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Hemoglobin
international journal for hemoglobin research
Volume 37, 2013 - Issue 4
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Original Article

Leg Ulcers in Sickle Cell Disease: Current Patterns and Practices

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Pages 325-332 | Received 18 Oct 2012, Accepted 16 Jan 2013, Published online: 19 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Dominique Bulgin, Monika Asnani, Allison Vorderstrasse, Charmaine Royal, Wei Pan & Paula Tanabe. (2023) Stigma and quality of life in adults with sickle cell disease in Jamaica and the United States. Psychology, Health & Medicine 28:5, pages 1133-1147.
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Agata Janowska, Valentina Dini, Teresa Oranges, Michela Iannone, Barbara Loggini & Marco Romanelli. (2019) Atypical Ulcers: Diagnosis and Management. Clinical Interventions in Aging 14, pages 2137-2143.
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Patricia Adams-Graves & Lanetta Bronte-Jordan. (2016) Recent treatment guidelines for managing adult patients with sickle cell disease: challenges in access to care, social issues, and adherence. Expert Review of Hematology 9:6, pages 541-552.
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Carlton Dampier. (2015) Orphan drugs for sickle vaso-occlusion: dawn of a new era of targeted treatment. Orphan Drugs: Research and Reviews 5, pages 99-112.
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Articles from other publishers (45)

Bruno Deltreggia BenitesHeloise CiolSara Teresinha Olalla SaadRogerio Oliva Suguitani. (2023) Acupuncture as a Complementary Treatment for Leg Ulcers in Sickle-Cell Disease. Medical Acupuncture.
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Awni Alshurafa, Mohammed Alkhatib, Mohammad Abu-Tineh & Mohamed A. Yassin. (2023) Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report. Frontiers in Medicine 10.
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. (2023) Scientific and Clinical Abstracts From WOCNext® 2023. Journal of Wound, Ostomy & Continence Nursing 50:3, pages S1-S78.
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Valquíria Reis de Souza, Shannon Kelly, Ester Cerdeira Sabino, Franciane Mendes de Oliveira, Tassila Silva, Carolina Miranda Teixeira, Claudia Máximo, Paula Loureiro, Anna Barbara de Freitas Carneiro-Proietti, Isabel Gomes, Brian Custer & Cesar de Almeida-Neto. (2023) Factors Associated with Leg Ulcers in Adults with Sickle Cell Disease in Brazil. Advances in Skin & Wound Care 36:2, pages 98-105.
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Clark Brown, Modupe Idowu, Richard Drachtman, Anne Beaubrun, Irene Agodoa, Andy Nguyen, Kelly Lipman, Olga Moshkovich, Ryan Murphy, M. Alex Bellenger & Wally Smith. (2023) Patient-Reported Experiences in Voxelotor-Treated Children and Adults with Sickle Cell Disease: A Semistructured Interview Study. BioMed Research International 2023, pages 1-12.
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Agata Janowska, Marco Romanelli, Teresa Oranges, Giulia Davini, Michela Iannone & Valentina Dini. (2020) Prognostic Indicators of Wound Healing in Atypical Wounds: A Case Series. The International Journal of Lower Extremity Wounds 21:4, pages 529-534.
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Seda S. Tolu & Layla Van Doren. (2022) Acute and chronic pain management in patients with sickle cell disease in the modern era: a comprehensive review. Transfusion and Apheresis Science 61:5, pages 103533.
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Josimare Aparecida Otoni Spira, Eline Lima Borges, Antônio Carlos Martins Guedes, Paula Gabriela Ribeiro Andrade & Vera Lúcia de Araújo Nogueira Lima. (2022) Prevalence of people with sickle cell disease and leg ulcers in Brazil: Socioeconomic and clinical overview. PLOS ONE 17:9, pages e0274254.
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Seda S. Tolu, Andrew Crouch, Jaeun Choi, Qi Gao, Moramaya Reyes-Gil, Ugochi Olivia Ogu, Giacomo Vinces & Caterina P. Minniti. (2022) Hydroxyurea and fetal hemoglobin effect on leg ulcers in patients with sickle cell disease. Annals of Hematology 101:3, pages 541-548.
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Fredericka Sey & Ivy Ekem. 2022. Clinical Cases in Tropical Medicine. Clinical Cases in Tropical Medicine 170 172 .
Hanlin Jiang, Hui Xi, Mario Juhas & Yang Zhang. (2021) Biosensors for Point Mutation Detection. Frontiers in Bioengineering and Biotechnology 9.
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Julia Byeon, Katherine D. Blizinsky, Anitra Persaud, Keisha Findley, Jung‐Jin Lee, Ashley J. Buscetta, Shuo You, Kyle Bittinger, Caterina P. Minniti, Vence L. Bonham & Elizabeth A. Grice. (2021) Insights into the skin microbiome of sickle cell disease leg ulcers. Wound Repair and Regeneration 29:5, pages 801-809.
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Tarun Sahu, Henu Kumar Verma, Satyaki Ganguly, Meenakshi Sinha & Ramanjan Sinha. (2021) Common, But Neglected: A Comprehensive Review of Leg Ulcers in Sickle Cell Disease. Advances in Skin & Wound Care 34:8, pages 423-431.
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Caterina P. Minniti, Jennifer Knight‐Madden, Margaret Tonda, Sarah Gray, Joshua Lehrer‐Graiwer & Bart J. Biemond. (2021) The impact of voxelotor treatment on leg ulcers in patients with sickle cell disease. American Journal of Hematology 96:4.
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Vincent Maida, Runjie Bill Shi, Francesco Gabriele Tatangelo Fazzari & Lydia‐Marie Zomparelli. (2020) A new treatment paradigm for sickle cell disease leg ulcers: Topical cannabis‐based medicines. Experimental Dermatology 30:2, pages 291-293.
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Arturo J Martí-Carvajal, Jennifer M Knight-Madden & Maria José Martinez-Zapata. (2021) Interventions for treating leg ulcers in people with sickle cell disease. Cochrane Database of Systematic Reviews 2021:1.
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AyodeleOlukayode Iyun & OmobolajiIbukun Iyun. (2021) Pattern of presentation in a community outpatient wound clinic. Journal of West African College of Surgeons 11:3, pages 18.
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Charles Antwi-Boasiako, Biree Andemariam, Raffaella Colombatti, Eugenia Vicky Asare, Crawford Strunk, Connie M. Piccone, Deepa Manwani, Donna Boruchov, Fatimah Farooq, Rebekah Urbonya, Samuel Wilson, Gifty Dankwah Boatemaa, Silverio Perrotta, Laura Sainati, Angela Rivers, Sudha Rao, William Zempsky, Ivy Ekem, Fredericka Sey, Catherine Segbefia, Baba Inusa, Immacolata Tartaglione & Andrew D. Campbell. (2020) A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis. Annals of Hematology 99:9, pages 2073-2079.
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Patricia A. Shi & Karina Yazdanbakhsh. (2020) Transfusion in Sickle cell disease: best practice and understanding of its utility. ISBT Science Series 15:3, pages 347-351.
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Amanda M. BrandowC. Patrick Carroll, Susan CrearyRonisha Edwards-ElliottJeffrey GlassbergRobert W. HurleyAbdullah KutlarMohamed SeisaJennifer StinsonJohn J. Strouse, Fouza YusufWilliam Zempsky & Eddy Lang. (2020) American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain. Blood Advances 4:12, pages 2656-2701.
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Asfandyar Mufti, Khalad Maliyar, Maleeha Syed, Christian Pagnoux & Afsaneh Alavi. (2020) Approaches to Microthrombotic Wounds: A Review of Pathogenesis and Clinical Features. Advances in Skin & Wound Care 33:2, pages 68-75.
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MarcellinusUchechukwu Nwagu & GabriellaIfeoma Omokhua. (2020) Treatment of recalcitrant chronic leg ulcer in a known sickle cell anaemia patient using honey and fresh hbaa red cell concentrate in a Nigerian secondary healthcare facility. Annals of African Medicine 19:4, pages 278.
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Gabriela Queila de Carvalho-Siqueira, Galina Ananina, Bruno Batista de Souza, Murilo Guimarães Borges, Mirta Tomie Ito, Sueli Matilde da Silva-Costa, Igor de Farias Domingos, Diego Arruda Falcão, Iscia Lopes-Cendes, Marcos André Cavalcanti Bezerra, Aderson da Silva Araújo, Antônio Roberto Lucena-Araújo, Marilda de Souza Gonçalves, Sara Teresinha Olalla Saad, Fernando Ferreira Costa & Mônica Barbosa de Melo. (2019) Whole-exome sequencing indicates FLG 2 variant associated with leg ulcers in Brazilian sickle cell anemia patients . Experimental Biology and Medicine 244:11, pages 932-939.
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Esaie Soya, Caroline Makowski & Sophie Blaise. (2019) Leg ulcer induced by hydroxycarbamide in sickle cell disease: What is the therapeutic impact?. International Wound Journal 16:4, pages 897-902.
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Brooke Allemang, Kate Allan, Colleen Johnson, Melina Cheong, Patrina Cheung, Isaac Odame, Richard Ward, Suzan Williams, Geetha Mukerji & Kevin H.M. Kuo. (2019) Impact of a transition program with navigator on loss to follow‐up, medication adherence, and appointment attendance in hemoglobinopathies. Pediatric Blood & Cancer 66:8.
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Bhaskar V.K.S. Lakkakula, Radharani Sahoo, Henu Verma & Saikrishna Lakkakula. (2018) Pain Management Issues as Part of the Comprehensive Care of Patients with Sickle Cell Disease. Pain Management Nursing 19:6, pages 558-572.
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Melanie RodriguesClark A. BonhamCaterina P. MinnitiKalpna GuptaMichael T. LongakerGeoffrey C. Gurtner. (2018) Iron Chelation with Transdermal Deferoxamine Accelerates Healing of Murine Sickle Cell Ulcers. Advances in Wound Care 7:10, pages 323-332.
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Federica Dassoni. 2018. Pigmented Ethnic Skin and Imported Dermatoses. Pigmented Ethnic Skin and Imported Dermatoses 189 202 .
Anne M. Andong, Eveline D. T. Ngouadjeu, Cavin E. Bekolo, Vincent S. Verla, Daniel Nebongo, Yannick Mboue-Djieka & Simeon-Pierre Choukem. (2017) Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study. BMC Hematology 17:1.
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P. Senet, C. Blas-Chatelain, P. Levy, E.M. Manea, M. Peschanski, T. Mirault, K. Stankovic-Stojanovic, C. Debure, K. Debbache, R. Girot, J.-M. Bureau, C. Bachmeyer, C. Baldeschi, F. Galacteros, F. Lionnet & J. Gellen-Dautremer. (2017) Factors predictive of leg-ulcer healing in sickle cell disease: a multicentre, prospective cohort study. British Journal of Dermatology 177:1, pages 206-211.
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Bernard A. Davis, Shubha Allard, Amrana Qureshi, John B. Porter, Shivan Pancham, Nay Win, Gavin Cho & Kate Ryan. (2016) Guidelines on red cell transfusion in sickle cell disease Part II : indications for transfusion . British Journal of Haematology 176:2, pages 192-209.
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Igor A Altman, Raymond E Kleinfelder, John G Quigley, William J Ennis & Caterina P Minniti. (2016) A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease. International Wound Journal 13:6, pages 1315-1324.
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José Válber L. Meneses, Vitor Fortuna, Eliane Silva de Souza, Gildasio Cerqueira Daltro, Roberto Meyer, Caterina P. Minniti & Radovan Borojevic. (2016) Autologous stem cell-based therapy for sickle cell leg ulcer: a pilot study. British Journal of Haematology 175:5, pages 949-955.
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Simeon Pollack. (2016) RX of sickle cell leg ulcers. International Wound Journal 13:5, pages 1091-1091.
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Shawn M Bediako, Sophie Lanzkron, Marie Diener-West, Gladys Onojobi, Mary C Beach & Carlton HaywoodJrJr. (2014) The Measure of Sickle Cell Stigma: Initial findings from the Improving Patient Outcomes through Respect and Trust study. Journal of Health Psychology 21:5, pages 808-820.
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Van Tuan Nguyen, Dany Nassar, Fréderic Batteux, Karine Raymond, Pierre-Louis Tharaux & Sélim Aractingi. (2016) Delayed Healing of Sickle Cell Ulcers Is due to Impaired Angiogenesis and CXCL12 Secretion in Skin Wounds. Journal of Investigative Dermatology 136:2, pages 497-506.
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Caterina P. Minniti & Gregory J. Kato. (2015) Critical Reviews: How we treat sickle cell patients with leg ulcers. American Journal of Hematology 91:1, pages 22-30.
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Afsaneh Alavi & Robert S. Kirsner. (2015) Hemoglobinopathies and Leg Ulcers. The International Journal of Lower Extremity Wounds 14:3, pages 213-216.
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Mihir Gupta, Tasneem Poonawala, Mariya Farooqui, Marna E Ericson & Kalpna Gupta. (2015) Topical fentanyl stimulates healing of ischemic wounds in diabetic rats 局部芬太尼麻醉可以促进糖尿病大鼠缺血性伤口的愈合. Journal of Diabetes 7:4, pages 573-583.
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Ikechukwu Igwegbe, Gladys Onojobi, Margaret O. Fadojutimi-Akinsiku, Alan M. Hirsh, Nanjin J. Park, Min Yao & Vickie R. Driver. (2015) Case Studies Evaluating Transdermal Continuous Oxygen for the Treatment of Chronic Sickle Cell Ulcers. Advances in Skin & Wound Care 28:5, pages 206-210.
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Fredericka Sey & Ivy Ekem. 2015. Clinical Cases in Tropical Medicine. Clinical Cases in Tropical Medicine 241 243 .
Caterina P Minniti, Alexander M Gorbach, Dihua Xu, Yuen Yi Hon, Kara-Marie Delaney, Miles Seidel, Nitin Malik, Marlene Peters-Lawrence, Carly Cantilena, James S Nichols, Laurel Mendelsohn, Anna Conrey, George Grimes & Gregory J Kato. (2014) Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial. The Lancet Haematology 1:3, pages e95-e103.
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Flávia Cristine Mascia Lopes, Regiane Ferreira, Dulcinéia Martins Albuquerque, Angélica A. Antoniellis Silveira, Raquel Costa, Raquel Soares, Fernando Ferreira Costa & Nicola Conran. (2014) In vitro and in vivo anti-angiogenic effects of hydroxyurea. Microvascular Research 94, pages 106-113.
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Caterina P. Minniti, Kara-Marie H. Delaney, Alexander M. Gorbach, Dihua Xu, Chyi-Chia Richard Lee, Nitin Malik, Antony Koroulakis, Matthew Antalek, Jordan Maivelett, Marlene Peters-Lawrence, Enrico M. Novelli, Sophie M. Lanzkron, Karen C. Axelrod & Gregory J. Kato. (2014) Vasculopathy, inflammation, and blood flow in leg ulcers of patients with sickle cell anemia. American Journal of Hematology 89:1, pages 1-6.
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Philippe Connes, Yann Lamarre, Marie-Dominique Hardy-Dessources, Nathalie Lemonne, Xavier Waltz, Danièle Mougenel, Martin Mukisi-Mukaza, Marie-Laure Lalanne-Mistrih, Vanessa Tarer, Benoit Tressières, Maryse Etienne-Julan & Marc Romana. (2013) Decreased Hematocrit-To-Viscosity Ratio and Increased Lactate Dehydrogenase Level in Patients with Sickle Cell Anemia and Recurrent Leg Ulcers. PLoS ONE 8:11, pages e79680.
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