publishers (18)

Kritsada Singha, Anupong Pansuwan, Mattanee Chewasateanchai, Goonnapa Fucharoen & Supan Fucharoen. (2023) Molecular basis of non-deletional HPFH in Thailand and identification of two novel mutations at the binding sites of CCAAT and GATA-1 transcription factors. Scientific Reports 13:1.
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Archana M. Agarwal & Anton V. Rets. (2023) Molecular diagnosis of hereditary hemolytic anemias: Recent updates. International Journal of Laboratory Hematology 45:S2, pages 79-86.
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Jianlong Zhuang, Chunnuan Chen, Wanyu Fu, Yuanbai Wang, Qianmei Zhuang, Yulin Lu, Tiantian Xie, Ruofan Xu, Shuhong Zeng, Yuying Jiang, Yingjun Xie & Gaoxiong Wang. (2023) Third-Generation Sequencing as a New Comprehensive Technology for Identifying Rare α- and β-Globin Gene Variants in Thalassemia Alleles in the Chinese Population. Archives of Pathology & Laboratory Medicine 147:2, pages 208-214.
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Syahzuwan Hassan, Rosnah Bahar, Muhammad Farid Johan, Ezzeddin Kamil Mohamed Hashim, Wan Zaidah Abdullah, Ezalia Esa, Faidatul Syazlin Abdul Hamid & Zefarina Zulkafli. (2023) Next-Generation Sequencing (NGS) and Third-Generation Sequencing (TGS) for the Diagnosis of Thalassemia. Diagnostics 13:3, pages 373.
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Norafiza Mohd Yasin, Faidatul Syazlin Abdul Hamid, Syahzuwan Hassan, Aziee Sudin, Haiyuni Yassim, Ermi Neiza Mohd Sahid, Yuslina Mat Yusoff, Ezalia Esa & Mohamed Saleem. (2022) Molecular and hematological studies in a cohort of beta zero South East Asia deletion (β°-thal SEA) from Malaysian perspective. Frontiers in Pediatrics 10.
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Cornelis L. Harteveld, Ahlem Achour, Sandra J. G. Arkesteijn, Jeanet ter Huurne, Maaike Verschuren, Sharda Bhagwandien‐Bisoen, Rianne Schaap, Linda Vijfhuizen, Hakima el Idrissi & Tamara T. Koopmann. (2022) The hemoglobinopathies, molecular disease mechanisms and diagnostics. International Journal of Laboratory Hematology 44:S1, pages 28-36.
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Aisyah Aziz, Mohd Farid Baharin, Muhammad Yusri Fauzi, Faidatul Syazlin Abdul Hamid, Thiyagar Nadarajaw, Rahimah Ahmad & Hafizah Hashim. (2022) Rare cause of transfusion‐dependent hemolytic anemia: A case report of HbE/Hb Nottingham and literature review. Pediatric Blood & Cancer 69:9.
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YousefSaeed Mohammad Abu Za'ror, SitiNor Assyuhada Mat Ghani, NurSalwani Bakar, Zefarina Zulkafli & Maryam Azlan. (2022) Detection of BCL11A, HMIP, and XmnI polymorphisms among anemic pregnant women in hospital Universiti Sains Malaysia. Journal of Applied Hematology 13:4, pages 183.
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Phongsathorn Wichian, Supawadee Yamsri, Kanokwan Sanchaisuriya & Supan Fucharoen. (2021) Direct Amplification of Whole Blood and Amniotic Fluid Specimens for Prenatal and Postnatal Diagnosis of Hb E-β 0-Thalassemia Diseases. Laboratory Medicine 52:5, pages 460-468.
Crossref
Wanicha Tepakhan, Korntip Srewaradachpisal, Sataron Kanjanaopas & Wittaya Jomoui. (2021) Genetics background of β‐thalassemia (3.5 kb deletion) in Southern Thailand: Haplotype analysis using novel reverse dot blot hybridization. Annals of Human Genetics 85:3-4, pages 115-124.
Crossref
Siti Nor Assyuhada Mat Ghani, Rozieyati Mohamed Saleh, Wan Suriana Wan Ab Rahman, Mohd Nazri Hassan, Wan Zaidah Abdullah, Maryam Azlan & Zefarina Zulkafli. (2021) β-globin gene cluster mutations and large deletions among anaemic patients with elevated HbF level in a tertiary teaching hospital in Kelantan, Malaysia. Asia Pacific Journal of Molecular Biology and Biotechnology, pages 10-18.
Crossref
Siqi Hu, Wenli Zhan, Jicheng Wang, Jia Xie, Weiping Zhou, Xiaohan Yang, Yukun Zeng, Tingting Hu, Lei Duan, Keyi Chen, Li Du, Aihua Yin & Mingyong Luo. (2020) Establishment and application of a novel method based on single nucleotide polymorphism analysis for detecting β-globin gene cluster deletions. Scientific Reports 10:1.
Crossref
Sheng He, Yuan Wei, Li Lin, Qiuli Chen, Shang Yi, Yangjin Zuo, Hongwei Wei, Chenguang Zheng, Biyan Chen & XiaoXia Qiu. (2018) The prevalence and molecular characterization of (δβ) 0 -thalassemia and hereditary persistence of fetal hemoglobin in the Chinese Zhuang population . Journal of Clinical Laboratory Analysis 32:3, pages e22304.
Crossref
W.-J. Cai, J. Li, X.-M. Xie & D.-Z. Li. (2015) Screening for common β-globin gene cluster deletions in Chinese individuals with increased hemoglobin F. International Journal of Laboratory Hematology 37:6, pages 752-757.
Crossref
Kritsada Singha, Goonnapa Fucharoen, Abdulloh Hama & Supan Fucharoen. (2015) A novel Aγδβ0-thalassemia caused by DNA deletion–inversion–insertion of the β-globin gene cluster and five olfactory receptor genes: Genetic interactions, hematological phenotypes and molecular characterization. Clinical Biochemistry 48:10-11, pages 703-708.
Crossref
C. L. Harteveld. (2014) State of the art and new developments in molecular diagnostics for hemoglobinopathies in multiethnic societies. International Journal of Laboratory Hematology 36:1, pages 1-12.
Crossref
Jan Traeger-SynodinosCornelis L Harteveld. (2014) Advances in technologies for screening and diagnosis of hemoglobinopathies. Biomarkers in Medicine 8:1, pages 119-131.
Crossref
Nattaphol Prakobkaew, Supan Fucharoen, Goonnapa Fuchareon & Nirut Siriratmanawong. (2014) Phenotypic expression of Hb F in common high Hb F determinants in Thailand: roles of α-thalassemia, 5′ δ-globin BCL11A binding region and 3′ β-globin enhancer . European Journal of Haematology 92:1, pages 73-79.
Crossref

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